“…Calcium signaling plays a role in many neuron cell processes (Perea et al, 2016) related to protein kinases (Kurniawan et al, 2018), intracellular messenger IP3, SERCA pumps, AMPA and NMDA agonists (Kurniawan, 2015a), affected the synaptic plasticity in the form of LTD (Kurniawan, 2015b). Changes in synaptic plasticity that are influenced by neurotransmitters, glutamate, and AMPA are associated with seizures and epilepsy (Barker-Haliski & Steve White, 2015; Bonansco & Fuenzalida, 2016;Göl et al, 2019;Guli et al, 2016;Han et al, 2016;Husna & Kurniawan, 2018;Jarero-Basulto et al, 2018;Kryukov et al, 2016;Plasticity et al, 2017;T. Yu Postnikova et al, 2017;T Y Postnikova et al, 2017;Zubareva et al, 2018).…”