“…62 Given the increased inflammation seen in patients with psoriasis, it is not surprising that these patients are at an increased risk for meeting criteria of the metabolic syndrome (OR = 1.7-5.3). 9,11,63 Numerous groups have published reports of psoriasis being associated with increased serum insulin levels, 62 diabetes (OR = 1.5-2.5), 5,6,8,9,11,[64][65][66][67][68] hypertension (OR = 1.1-3.3), 5,6,8,9,11,12,65,66,69 hypertriglyceridemia, 9,58-60,63,65 abdominal obesity, 63 or decreased HDL-C. 9,58,59,70 Additionally, hypercholesterolemia, 58,59,65 increased serum LDL-C, 58,59 and generalized hyperlipidemia (OR = 1.3-3.1) 8,11,69 have been reported to be more common in patients with psoriasis. Although the best and greatest amount of evidence supports these associations, it should be noted that a few studies have failed to demonstrate an association between psoriasis and increased insulin, 70 glucose, 63,70 triglycerides, 70 total cholesterol, 60,70 LDL-C, 70 hypertension, 63 or low HDL-C. 60,63 Understanding hormonal and cytokine biology can also ...…”