Statistical mixture design investigation for extraction and quantitation of aporphine alkaloids from the leaves of <i>Unonopsis duckei</i> R.E. Fr. by HPLC–MS/MS

Rocha, Pablo R. N.; Freitas, Flávio A. de; Angolini, Célio F. F.; Vasconcelos, Lucas-Smith F.; Silva, Alaíde L. B. da; Costa, Emmanoel V.; Silva, Felipe M. A. da; Eberlin, Marcos N.; Bataglion, Giovana A.; Soares, Patrícia Kaori; Koolen, Héctor H. F.

doi:10.1002/pca.2768

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…MDs have been applied to extract compounds from various medicinal plants, such as anthocyanins and phenolic compounds from jabuticaba skin and seed, by mixing solvents [155]; to optimize the activity of total phenolic and flavonoids compounds from mixture herbs Cnestis palala, Urceola micrantha, Labisia pumila, and Microporus xanthopus [157]; optimize the solvent mixture to extract total phenolic content and antioxidant capacity of camu-camu (Myrciaria dubia) seeds [159]; optimize the solvent proportions for extraction of aporphine alkaloids from the leaves of Unonopsis duckei [160]; optimize the extraction of curcuminoids from turmeric using ethyl lactate, ethanol, and water under mild conditions [158]; and optimization of essential oil extraction from Pitanga (Eugenia uniflora L.) leaves with petroleum ether, n-hexane, methanol, and ethanol [156].…”

Section: Application Of Mixture Design In Pharmaceutical Healthmentioning

confidence: 99%

Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis

Galvan

Effting

Cremasco

et al. 2021

Foods

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Design of Experiments (DoE) is a statistical tool used to plan and optimize experiments and is seen as a quality technology to achieve products excellence. Among the experimental designs (EDs), the mixture designs (MDs) stand out, being widely applied to improve conditions for processing, developing, or formulating novel products. This review aims to provide useful updated information on the capacity and diversity of MDs applications for the industry and scientific community in the areas of food, beverage, and pharmaceutical health. Recent works were selected following the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) flow diagram. Data analysis was performed by self-organizing map (SOM) to check and understand which fields of application/countries/continents are using MDs. Overall, the SOM indicated that Brazil presented the largest number of works using MDs. Among the continents, America and Asia showed a predominance in applications with the same amount of work. Comparing the MDs application areas, the analysis indicated that works are prevalent in food and beverage science in the American continent, while in Asia, health science prevails. MDs were more used to develop functional/nutraceutical products and the formulation of drugs for several diseases. However, we briefly describe some promising research fields in that MDs can still be employed.

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Section: Application Of Mixture Design In Pharmaceutical Healthmentioning

confidence: 99%

Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis

Galvan

Effting

Cremasco

et al. 2021

Foods

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“…Various analytical methods has been reported for the estimation of active phytoconstituents. It includes TLC , HPTLC , HPTLC/MS , HPLC , HPLC/MS/MS , LC/MS, GC/MS and GC/MS/MS.As per world health organisation recommendation High‐performance liquid chromatography coupled with UV detector is best suited for the pharmaceutical analysis. HPLC have been used widely in research and development and quality control sections in pharmaceutical industries .…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the liquid chromatographic methods for simultaneous analysis of quercetin and salicin in an anti‐psoriasis polyherbal formulation

Qadir

Aqil

Ali

et al. 2020

Separation Science Plus

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Smilax china L. and Salix alba are the medicinal plants of interest due to the presence of various therapeutic activities of these plants such as antiinflammatory, anti-diabetic, anti-psoriatic and digestive properties. Smilax china and Salix alba consists of bioactive marker Quercetin and Salicin, respectively. In the present study, a simple, rapid, reliable and accessible high-performance thin-layer chromatography method has been established for simultaneous quantification of quercetin and salicin. High-performance thin-layer chromatography fingerprinting was carried out on pre-coated Silica G60 F254 plates with toluene: ethyl acetate: formic acid (3.5:6.0:1.0 v/v/v) as mobile phase. The developed plates were scanned and quantified at two different λ max 380 and 275 nm. The drug samples were satisfactorily resolved with Rf 0.61 ± 0.02 for quercetin and 0.07 ± 0.03 for salicin. The method was validated for linearity, accuracy, precision, and specificity. The limits of detection and quantification for quercetin and salicin were 2.0 and 6.00 µg per band and 6.00 and 30.0 µg per band respectively. The developed high-performance thin-layer chromatography method can be implemented for the concurrent estimation of quercetin and salicin for routine quality control of herbal drugs containing these phytoconstituents.

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Purification, identification and in silico models of alkaloids from Nardostachys jatamansi — bioactive compounds for neurodegenerative diseases

Krishnan

Vairamani

Dhanabalan

et al. 2022

Biomass Conv. Bioref.

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Statistical mixture design investigation for extraction and quantitation of aporphine alkaloids from the leaves of Unonopsis duckei R.E. Fr. by HPLC–MS/MS

Abstract: The integration of simplex centroid model and quantification by HPLC-MS/MS is promising. Statistical optimisation of the alkaloid extraction and application of selective, sensitive and robust HPLC-MS/MS method will contribute to quality control applications in phytotherapeutic medicines.

Cited by 4 publications

References 19 publications

Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis

Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis

Comparative evaluation of the liquid chromatographic methods for simultaneous analysis of quercetin and salicin in an anti‐psoriasis polyherbal formulation

Purification, identification and in silico models of alkaloids from Nardostachys jatamansi — bioactive compounds for neurodegenerative diseases

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