Long-term survival in a patient with supratentorial glioblastoma: clinical considerations

Cervoni, Luigi; Celli, Paolo; Salvati, Maurizio

doi:10.1007/bf02427606

Cited by 9 publications

(6 citation statements)

References 32 publications

(28 reference statements)

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“…The majority of patients reported in case reports and case series that are thought to have been cured (from a clinical perspective) are in the younger age categories, which is consistent with the results of this study [3,4,5,6,30]. Vertosick and Selker [31] published a series of patients treated at their institution and suggested that cure may occur in GBM patients after 4 years of survival due to the low rates of recurrence (1 of 22 patients with GBM and high-grade gliomas).…”

Section: Discussionsupporting

confidence: 81%

“…Studies are showing that only 2.2% of patients are estimated to survive 3 years or more after diagnosis of a GBM, a figure that is nevertheless set to increase in the near future due to recent therapeutic advances [1,2]. However, there are reports that some patients can live for more than 10 years after diagnosis and potentially achieve cure [3,4,5,6,7]. A common feature amongst those patients who live longer than 10 years is that they are typically younger than 40 years at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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The Cure Fraction of Glioblastoma Multiforme

Smoll¹,

Schaller²,

Gautschi³

2012

Neuroepidemiology

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Background and Purpose: This study presents a statistical model to explore the presence of a population-based cure fraction in populations with a GBM. Patients and Methods: Data for this study was obtained from the Surveillance, Epidemiology and End-Results (SEER) database. Relative survival measures were modelled using non-mixture cure fraction models. Results: The extraction and subsequent period modeling of the dataset resulted in a final total of 11,189 patients and a total of 10,289 years of patient follow-up (between 2001 and 2006). The cure fraction of young adults is expected to be 12% (95% CI 7–16), which is estimated to occur at a minimum time of 10 years post diagnosis. Interpretation: The data, using population-based cure fraction models, indicate that a possibility for cure appears to be present in the young adult population, and occurs at 10 years after diagnosis. Because of the biological and statistical features of this patient population, it is appropriate to study GBM populations using cure fraction models.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

The Cure Fraction of Glioblastoma Multiforme

Smoll¹,

Schaller²,

Gautschi³

2012

Neuroepidemiology

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“…Genotyping was added to the new WHO classification of the central nervous system in 2016 (14), which makes accurate pathological grading as well as molecular and genotyping of glioma patients before surgery more urgent. In the treatment of glioma, conventional surgical excision plus radiotherapy can only prolong the average life span by 9–12 months (15) and does not effectively improve the prognosis of the patients. An important reason is the malignant biological behavior of gliomas, which includes the formation of neovascularization, malignant proliferation of cells, and invasive growth of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the angiogenesis of C6 glioma in rats based on CT quantitative parameters

et al. 2018

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Background Glioma is the most common neoplasm that is neuroepithelial in nature. However, Spectral computed tomography (CT) has rarely been reported to detect angiogenesis in tumors. Purpose To investigate the value of multi-parameter spectral CT for the detection of angiogenesis in C6 glioma in rats. Material and Methods Fifteen male Wistar rats were seeded with C6 glioma cells in the right basal ganglia and spectral CT-enhanced scanning was performed at days 7, 10, and 14 after the C6 glioma cells were seeded. The spectral CT parameters were measured in three areas: the solid tumor; the peritumoral area; and the contralateral mirror area. After different periods of scanning, the rats’ brain tissue was stained with HE and CD105 immunohistochemical staining. Different periods of spectral CT quantitative parameters and pathological images were analyzed. Results The spectral CT parameter and CD105 among the solid tumor, peritumoral area, and contralateral mirror area were significantly different: monochromatic CT value (211.30 ± 34.67 HU, 119.16 ± 13.31 HU, and 55.59 ± 7.87 HU, P < 0.001); CD105 (16.14 ± 1.91, 6.79 ± 1.31, and 2.50 ± 0.51, P < 0.001); spectral curve slope (10.35 ± 1.89, 5.33 ± 0.87, 0.88 ± 0.26, P < 0.001); iodine (water) value (49.75 ± 9.02, 26.04 ± 4.32, 4.36 ± 1.18, P < 0.001). CD105 correlated strongly with the CT value at 65 keV (correlation coefficient r = 0.98, P < 0.001). Conclusion Multi-parameter spectral CT can reflect the formation of tumor angiogenesis in rat C6 glioma to a certain extent and can be used as an effective means to evaluate glioma.

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“…collective of patients is homogeneous with respect to localization (superficial cortical tumors) and age (no patients <20 years). This is an important point, since glioblastomas in childhood may show a more favourable clinical behaviour (22) and tumors from other sites such as deep-seated tumors may exhibit a different expression profile (23). Due to the standard postoperative treatment (local radiation with 60 Gy), even effects of different treatment modalities on survival time could be excluded.…”

Section: Discussionmentioning

confidence: 99%

The morphology of perinecrotic tumor cell nuclei in glioblastomas shows a significant relationship with survival time

Nafe

Franz²,

Schlote³

et al. 2006

Oncol Rep

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A deeper knowledge about histopathological criteria with a significant impact on the prognosis of patients with glioblastomas is worthwhile, since these patients may show a considerable difference in the time of survival. Investigation of the morphology of perinecrotic tumor cell nuclei is a promising approach, because the expression of specific molecules in these cells has been associated with a more aggressive behaviour of the tumors. In our series of patients with documented clinical course, 11 patients had a survival of at least 24 months and we compared this group with a group of 10 patients with maximum survival of 12 months. Digital microscopic image analysis was performed in paraffin sections from the primary surgical specimen. Three hundred perinecrotic tumor cell nuclei per case and 300 nuclei per case from tumor cells lying more distant from the tumor necroses ('distant zone' nuclei) were measured. The ratio for the numerical nuclear density between both types of nuclei was significantly larger in cases with short survival indicating a more pronounced nuclear density of perinecrotic nuclei in relation to the 'distant zone' nuclei in these tumors. In cases with long survival, on the contrary, perinecrotic tumor cells exhibited an only slightly larger numerical density compared with 'distant zone' nuclei. Mean values and standard deviations from parameters of nuclear shape (Fourier-amplitudes) had significantly smaller values in short-time survivors indicating a tendency towards a more circular nuclear shape with less pronounced intratumoral variation in that group. Based on the morphometric results, all cases could be correctly reclassified as short-or long-time survivors by means of cross-validated discriminant analysis. In conclusion, the results confirm significant morphological differences between tumors from patients with short and with long survival regarding morphology of both types of tumor cell nuclei. It seems likely, that histomorphometry of tumor cell nuclei could be a promising approach for the assessment of the individual prognosis of patients with glioblastomas.

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Long-term survival in a patient with supratentorial glioblastoma: clinical considerations

Cited by 9 publications

References 32 publications

The Cure Fraction of Glioblastoma Multiforme

The Cure Fraction of Glioblastoma Multiforme

Quantifying the angiogenesis of C6 glioma in rats based on CT quantitative parameters

The morphology of perinecrotic tumor cell nuclei in glioblastomas shows a significant relationship with survival time

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