Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012

Abstract

Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

Anticancer activity of diterpenes and steroids from Eunicella singularis against two- and threedimensional breast cancer cell models

“…Therefore, over the past few decades, scientists made significant efforts to isolate new marine-derived natural products [38][39][40][41]. Until now, among marine sources, invertebrates have been the mainstream source in marine-derived drug discovery, contributing approximately to 65% of the marine natural compounds, serving as promising sources of new anticancer agents in preclinical development [42]. The objective of this study was to determine the anticancer effect of two diterpenes (palmonine F and palmonine D) and three steroids (cholesta-5,22-dien-3β-ol, stigmasterol and 5α-cholest-5-en-3β-ol), isolated from the Mediterranean gorgonian E. singularis, on the human breast cancer MCF7 cell line.…”

Antibacterial and anticancer activity of marineStreptomyces parvus: optimization and application

“…[50] Furthermore, marine natural products exhibit a wide range of biological activities. [51] Anti-biofouling activity of S. parvus Figure 6 shows the inhibitory activity of S. parvus crude extract on bacterial biofilm formation. The crude extract reduced the density of the bacterial cells and acted as an anti-biofouling agent.…”

Secondary Metabolites from Marine Sources: Review

“…Günümüzde gelişen dalış tekniklerinin önemli katkısı ile araştır-malar devam etmektedir. [4][5][6][7][8][9] Günümüze kadar yapılan çalışmalarda izole edilen sekonder metabolitlerin biyoaktivitelerine bakıldığında; antikanser etki %56 (2, 10,11 Yeryüzünün %70'ini okyanuslar kaplamaktadır ve bu oran yeryüzünün %97'lik su kaynağını sağlar. Bu ince kara-deniz kesişim noktası, gezegen üzerinde üretkenliğin ve çeşitliliğin en fazla olduğu çevredir.…”

“…Deniz bilimcilerin öngörülerine göre, mercan kayalıkları ya da derin deniz tabanı gibi mutlak ekosistemlerdeki biyoçeşitlilik tropikal yağmur ormanlarındaki çeşitlilikten çok daha fazladır. 11 Deniz canlılarının kısıtlı alanlarda birlikte ve yoğun olarak yaşama-ları, onların yaşamlarını bir hayli karmaşık ve rekabetçi yapmıştır. Mercan, sünger, tunikatların yanı sıra ve çeşitli diğer omurgasızlar gibi sesil makroskobik organizmalar sürekli kaldıkları yaşam alanlarında savaşmak durumundadırlar.…”