Status of some Trace Elements in Type-2 Diabetic Patients and its Relationship with Lipid Profile

Abstract

Investigation of the serum level of copper, zinc, magnesium and manganese in type-2 diabetes mellitus and their possible association with lipid profile was carried out. The comparative study included 100 type-2 diabetic patients in Gr-II and 100 non-diabetic as control in (Gr-I). Results indicated that there is a significant lower level (p < .001) of serum Zn, Cu, Mg and Mn in diabetic patients compared with the control group, showing p value < .001. In type-2 DM patients (Gr-II) there were significant correlations between serum Zn and TAG (r = 0.209) and between Zn and HDL-C level (r = .199) showing p value <.05. Non significant relationships were found in between Zn and lipid profile (TAG, Cholesterol, HDL-C and LDL-C) of control (Gr-I) group. Significant correlation was found between serum magnesium and TAG of control (Gr-I) where p < .01 and non significant correlations were found in serum Mg and total cholesterol, HDL-C, LDL-C of both type-2 diabetic (Gr-II) and control (Gr-I). Significant correlations were also found in between serum of Cu and Mn and TAG of control (Gr-I) where p < .05 and non significant correlations were found in other component of lipid profile of both cases (Gr-II) and control (Gr-I).

Tip 2 Diabetes Mellitus Hastalarında Serum Çinko, Selenyum, Mangan, Demir, Bakır Element Düzeyleri ve Cu/Zn, Cu/Se, Cu/Mn, Fe/Zn, Fe/Se, Fe/Mn Oranlarının Değerlendirilmesi

“…12 Bu bilgileri dikkate alarak yaptığımız literatür araştırmasında glikoz metabolizması ve/veya oksidatif stresle ilişkili oldukları bildirilen bu elementler ile T2DM hastalığı arasındaki ilişkiyi araştıran çok sayıda çalışmanın bulunduğunu ancak bu araştırmalarda çelişkili bulguların var olduğu görülmüştür. 1,6,[13][14][15][16][17][18][19]…”