Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor

Lenz, F. A.; Normand, Sharon‐Lise T.; Kwan, Hon C.; Andrews, Daniel J.; Rowland, L. H.; Jones, Mark W.; Seike, Masato; Lin, Yu-Tao; Tasker, Ronald R.; Dostrovsky, J. O.; Lenz, Y. E.

doi:10.1002/mds.870100315

“…Serebral metabolizmada NAA'nın rolü ile ilgili önemli, çalışmalar mevcuttur (40,41). NAA sağlam nöronal doku göstergesi olarak kabul edilmektedir.…”

Section: Discussionunclassified

The Role of Ceruloplasmin in Neurodegeneration in Parkinson’s Disease

Gürer¹,

Aydın²,

Gökçe³

et al. 2016

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3

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Amaç: İdiyopatik Parkinson hastalığında (İPH) oksidatif stres nöronal hücre ölümü üzerinde majör role sahiptir. Serüloplazmin ferrooksidaz aktivitesi ile ferröz demiri ferrik forma okside eder ve böylece hücrenin DNA, lipid ve protein bileşenlerini oksidatif hasardan korur. Bizim çalışmamızda proton manyetik rezonans spektroskopi (H-1 MRS) ile serüloplazmin eksikliğinin nörodejenerasyon üzerindeki etkisi araştırılmıştır. Gereç ve Yöntem: İPH tanılı 23 hasta ve 12 sağlıklı kontrol olguda iki yanlı putamen tek voksel H-1 MRS yöntemiyle incelendi. Her iki grupta N-asetil aspartat (NAA), kreatin (Cr) ve kolin (Cho) pik değerleri ve serum serüloplazmin düzeyleri belirlendi. Bulgular: İPH hastalarında semptomatik ekstremitenin kontralateral (KL) putaminal bölge NAA/Cho ve NAA/Cr oranı kontrol grubuna kıyasla anlamlı derecede düşüktü. Ayrıca İPH grubunda KL NAA/Cho ve NAA/Cr oranları ipsilateraline (İL) göre anlamlı derecede düşüktü (p<0,001). Semptomatik ekstremitenin İL putaminal bölgeye ait metabolit oranları karşılaştırıldığında sağlıklı kontrol ile İPH grubu arasında anlamlı fark saptanmadı. Serum serüloplazmin seviyeleri kontrol grubu ile karşılaştırıldığında İPH grubunda anlamlı derecede düşük saptandı (p<0,001). İPH grubunda KL putaminal NAA/Cho oranı ile serüloplazmin seviyeleri arasında anlamlı korelasyon saptandı (p=0,011). Sonuç: Çalışmamızda saptanan serum serüloplazmin düşüklüğü ile KL putamen NAA/Cho oranı arasındaki bu korelasyon serbest radikal aracılı nöronal hücre ölümünde serüloplazmin yetersizliğinin katkıda bulunabileceği hipotezini desteklemektedir. Anahtar Kelimeler: İdiyopatik Parkinson hastalığı, proton manyetik rezonans spektroskopi, serüloplazmin Objective: Oxidative stress has been implicated to play a major role in the neuronal cell death in idiopathic Parkinson's disease (IPD). Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form and thus helps prevent oxidative damage to proteins, lipids, and DNA. The aim of this study was to determine the serum ceruloplasmin levels in patients with IPD and evaluate its role in neurodegeneration using hydrogen proton magnetic resonance spectroscopic imaging (H-1 MRSI). Materials and Methods: Twenty-three patients with the IPD and 12 healthy controls were studied using single-voxel H-1 MRSI of the bilateral putamen. The peak ratios of N-acetyl aspartate (NAA) to creatinine (Cr) and choline (Cho) were measured in both groups and serum ceruloplasmin levels were detected. Results: Compared with the controls, the ratios of NAA/Cho and NAA/Cr in putamen contralateral (CL) to the symptomatic limbs were significantly lower in patients with IPD. Also in the IPD group, CL NAA/Cho and NAA/Cr ratios were significantly lower than the ipsilateral (IL) values (p<0.001). There was no significant difference between ratios of metabolites in putamen IL to the symptomatic limbs in the IPD group compared with the healthy controls. The mean serum ceruloplasmin level of IPD patients was significantly lower than that of the control group (...

