Status of Surgical Management of Borderline Ovarian Tumors in France: are Recommendations Being Followed? Multicentric French Study by the FRANCOGYN Group

Lecointre, Lise; Bund, Virginie; Sangnier, Eva; Ouldamer, Lobna; Bendifallah, Sofiane; Koskas, Martin; Bolze, Pierre‐Adrien; Collinet, Pierre; Canlorbe, Geoffroy; Touboul, Cyril; Huchon, Cyrille; Coutant, Charles; Faller, Émilie; Boisramé, Thomas; Gantzer, Justine; Demarchi, Martin; Lavoué, Vincent; Akladios, Chérif

doi:10.1245/s10434-021-09852-9

Cited by 7 publications

(3 citation statements)

References 26 publications

(45 reference statements)

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“…Interestingly, the benefit of restaging surgery after the incomplete staging is still debatable. In their study, Lecointre et al highlighted the main indications of restaging surgery as cystectomy in mucinous tumor or serous tumor with a micropapillary component, incomplete peritoneal exploration, a defective surgical technique that led to seeding, and peritoneal lesions after the primary surgery in the case of residual gross (38).…”

Section: Discussionmentioning

confidence: 99%

Management of borderline ovarian tumors: A tertiary referral center experience in Egypt

et al. 2022

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BackgroundIn this retrospective study, we discuss our experience as a large tertiary referral center in Egypt in the management and follow-up of borderline tumorsPatients and methodsThis is a retrospective cohort study where all patients diagnosed with a borderline ovarian tumor at Oncology Center Mansoura University from November 2014 to June 2020 were included. Demographics, preoperative, operative, postoperative, pathologic, and oncologic follow-up data were retrieved from a prospectively maintained electronic database. The included patients were followed until April 2022.ResultsWe included 27 patients with borderline ovarian tumors. The mean age of the study patients was 47.67 ± 16.39 years. The median CA 125 was 33 (6–304 U/ml). Frozen section examination was utilized in 13 patients (48.14%), where a diagnosis of borderline ovarian tumors was revealed in 8 patients. Recurrence was reported in one patient with serous type after approximately 26 months. The most common pathological type in our cohort was the mucinous borderline type reported in 14 patients (51.9%), followed by the serous type reported in 11 patients (40.7%), and the seromucinous type in 1 patient only. Patients with mucinous borderline type were significantly younger (40.083 ± 18.47 vs. 53.73 ± 11.91 years, p = 0.028). Interestingly, Cancer Antigen 125 levels were significantly higher in mucinous than serous and seromucinous types [67(16–304) vs. 20(6–294.6) U/ml, p = 0.027]. On the other hand, the radiological tumor size of serous and seromucinous types was larger than that of the mucinous type [23(19–31) cm vs. 8(5–20) cm, p = 0.001]. Over a median follow-up period of 58.66 (54.16–63.16) months, only one postoperative mortality was reported, while only one recurrence was reported.ConclusionBorderline ovarian tumors still represent a dilemma either in diagnosis or management. A frozen section examination could help to reach a preliminary diagnosis. Total abdominal hysterectomy and bilateral salpingo-oophorectomy are the cornerstone of surgical management; however, fertility-sparing surgery could be a valid option for women desiring fertility.

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Section: Discussionmentioning

confidence: 99%

Management of borderline ovarian tumors: A tertiary referral center experience in Egypt

et al. 2022

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“…Elevated levels of certain miRNAs, specifically three, have been identified to influence the expression and function of progesterone receptors, contributing to progesterone resistance, a critical factor in the pathophysiology of endometriosis [45][46][47][48]. The miRNAs implicated in this mechanism include miR-29c-3p, miR-126-3p, and miR-143-3p, with a particular focus on miR-143-3p due to its notable presence in the circulation and ectopic lesions of endometriosis patients [49][50][51].…”

