Status of low-energy accelerator-based BNCT worldwide and in Argentina

Cartelli, D.; Capoulat, M.E.; Baldo, M.; Sandin, J.C. Suarez; Igarzábal, M.; Grosso, M.F. del; Valda, A.A.; Canepa, N.; Gun, Marcelo; Minsky, D.M.; Conti, G.; Erhardt, J.; Somacal, H.; Bertolo, A.A.; Bergueiro, J.; Gaviola, P.A.; Kreiner, Andrés J.

doi:10.1016/j.apradiso.2020.109315

Cited by 20 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BNCT is attracting much more attentions in recent years since the accelerator-based cancer treatment has obtained regulatory approval in Japan. [4][5][6] In parallel, a lot of works for BNCT drugs with small compounds, macromolecules or nanomaterials have been reported, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] including poly(glycerol) (PG) functionalized detonation nanodiamonds (DNDs), namely DNDÀ PG, conjugated with 10 B-containing moiety we reported recently. [23] Nanodiamonds (NDs) including DNDs are biologically inert nanoparticles and subjected to various chemical modifications covalently through oxygen containing functional groups on the surface via robust processes.…”

Section: Introductionmentioning

confidence: 98%

Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting Moiety for Boron Neutron Capture Therapy

Nishikawa,

Yu,

Kang

et al. 2023

Chemistry A European J

View full text Add to dashboard Cite

Boron neutron capture therapy (BNCT), advanced cancer treatment utilizing nuclear fission of 10B atom in cancer cells, is attracting increasing attention. As 10B delivery agent, sodium borocaptate (10BSH), has been used in clinical studies along with L‐boronophenylalanine. Recently, 10BSH has been conjugated with lipids, polymers or nanoparticles to increase selectivity to and the retentivity in tumor. In this work, we designed the anticancer nanoformulations for BNCT consisting of poly(glycerol) functionalized detonation nanodiamonds (DND‐PG) as a hydrophilic nanocarrier, 10BSH as a dense boron‐10 source, and phenylboronic acid or RGD peptide as an active targeting moiety. For their conjugation, some hydroxy groups in PG were oxidized to carboxy groups (DND‐PG‐COOH) to conjugate the active targeting moiety through amide linkage. Some hydroxy groups in DND‐PG‐COOH were then transformed to azide to conjugate 10BSH through click chemistry. After qualitative and quantitative characterization, the nanodrugs were evaluated in vitro using B16 murine melanoma cells in terms of cell viability and BNCT efficacy. As a result, the nanodrugs with and without the targeting moiety exhibited good anticancer efficacies with slight differences upon thermal neutron irradiation. By TEM observation, 10BSH moiety was found to facilitate the cellular uptake more efficiently than the active targeting moieties.

show abstract

Section: Introductionmentioning

confidence: 98%

Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting Moiety for Boron Neutron Capture Therapy

Nishikawa,

Yu,

Kang

et al. 2023

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…Several accelerators were installed and actually used for clinical trials or are under development around the World (e.g. Refs2, 149, 150). These sources would expand the clinical BNCT services to more patients, and would conceivably help to make BNCT a standard treatment modality for various types of cancer (Ref 17…”

Section: Accelerator-based Bnct Studiesmentioning

confidence: 99%

Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

Hughes

2022

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam. BNCT clinical results to date show therapeutic efficacy, associated with an improvement in patient quality of life and prolonged survival. Translational research in adequate experimental models is necessary to optimise BNCT for different pathologies. This review recapitulates some examples of BNCT radiobiological studies for different pathologies and clinical scenarios, strategies to optimise boron targeting, enhance BNCT therapeutic effect and minimise radiotoxicity. It also describes the radiobiological mechanisms induced by BNCT, and the importance of the detection of biomarkers to monitor and predict the therapeutic efficacy and toxicity of BNCT alone or combined with other strategies. Besides, there is a brief comment on the introduction of accelerator-based neutron sources in BNCT. These sources would expand the clinical BNCT services to more patients, and would help to make BNCT a standard treatment modality for various types of cancer. Radiobiological BNCT studies have been of utmost importance to make progress in BNCT, being essential to design novel, safe and effective clinical BNCT protocols.

show abstract

“…Although the efficacy of NCT has not been confirmed in randomized phase 3 trials, several reports showed promising results for glioblastoma ( 25 , 26 ) and head and neck cancers ( 27 ) including a recent phase 2 trial ( 28 ) of boron neutron capture therapy for recurrent or locally advanced head and neck cancer that lead to a recent approval of NCT devices by the Japanese counterpart of the FDA. In addition, there are new critical developments that might improve the chance of successful trials of NCT: 1) the introduction of an accelerator-based neutron source that allows location of NCT facilities in hospitals ( 29 ); 2) progress in boron delivery agents and formulations, including nanotechnology ( 30 ); and 3) possible use of other nuclides and their combinations ( 31 , 32 ) to be activated by neutrons ( 33 ).…”

Section: Physicsmentioning

confidence: 99%

Moving Forward in the Next Decade: Radiation Oncology Sciences for Patient-Centered Cancer Care

Coleman¹,

Buchsbaum

Prasanna

et al. 2021

JNCI Cancer Spectrum

View full text Add to dashboard Cite

In a time of rapid advances in science and technology the opportunities for radiation oncology are undergoing transformational change. The linkage between and understanding of the physical dose and induced biological perturbations are opening entirely new areas of application. The ability to define anatomic extent of disease and the elucidation of the biology of metastases has brought a key role for radiation oncology for treating metastatic disease. That radiation can stimulate and suppress subpopulations of the immune response makes radiation a key participant in cancer immunotherapy. Targeted radiopharmaceutical therapy delivers radiation systemically with radionuclides and carrier molecules selected for their physical, chemical and biochemical properties. Radiation oncology usage of “big data” and machine learning/artificial intelligence adds the opportunity to markedly change the workflow for clinical practice while physically targeting and adapting radiation fields in real time. Future precision targeting requires multi-dimensional understanding of the imaging, underlying biology and anatomical relationship among tissues for radiation as spatial and temporal “focused biology”. Other means of energy delivery are available as are agents that can be activated by radiation with increasing ability to target treatments. With broad applicability of radiation in cancer treatment, it is a necessity for effective cancer care, opening a career path for global health serving the medically underserved in geographically isolated populations as a substantial societal contribution addressing health disparities. Understanding of risk and mitigation of radiation injury make it an important discipline for and beyond cancer care including energy policy, space exploration, national security and global partnerships.

show abstract

Status of low-energy accelerator-based BNCT worldwide and in Argentina

Cited by 20 publications

References 23 publications

Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting Moiety for Boron Neutron Capture Therapy

Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting Moiety for Boron Neutron Capture Therapy

Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

Moving Forward in the Next Decade: Radiation Oncology Sciences for Patient-Centered Cancer Care

Contact Info

Product

Resources

About