Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes

Chitra, Prasad; Chaki, Debolina; Boiroju, Naveen Kumar; Mokalla, Thirupathi Reddy; Gadde, Aruna K.; Agraharam, Satish Gooty; Reddy, G. Bhanuprakash

doi:10.1016/j.exer.2020.108230

Cited by 27 publications

(23 citation statements)

References 47 publications

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“…AGI might represent a better glycemic control marker than HbA1c in diabetic patients with kidney insufficiency. In a recent study, Chitra et al reported that plasma AGI was significantly ( P < 0.05) associated with diabetic cataracts ( 46 ). In a recent study, Farhan et al reported an association between AGEs/soluble RAGE ratio and urinary albumin/serum creatinine ratio in type II diabetic patients ( 47 ).…”

Section: Discussionmentioning

confidence: 98%

Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria

et al. 2021

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The prevalence of diabetes reaches epidemic proportions. Diabetes is the leading cause of end-stage kidney disease (ESKD) since 30–40% of diabetic patients develop diabetic nephropathy. Albuminuria and glomerular filtration rate used to assess kidney function are considered surrogate outcomes of chronic kidney disease. The search for a biomarker that predicts progression to diabetic kidney disease is intense. We analyzed the association of serum advanced glycation end-products (AGEs) index (AGI) with impaired kidney function in poorly controlled type II diabetic patients. We observed an association between AGI and impaired kidney function in microalbuminuria patients with hyperglycemia. A significant association between AGEs, particularly carboxymethyl lysine (CML), and impaired kidney function were observed. Administration of AGEs to mice showed heavy proteinuria and glomerular abnormalities. Reduced podocyte number in mice administered with AGEs could be attributed to the epithelial-mesenchymal transition of podocytes. Our study suggests CML could be independently related to the podocyte injury and the risk of DN progression to ESKD in patients with microalbuminuria. AGEs in general or CML could be considered a prognostic marker to assess diabetic kidney disease.

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Section: Discussionmentioning

confidence: 98%

Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria

et al. 2021

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“…The elder age cataract may be irreversible while the cataract developed in young diabetic patient can be reversible in nature [15]. The reduction of glucose molecules into sorbitol by help of aldose reductase enzyme is the central mechanism for development of cataract this pathway also known as polyol pathway [16]. In the polyol pathway there is degeneration of lens due to hyperosmotic effect due to intracellular accumulation of sorbitol at membrane [17].…”

Section: Discussionmentioning

confidence: 99%

“…This mechanism stronger in diabetic population because there is quick conversion of sorbitol in to fructose by help of sorbitol dehydrogenase enzyme so diabetic population more prone to development of cataract as compared to general population. Another explanation for cataract formation in diabetics occurring sooner owing to early degenerative alterations in lens protein is this process [14,16,17]. Glucose 6 Phosphate Dehydrogenase (G6PD) is the main regulatory enzyme for this function.…”

Section: Discussionmentioning

confidence: 99%

Role of Glucose 6 Phosphate Dehydrogenase (G6PD) in Diabetic Cataract

Bhatti

Memon

Laghari

et al. 2021

JPRI

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Introduction: Diabetes mellitus and its complications are spreading with increased rate in Asian population especially in Pakistan. Uncontrolled diabetes can lead to different micro vascular complications. Cataract is one of the complications of diabetes which may lead to lens degenerative changes and visual impairment. G6PD plays a vital role in preventive measurements from cataract development in normal population. Objectives: This Study was designed to estimate G6PD levels in diabetic without ocular manifestations & diabetic cataract population. Methodology: This cross sectional comparative study was done at the Department of Biochemistry LUMHS Jamshoro in collaboration with the Diabetic clinic, Institute of Ophthalmology & Diagnostic Research Laboratory LUMHS Jamshoro. 100 diagnosed subjects of diabetes were selected by Non-Probability type of sample technique with consent of subjects and they were divided in to two groups Group A as control 50 diabetic subjects with out ocular manifestation while Group B as case study group contain 50 subjects of diabetes with cataract. The fasting blood glucose level was estimated by Hexokinase Method while G6PD level was measured by kit method on SD Biosensor while HbA1c(% ) was estimated by TTAB methodology. The data was statistically analyzed by SPSS 21. Results: The mean level of G6PD in Group A was 15.63±2.45 u/Hb while in group B it was 9.01±3.11 u/G HB. This result finally concluded that there was significantly (<0.05) decline of G6PD diabetic cataract as compared with diabetic without cataract. Conclusion: This study concluded that there was significant decline in G6PD level in diabetic cataract. It is also concluded that the estimation of G6PD level in diabetic population will be beneficial to take early preventive measurements against diabetic vascular complications.

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“…23,24 The complications of diabetes are mostly the consequence of advanced glycation end products 25 or oxidative processes. 26,27 Examples of these are the cataract found in the eyes of diabetics, which is predominantly the consequence of glycation of the normally highly transparent lens proteins 28 and the diabetic retinopathy and nephropathy, which are more the consequence of oxidative damage to the blood vessels in these organs. 29,30 Consequently, therapeutic strategies for this metabolic disorder include inhibition of glucose processing and absorption in the intestines, 31 stimulation of hepatic and muscle uptake of glucose by insulin, 32,33 supplementing insulin, 34 stimulating insulin release, 35 decreasing peripheral insulin resistance, 36 inhibition of glucose reabsorption in the kidneys, 37 and prevention of the glycation and oxidation of biologically active proteins.…”

Section: Introductionmentioning

confidence: 99%

“…The complications of diabetes are mostly the consequence of advanced glycation end products 25 or oxidative processes. 26 , 27 Examples of these are the cataract found in the eyes of diabetics, which is predominantly the consequence of glycation of the normally highly transparent lens proteins 28 and the diabetic retinopathy and nephropathy, which are more the consequence of oxidative damage to the blood vessels in these organs. 29 , 30 …”

Section: Introductionmentioning

confidence: 99%

A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect

Ranđelović

Bipat

2021

Clin Med Insights Endocrinol Diabetes

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Background and aims: Worldwide, type 2 diabetes mellitus accounts for a considerable burden of disease, with an estimated global cost of >800 billion USD annually. For this reason, the search for more effective and efficient therapeutic anti-diabetic agents is continuing. Coumarins are naturally derived and synthetic molecules with a wide variety of biological actions. The most common application of these molecules in medicine is for their thrombostatic activity. This study aims to give an overview of the current knowledge about the applicability of these chemical products in the therapeutic strategy against diabetes and its complications. Methods: For this purpose, we searched internet databases for publications and abstracts in English that investigated the effects of coumarins or coumarin-like agents with potential anti-diabetic activity. Results: The result is that a variety of these agents have proven in in vitro, in silico, and simple animal models to possess properties that may reduce the glucose absorption rate in the intestines, increase the level of insulin, increase the cellular uptake of glucose or reduce the gluconeogenesis. In addition, some of these agents also reduced the level of glycation of peptides in diabetic animal models and showed antioxidant properties. Conclusion: In conclusion, we can summarize that coumarins and their related derivatives may be potential antidiabetic agents. Useful formulations with appropriate pharmacokinetic and pharmacodynamic properties must be developed and tested for their efficacy and toxicity in comprehensive animal models before they can enter clinical trials.

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Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes

Cited by 27 publications

References 47 publications

Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria

Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria

Role of Glucose 6 Phosphate Dehydrogenase (G6PD) in Diabetic Cataract

A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect

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