Status of malondialdehyde, catalase and superoxide dismutase levels/activities in schoolchildren with iron deficiency and iron-deficiency anemia of Kashere and its environs in Gombe State, Nigeria

Usman, Sani Sharif; Dahiru, M.; Abdullahi, Bashir; Abdullahi, Shariff Bilal; Maigari, Usman Muhammad; Uba, Abdullahi Ibrahim

doi:10.1016/j.heliyon.2019.e02214

Cited by 15 publications

(7 citation statements)

References 38 publications

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“…This can be an adaptive mechanism during the oxidative stress context of anemia, whereby sustained increased levels of erythrocyte H 2 O 2 induce GPx and other antioxidant enzymes 24 , 43 , resulting in an increased redox status. However, considerable variations exist in human studies with regard to ID and redox status 44 , which can be attributed to the study differences in sample size, age of subjects, distribution of males and females in the sample, and severity of ID. For example, Altun et al 24 found no increase in GPx activity in groups of infants with IDA when compared with aged-matched controls.…”

Section: Discussionmentioning

confidence: 99%

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Alkazemi

Rahman

Habra

2021

Sci Rep

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The reduced (GSH)-to-oxidized (GSSG) glutathione ratio represents a dynamic balance between oxidants and antioxidants. However, redox status in adolescents with obesity and anemia has not been investigated. This study investigated the association of erythrocyte GSH redox status (GSH, GSH:GSSG ratio, and glutathione peroxidase [GPx] activity) with anemia and adiposity in adolescents. This case–control study nested in a cross-sectional study enrolled 524 adolescents (268 boys; 256 girls). The prevalence of anemia in overweight and obesity (OWOB) was 5.2% in boys and 11.7% in girls. The GSH:GSSG ratio and GPx activity were significantly higher in girls than in boys (p < 0.001), in anemic than in non-anemic subjects (p < 0.001), and in OWOB than in normal-weight subjects (p < 0.001). Similarly, significantly higher GSH: GSSG level (p < 0.001) and GPx activity (p < 0.001) were found in subjects with 90th percentile waist circumference than in those with < 90th percentile. GPx and GSH:GSSG were positively associated with anemia after adjusting for age, sex, and body mass index (adjusted odds ratio, adjOR [95% confidence interval, CI] 2.18 [1.44–3.29]) or tertiles (adjOR [95% CI], T3 = 2.49 [1.03–6.01]). A similar association was noted for GSH and GPx. A compensatory increased redox defense mechanism exists in anemia and obesity among adolescents without metabolic disturbances.

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Section: Discussionmentioning

confidence: 99%

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Alkazemi

Rahman

Habra

2021

Sci Rep

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“…Dalam proses belajar, pengetahuan seseorang diperoleh dengan melibatkan semua panca indera (Hussain et al, 2018) Semakin banyak seseorang memperoleh informasi akan semakin kompleks pengetahuan yang didapatkan (Julaecha, 2020). Dalam menunjang pengetahuan yang kompleks dalam proses belajar dibutuhkan beberapa penunjang seperti penggunaan media sebagai alat bantu yang disebut media komunikasi (Sharif Usman et al, 2019).…”

Section: Pembahasanunclassified

Penggunaan Booklet terhadap Pengetahuan Anemia pada Remaja Putri

Yulianingsih

Suherlin

Aswad

et al. 2021

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Anemia is still a reproductive health problem, especially in women whose hemoglobin levels are less than 12 g%. Education is one of the factors that influence the incidence of anemia and also greatly affects the ability to think in adolescents. The purpose of this study was to analyze health education through knowledge booklets about anemia in adolescents in Gorontalo City. This type of research uses the Pre-Experimental method with One-Group Pre-Test-Post Test Design, with a sample of 132 young women using a simple random sampling technique. The study started from February 1 to March 1, 2020. The analysis in this study used the Wilcoxon test. The results showed that there was a significant effect of health education through booklets on knowledge of anemia in adolescents with a sig value of 0.000 <0.05. The conclusion is that there is an effect of health education through booklets on knowledge about anemia in adolescent girls.

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“…The production of hemoglobin and other iron-containing proteins such as cytochrome, myoglobin, catalase and peroxidase is also affected in ID (3,4). In addition, studies have shown decreases in concentrations and activities of antioxidant enzymes such as glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) in patients with IDA, thus reducing the total antioxidant capacity (TAC) (5,6).…”

Section: Introductionmentioning

confidence: 99%

Dynamic Thiol-Disulfide Homeostasis in Children with Newly Diagnosed Iron Deficiency Anemia

Kurucu

Fettah

Yeşil

et al. 2023

Türkiye Çocuk Hast Derg

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Objective: Iron is an element, which is found in the structure of antioxidant enzymes and has an important role in the inactivation of reactive oxygen species. Disruption of oxidant-antioxidant balance may be playing a role in the pathogenesis of iron deficiency anemia (IDA). Dynamic thiol-disulfide homeostasis (DTDH) and serum ischemia-modified albumin (IMA) levels are important indicators of pro-oxidant/antioxidant status. In this study, we aimed to evaluate DTDH parameters and serum IMA levels in children with newly diagnosed IDA, who did not receive iron therapy. Material and Methods: Fifty patients diagnosed with IDA and 33 healthy age- and sex-matched control patients were included in the study. DTDH parameters and IMA levels of the patients and control groups were measured. The same parameters were also compared in patients with Hb<7 g/dl (profound IDA) (n:14/50, 28%) and Hb≥7 g/dl (mild-moderate IDA) (n: 36/50, 72%) in the IDA group. The relationship between DTDH parameters in these groups were investigated. Results: Native thiol, total thiol, native thiol/total thiol levels, constituting antioxidant capacity indicators, were found to be significantly lower in IDA patients; while oxidant disulfide, disulfide/native thiol, disulfide/total thiol, and IMA levels were found to be statistically higher compared to those in the control group (p<0.050). When DTDH parameters and IMA levels were examined; there was a positive correlation between antioxidant parameters and a negative correlation between oxidative parameters with hemoglobin and ferritin levels (p<0.050). Also, oxidative parameters were found to be much higher in profound IDA group than in the group with Hb>7 g/dl (p<0.050). Conclusion: In this study, increase in serum disulfide and IMA levels with the decrease in serum native thiol and total thiol levels indicated oxidative stress in IDA patients before treatment, compared to the control group. Evaluation of these indicators in children is important in predicting the toxicity due to IDA.

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Status of malondialdehyde, catalase and superoxide dismutase levels/activities in schoolchildren with iron deficiency and iron-deficiency anemia of Kashere and its environs in Gombe State, Nigeria

Cited by 15 publications

References 38 publications

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Penggunaan Booklet terhadap Pengetahuan Anemia pada Remaja Putri

Dynamic Thiol-Disulfide Homeostasis in Children with Newly Diagnosed Iron Deficiency Anemia

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