Section: Increased Levels Of Mirnas Favor Survival Feature and Lead T...mentioning

confidence: 99%

Endometriosis: Molecular Pathophysiology and Recent Treatment Strategies—Comprehensive Literature Review

Sadłocha,

Toczek,

Major

et al. 2024

Pharmaceuticals

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Endometriosis is an enigmatic disease, with no specific cause or trigger yet discovered. Major factors that may contribute to endometriosis in the pelvic region include environmental, epigenetic, and inflammatory factors. Most experts believe that the primary mechanism behind the formation of endometrial lesions is associated with Sampson’s theory of “retrograde menstruation”. This theory suggests that endometrial cells flow backward into the peritoneal cavity, leading to the development of endometrial lesions. Since this specific mechanism is also observed in healthy women, additional factors may be associated with the formation of endometrial lesions. Current treatment options primarily consist of medical or surgical therapies. To date, none of the available medical therapies have proven effective in curing the disorder, and symptoms tend to recur once medications are discontinued. Therefore, there is a need to explore and develop novel biomedical targets aimed at the cellular and molecular mechanisms responsible for endometriosis growth. This article discusses a recent molecular pathophysiology associated with the formation and progression of endometriosis. Furthermore, the article summarizes the most current medications and surgical strategies currently under investigation for the treatment of endometriosis.

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“…Random Forest (RF) was considered to design the saliva signature [34][35][36][37][54][55][56]. Random Forest (RF) classifier is an ensemble method that trains several Decision Tree (DT) in parallel with bootstrapping followed by aggregation, jointly referred to as bagging.…”

Section: Development and Validation Of The Diagnostic Modelmentioning

confidence: 99%

Salivary MicroRNA Signature for Diagnosis of Endometriosis

Bendifallah

Suisse²,

Puchar

et al. 2022

JCM

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Background: Endometriosis diagnosis constitutes a considerable economic burden for the healthcare system with diagnostic tools often inconclusive with insufficient accuracy. We sought to analyze the human miRNAome to define a saliva-based diagnostic miRNA signature for endometriosis. Methods: We performed a prospective ENDO-miRNA study involving 200 saliva samples obtained from 200 women with chronic pelvic pain suggestive of endometriosis collected between January and June 2021. The study consisted of two parts: (i) identification of a biomarker based on genome-wide miRNA expression profiling by small RNA sequencing using next-generation sequencing (NGS) and (ii) development of a saliva-based miRNA diagnostic signature according to expression and accuracy profiling using a Random Forest algorithm. Results: Among the 200 patients, 76.5% (n = 153) were diagnosed with endometriosis and 23.5% (n = 47) without (controls). Small RNA-seq of 200 saliva samples yielded ~4642 M raw sequencing reads (from ~13.7 M to ~39.3 M reads/sample). Quantification of the filtered reads and identification of known miRNAs yielded ~190 M sequences that were mapped to 2561 known miRNAs. Of the 2561 known miRNAs, the feature selection with Random Forest algorithm generated after internally cross validation a saliva signature of endometriosis composed of 109 miRNAs. The respective sensitivity, specificity, and AUC for the diagnostic miRNA signature were 96.7%, 100%, and 98.3%. Conclusions: The ENDO-miRNA study is the first prospective study to report a saliva-based diagnostic miRNA signature for endometriosis. This could contribute to improving early diagnosis by means of a non-invasive tool easily available in any healthcare system.

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Status of Surgical Management of Borderline Ovarian Tumors in France: are Recommendations Being Followed? Multicentric French Study by the FRANCOGYN Group

Cited by 7 publications

References 26 publications

Management of borderline ovarian tumors: A tertiary referral center experience in Egypt

Management of borderline ovarian tumors: A tertiary referral center experience in Egypt

Endometriosis: Molecular Pathophysiology and Recent Treatment Strategies—Comprehensive Literature Review

Salivary MicroRNA Signature for Diagnosis of Endometriosis

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