Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting Moiety for Boron Neutron Capture Therapy
Masahiro Nishikawa,
Jie Yu,
Heon Gyu Kang
et al.
Abstract:Boron neutron capture therapy (BNCT), advanced cancer treatment utilizing nuclear fission of 10B atom in cancer cells, is attracting increasing attention. As 10B delivery agent, sodium borocaptate (10BSH), has been used in clinical studies along with L‐boronophenylalanine. Recently, 10BSH has been conjugated with lipids, polymers or nanoparticles to increase selectivity to and the retentivity in tumor. In this work, we designed the anticancer nanoformulations for BNCT consisting of poly(glycerol) functionalize… Show more
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