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“…3). The present population was a subset of the 116 patients (124 thalami) in which microstimulation at 300 Hz evoked mechanical or movement sensations (Ohara et al 2004) and thermal or pain sensations (Ohara and Lenz 2003). We have previously described the response to stimulation along the staircase at sites where pain was evoked in both the present population and a population of patients with chronic pain (Lenz et al 2004).…”

Section: E T H O D Smentioning

confidence: 99%

“…EMG activity was routinely monitored in four muscles on the contralateral arm to assess involuntary movements at the time of the sensory examination (Lenz et al 1988c). The first trajectory targeted Vc because the response of neurons in this region to somatosensory stimulation was the most reliable physiologic landmark with which to guide the operation (Lenz et al 1995b).…”

Section: Recording Protocolsmentioning

confidence: 99%

“…To confirm that responses were reliable, the patient was asked to identify the onset and termination of the stimulus for both actual and sham trials of microstimulation, i.e., verbal cue without microstimulation. This protocol has been validated (Lenz et al 1993) and used in multiple studies of sensations evoked by thalamic microstimulation (Lenz et al 1995a(Lenz et al , 2004.…”

Section: Psychophysical Protocolsmentioning

confidence: 99%

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Mechanisms in Chronic Multisymptom Illnesses

Clauw¹

2008

0

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 5e. TASK NUMBER 5f. WORK UNIT NUMBER REPORT DATE 01-06-2006 REPORT TYPE PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Michigan Ann Arbor, MI 48106-0737 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTESOriginal contains colored plates: ALL DTIC reproductions will be in black and white. ABSTRACTThe overall objectives of this cooperative agreement are to conduct research in pursuit of identifying the physiologic mechanisms responsible for the symptoms of pain, fatigue, and memory difficulties commonly seen in patients with Chronic Multisymptom Illnesses (CMI) (i.e., fibromyalgia, chronic fatigue syndrome, Gulf War Illnesses, etc.); to identify the risk factors for developing these syndromes as well as programs aimed at both preventing these illnesses and treating established cases. These objectives will be achieved through multiple research studies using innovative, technologically advanced (e.g., functional MRI and telemedicine) methodologies in a multidisciplinary environment. Various studies will be conducted to explore all aspects of pain processing, the effects of exercise deprivation and sleep reduction on symptomatology, the ability of exercise and/or cognitive behavioral therapies to alter patients' locus of control for pain, the neurobiological mechanism(s) of acupuncture on analgesia, the presence of hypersensitivity to auditory stimuli, and the effectiveness of cognitive behavioral therapy delivered via telemedicine and the internet. These studies will be conducted on well-characterized cohorts of CMI subjects and healthy controls taken from our burgeoning subject registry. Research will occur over the next 3 years at the University of Michigan, Ann Arbor, MI and Avera Research Institute, Sioux Falls, SD. SUBJECT TERMS INTRODUCTION:Researchers in the Chronic Pain and Fatigue Research Center ...

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“…1) (Ohara and Lenz 2003;Ohara et al 2004). The analysis of thalamic location was based on the borders of the core as illustrated in Fig.…”

Section: Recording Protocolsmentioning

confidence: 99%

Mechanisms in Chronic Multisymptom Illnesses

Clauw¹

2006

0

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 5e. TASK NUMBER 5f. WORK UNIT NUMBER REPORT DATE 01-06-2006 REPORT TYPE PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Michigan Ann Arbor, MI 48106-0737 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTESOriginal contains colored plates: ALL DTIC reproductions will be in black and white. ABSTRACTThe overall objectives of this cooperative agreement are to conduct research in pursuit of identifying the physiologic mechanisms responsible for the symptoms of pain, fatigue, and memory difficulties commonly seen in patients with Chronic Multisymptom Illnesses (CMI) (i.e., fibromyalgia, chronic fatigue syndrome, Gulf War Illnesses, etc.); to identify the risk factors for developing these syndromes as well as programs aimed at both preventing these illnesses and treating established cases. These objectives will be achieved through multiple research studies using innovative, technologically advanced (e.g., functional MRI and telemedicine) methodologies in a multidisciplinary environment. Various studies will be conducted to explore all aspects of pain processing, the effects of exercise deprivation and sleep reduction on symptomatology, the ability of exercise and/or cognitive behavioral therapies to alter patients' locus of control for pain, the neurobiological mechanism(s) of acupuncture on analgesia, the presence of hypersensitivity to auditory stimuli, and the effectiveness of cognitive behavioral therapy delivered via telemedicine and the internet. These studies will be conducted on well-characterized cohorts of CMI subjects and healthy controls taken from our burgeoning subject registry. Research will occur over the next 3 years at the University of Michigan, Ann Arbor, MI and Avera Research Institute, Sioux Falls, SD. SUBJECT TERMS INTRODUCTION:Researchers in the Chronic Pain and Fatigue Research Center ...

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Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor

Cited by 121 publications

References 38 publications

The Role of Ceruloplasmin in Neurodegeneration in Parkinson’s Disease

The Role of Ceruloplasmin in Neurodegeneration in Parkinson’s Disease

Mechanisms in Chronic Multisymptom Illnesses

Mechanisms in Chronic Multisymptom Illnesses

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