Statistical analysis of factors affecting survival after glioblastoma multiforme

Takeuchi, Kazuo; Hoshino, Kazuhiko

doi:10.1007/bf01401926

Cited by 50 publications

(10 citation statements)

References 15 publications

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“…The latter findings, however, are at variance with those of other studies of factors affecting prognosis in which the period of survival tended to be longer in cases where tumor was located in the frontal or centroparietal areas rather than in the temporal area [14] and with that from the UCLA experience [10] in which the group of patients with grade IV tumor treated with two therapy modes later did worse than those who received only one.…”

Section: Discussioncontrasting

confidence: 56%

Intracranial astrocytoma in elderly patients

1992

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Because little is known about intracranial astrocytomas occurring in those in the increasing geriatric population, twenty-three persons evaluated at the university affiliated hospitals over a 26-year period are reported. Progressive mental dysfunctions and motor deficits were the most common manifestations of disease. Glioblastoma multiforme was the predominant (87%) histopathologic diagnosis. The overall median period of survival in 21 evaluable individuals was four (range 0 to 15) months. Median survival was longer in patients who were more functional, who had tumors located in the temporal lobes of the brain, and who received more than one treatment modality. The absence of intercurrent disease or being in a younger 'elderly' age group was not associated with an improvement in prognosis. The poor survival of this group as well as the survivals quoted in the literature for those with glioblastoma multiforme demands a new therapeutic approach.

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Section: Discussioncontrasting

confidence: 56%

Intracranial astrocytoma in elderly patients

1992

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“…In BTSG studies, patients with a duration of symptoms greater than 6 months have a mean death rate half that of those with duration of symptoms less than 6 months. In another study (Takeuchi and Hoshino 1977) an approximately linear relationship between the length of preoperative and survival periods was found. A history of epilepsy is also related to a better prognosis (Scott andGilbert 1980, Walker et al 1980).…”

Section: ) Clinical Findingsmentioning

confidence: 91%

Indications for Surgery in the Management of Gliomas

Cohadon

1990

Advances and Technical Standards in Neurosurgery

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“…A diagnosis of glioblastoma continues to carry a grim prognosis; median survival is approximately 50 weeks. However, a few patients (about 3%) live more than 5 years [1,4,7,[8][9][10][11][12][13]. Given the relatively few patients who are thought to have survived more than 5 years and the generally nihilistic attitude towards the subject as a whole, it is understandable that no large series of long-term survivors has been studied [11, [14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Long-term survival in a patient with supratentorial glioblastoma: clinical considerations

1998

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Glioblastoma, a malignant tumor of neuroepithelial origin, is relatively uncommon in childhood, during which it accounts for 7%-9% of brain tumors. A few patients (about 3%) live more than 5 years. We report a 13-year-old girl who was admitted because one month earlier she had begun to present headache and diplopia. Brain computed tomography (CT) showed a right frontal tumor. At operation, complete excision of the visible tumor was performed. Histologic examination showed that the tumor was a glioblastoma multiforme. The patient underwent 52 Gy of external beam radiotherapy to the enhancing tumor mass plus 3-cm border, and chemotherapy with nitrosourea (BCNU). Fourteen years, 9 months later, the patient presents neither neurological deficits nor radiological relapse. We confirm that younger age, the one immutable prognostic factor, supports a particularly aggressive approach to the treatment of glioblastomas.

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Statistical analysis of factors affecting survival after glioblastoma multiforme

Cited by 50 publications

References 15 publications

Intracranial astrocytoma in elderly patients

Intracranial astrocytoma in elderly patients

Indications for Surgery in the Management of Gliomas

Long-term survival in a patient with supratentorial glioblastoma: clinical considerations

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