Statistical and epidemiologic data on urologic cancer

Silverberg, Edwin

doi:10.1002/1097-0142(19870801)60:3+<692::aid-cncr2820601541>3.0.co;2-k

Cited by 65 publications

(20 citation statements)

References 78 publications

(13 reference statements)

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“…In contrast to other reports [8][9][10] that had shown that low grade superficial tumors comprised 80% of all TCC of the bladder, our study revealed that only 35.7% of TCC in the Riyadh area were superficial, while approximately 65% had evidence of muscle invasion at the time of initial presentation. Friedel et al 11 suggested that all bladder cancers progress through a sequence of events in which initially superficial tumors, if left untreated, become invasive and infiltrate the lamina propria, the muscularis mucosa and finally penetrate the perivesical fat.…”

Section: Discussioncontrasting

confidence: 99%

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

Kattan

Yousef

Onuora

et al. 1994

Annals of Saudi Medicine

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In a retrospective study, the records of 54 Saudi patients constituting 35.2% of the total number of patients with bladder carcinoma presenting to Riyadh Central Hospital over a seven year period (1985G to 1992G) were reviewed. Eighty-one percent of the patients were habitants of the Central Province of Saudi Arabia. Their mean age was 60 ± 14.8 years. Male to female ratio was 5:1; gross hematuria was the main presenting symptom, occurring in 90% of patients. Twenty-four patients presented six months or more after the onset of symptoms. Upper tract deterioration was noted in 50% of cases at the time of initial presentation. A total of 76.9% of bladder tumors were transitional cell carcinoma, 19.2% were squamous cell carcinoma and 3.8% were poorly differentiated. Only 29% were superficial tumors while 71% were at least muscle-invading at presentation. The majority of tumors were of high grade. This study shows that high grade muscle-invading transitional cell carcinoma is the most frequent histological pattern of bladder tumor in Riyadh Central Hospital. Delay in patient presentation associated with a tendency for invasion of bladder tumor in this region resulted in a high percentage of incurable disease.

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Section: Discussioncontrasting

confidence: 99%

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

Kattan

Yousef

Onuora

et al. 1994

Annals of Saudi Medicine

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“…7 Since the 1950s, the incidence of bladder cancer in Western countries, including Spain, has increased by 50%. 8 Smoking constitutes the major risk factor for bladder cancer, although PAH exposure is also a risk factor. [9][10][11][12] Polycyclic aromatic hydrocarbons exposure occurs through many occupations or mixtures [such as diesel-engine (classified as group 1) or gasoline-engine (classified into group 2B)], as evaluated by IARC.…”

Section: Introductionmentioning

confidence: 99%

Exposure to polycyclic aromatic hydrocarbons (PAHs) and bladder cancer: evaluation from a gene-environment perspective in a hospital-based case-control study in the Canary Islands (Spain)

Boada

Henríquez-Hernández

Navarro

et al. 2014

International Journal of Occupational and Environmental Health

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Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to bladder cancer. Objective: To evaluate the role of PAHs in bladder cancer, PAHs serum levels were measured in patients and controls from a case-control study. Methods: A total of 140 bladder cancer patients and 206 healthy controls were included in the study. Sixteen PAHs were analyzed from the serum of subjects by gas chromatography-mass spectrometry. Results: Serum PAHs did not appear to be related to bladder cancer risk, although the profile of contamination by PAHs was different between patients and controls: pyrene (Pyr) was solely detected in controls and chrysene (Chry) was exclusively detected in the cases. Phenanthrene (Phe) serum levels were inversely associated with bladder cancer (OR50.79, 95%CI50.64-0.99, P50.030), although this effect disappeared when the allelic distribution of glutathione-S-transferase polymorphisms of the population was introduced into the model (multinomial logistic regression test, P50.933). Smoking (OR53.62, 95%CI51.93-6.79, P,0.0001) and coffee consumption (OR51.73, 95%CI51.04-2.86, P50.033) were relevant risk factors for bladder cancer. Conclusions: Specific PAH mixtures may play a relevant role in bladder cancer, although such effect seems to be highly modulated by polymorphisms in genes encoding xenobiotic-metabolizing enzymes.

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“…A ocorrência de mutações no epitélio vulvar, no decorrer do processo de envelhecimento, é a melhor explicação para o aumento significativo da incidência de cân-cer vulvar após os 75 anos de idade (14,41,67). Um método para determinação de clonalidade, baseado na inativação (metilação) do gene receptor de androgênio, situado no cromossomo X, foi desenvolvido recentemente para caracterizar este epitélio (3,76).…”

Section: Estudos De Clonalidade De Lesões Precursoras Hpv Positivas Eunclassified

Etiopatogenia do câncer vulvar

Pinto¹

2002

J. Bras. Patol. Med. Lab.

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Statistical and epidemiologic data on urologic cancer

Cited by 65 publications

References 78 publications

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

Exposure to polycyclic aromatic hydrocarbons (PAHs) and bladder cancer: evaluation from a gene-environment perspective in a hospital-based case-control study in the Canary Islands (Spain)

Etiopatogenia do câncer vulvar

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