Status of Circulating Lipid Profile in Human Uterine Cervical Carcinoma before and after Therapy.

Abstract

To study the status of circulating lipid components in human uterine cervical carcinoma, we collected blood from patients with different stages of uterine cervical carcinoma before and after treatment and also from a control population. Serum lipid was isolated; and the total lipid and their components such as total cholesterol, high-density lipoprotein (HDL)3 cholesterol, HDL3 cholesterol, phospholipids, triglycerides, free fatty acids, and lipid-bound sialic acid were determined. Some of the lipid components like phospholipids, triglycerides, free fatty acids, and lipid-bound sialic acid were found to be increased in advanced stages (stages III and IV) of carcinoma, when compared with the values for control subjects. Some of the altered lipid parameters were adjusted to near normal levels after radiotherapy and radiotherapy combined with chemotherapy. The increase in some of the lipid components might have been due to the elevated activities of lipolytic enzymes.

Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

“…This was in contrast to results of studies of oral cancer and lipid profile by Chawda et al (2011);Dabrowa et al (2011);Singh et al (2013). However the TC value was comparable and HDL-C value was not comparable to the studies of cervical cancer and lipid profile by Ravichandran et al (1996);Preetha et al (2005). The lipid parameters following treatment cannot be concluded as the number of cases were few.…”

“…Following radiotherapy/tumour resection/combined therapy altered lipid parameters reverted back (Ravichandran et al, 1996;Preetha et al, 2005). The cholesterol content of cancerous cervical tissue was roughly double that of normal human cervical tissue, altering the surface activity which in turn alters cell adhesion and metastases (Preetha et al, 2005;2007).…”