Obesity and psoriasis: From the Medical Board of the National Psoriasis Foundation

Bremmer, Samuel; Voorhees, Abby S. Van; Hsu, Sylvia; Korman, Neil J.; Lebwohl, Mark; Young, Melodie; Bebo, Bruce F.; Blauvelt, Andrew

doi:10.1016/j.jaad.2009.09.053

Cited by 107 publications

(100 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The finding of higher BMI values correlates with the expectations and is consistent with previously published results 25,26 . Antigliadin antibodies (AGA) are diagnostic markers of celiac disease and several studies have reported an association between psoriasis and AGA, with improvements seen in the severity of psoriasis in patients on a gluten-free diet 27,28 .…”

Section: Discussionsupporting

confidence: 93%

Risk factors for comorbidities in Czech psoriatic patients: Results of a hospital-based case-control study

Votrubová¹,

Jůzlová²,

Šmerhovský³

et al. 2014

BIOMED PAP

View full text Add to dashboard Cite

Background.Psoriasis is now known to be associated with multiple other diseases/comorbidities -including the metabolic syndrome, atherosclerosis and gastrointestinal diseases which are all significantly higher in psoriasis patients. Research results however are highly variable and the conclusions are ambiguous. As no similar study has been performed to date in Czech psoriatic patients, this study aimed at identifying risk factors and early stages of selected diseases/comorbidities in the patients. Methods and Results. The study was designed as a hospital-based case-control study. 131 patients with chronic plaque psoriasis formed the cases and 267 patients with other skin disorders formed the controls. A comparison was made of basic demographic and anthropometric indicators, metabolic parameters, the presence of specific antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, t-TG, AGA) and non-specific signs of gastrointestinal diseases. The chi squared, MWU tests and binary logistical model were used to evaluate the data. The results showed significant differences (P<0.05) for the following parameters: blood pressure, waist circumference, weight, BMI values, leucocytes values, HDL cholesterol level, glycemia and gliadine antibody IgA level. All differences were to the detriment of psoriasis patients. In the binary logistical model the following parameters were associated with psoriasis: diastolic blood pressure, leucocyte value and glycemia. For all variables included in the logistical model P≤0.001. Conclusions. The results were coherent and consistent with existing data. They indicate that psoriasis is interconnected with hypertension, higher BMI and a decreased level of HDL cholesterol. These parameters have been clearly demonstrated as risk factors for the development of cardiovascular diseases. Higher levels of gliadine IgA antibodies are one of the diagnostic markers of celiac disease. Higher values of leukocytes may be interpreted as a nonspecific indicator of gastrointestinal inflammatory diseases. The associations between psoriasis and diastolic blood pressure, BMI value and glycemia are statistically significant in the binary logistic regression model. Care for psoriatic patients should focus especially on secondary prevention of predisposing diseases.

show abstract

Section: Discussionsupporting

confidence: 93%

Risk factors for comorbidities in Czech psoriatic patients: Results of a hospital-based case-control study

Votrubová¹,

Jůzlová²,

Šmerhovský³

et al. 2014

BIOMED PAP

View full text Add to dashboard Cite

show abstract

“…For example, in those patients who have an inflammatory process already ongoing, saturated fatty acids could produce an exacerbated inflammatory state in macrophages, generating more proinflammatory cytokines and contributing to the maintenance of inflammation. In the same line of thought, it has been described that obese patients with psoriasis are more difficult to treat than non-obese individuals (43,44). Several trials have demonstrated that psoriatic patients have partially recovered after weight loss and that increases in weight worsen the symptoms (43, 44).…”

Section: Discussionmentioning

confidence: 99%

Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages

Valdearcos¹,

Esquinas²,

Meana

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…In addition, weight gain and higher waist circumference, hip circumference and WHR were associated with an increased incidence of psoriasis [14]. Obesity is more common in patients with difficult to treat psoriasis, and a higher BMI may affect the response to anti-psoriatic therapy [15]. Intriguingly, observational studies demonstrate that patients with a higher BMI may have more severe psoriasis, and weight loss has been associated with improvements in PASI scores in patients treated with biological agents; the underlying mechanisms are incompletely understood [16].…”

mentioning

confidence: 99%

“…Intriguingly, observational studies demonstrate that patients with a higher BMI may have more severe psoriasis, and weight loss has been associated with improvements in PASI scores in patients treated with biological agents; the underlying mechanisms are incompletely understood [16]. Similarly, several case reports describe the improvement and near resolution of psoriasis following weight loss achieved through intestinal bypass surgery [15]. In a 24 week randomised trial, the consequences of moderate weight loss were examined in obese patients with moderate to severe chronic plaque psoriasis treated with ciclosporin.…”

mentioning

confidence: 99%

Glucagon-like peptide-1 (GLP-1) receptor agonists, obesity and psoriasis: diabetes meets dermatology

Drucker

Rosen

2011

Diabetologia

View full text Add to dashboard Cite

Type 2 diabetes mellitus is characterised by beta cell failure, which frequently develops in the setting of insulin resistance. Inflammation contributes to the pathophysiology of type 2 diabetes by impairing insulin action in peripheral tissues and via reduction of beta cell function. Inflammation may also play an important role in the development of complications that arise in patients with type 2 diabetes. Hence, the antiinflammatory actions of commonly used glucoselowering drugs may contribute, indirectly, to their mechanisms of action and therapeutic benefit. Herein we highlight the anti-inflammatory actions of glucagonlike peptide-1 (GLP-1), which exerts direct and indirect actions on immune function. The observations that GLP-1 receptor agonists exert anti-inflammatory actions in preclinical studies, taken together with case reports linking improvements in psoriasis with GLP-1 receptor agonist therapy, illustrates the emerging clinical implications of non-classical anti-inflammatory actions of incretin-based therapeutics.

show abstract

Obesity and psoriasis: From the Medical Board of the National Psoriasis Foundation

Cited by 107 publications

References 83 publications

Risk factors for comorbidities in Czech psoriatic patients: Results of a hospital-based case-control study

Risk factors for comorbidities in Czech psoriatic patients: Results of a hospital-based case-control study

Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages

Glucagon-like peptide-1 (GLP-1) receptor agonists, obesity and psoriasis: diabetes meets dermatology

Contact Info

Product

Resources

About