Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability

Massaro, Marika; Zampolli, Antonella; Scoditti, Egeria; Carluccio, Maria Annunziata; Storelli, Carlo; Distante, Alessandro; Caterina, Raffaele De

doi:10.1093/cvr/cvp375

Cited by 104 publications

(84 citation statements)

References 43 publications

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“…Studies showed that lovastatin has a potent anti-inflammatory activity since it inhibits carrageenan-induced peritonitis and paw edema. Although these findings are consistent with studies showing these effects of statins in many inflammation models, most of them were carried out with other statins, mainly simvastatin (Dantas et al, 2010;Massaro et al, 2010;. Studies demonstrate that simvastatin provides a highly effective therapy in treating murine Collagen-Induced Arthritis (CIA), a surrogate model for human Rheumatoid Arthritis (RA).…”

Section: Discussionsupporting

confidence: 77%

Effect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in Mice

Mirhadi¹

2011

American Journal of Animal and Veterinary Sciences

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Problem statement:The 3-Hydroxy-3-Methyl Glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality. Their lipid-lowering actions are by reversible and competitive inhibition of the enzyme HMG-CoA reductase, a precursor of cholesterol. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels, such as pain and inflammatory. The aim of this study was to determination the effect of intraperitoneally injection of different doses of lovastatin on pain and inflammatory response induced by formalin in mice. Approach: Mice were divided into 9 groups randomly: the first group received saline normal (ip) (saline group); the second group received Carboxymethylcellulose (CMC) 0.5% (ip) (vehicle group) and the next groups received respectively different doses of lovastatin (1, 5, 10, 20, 40, 80 and 100 mg kg daily −1 ) for 4 days (ip) before formalin test. After intrapawly injection of formalin, the time of hind paw biting and licking time measured in 5 min interval for an hour. Results: Results showed that formalin induces biphasic pain response (the first phase: 0-5 min and the second phase 15-40 min after injection). Intraperitoneal injection of lovastatin showed significant (p<0.05) decrease of pain responses in the first and the second phase in a dose dependently manner. Conclusion: According to our results, lovastatin has analgesic and anti-inflammatory effects on mice. Nevertheless, new studies must be carried out in order to determine the beneficial effects of statins in treatment of pain and inflammatory.

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Section: Discussionsupporting

confidence: 77%

Effect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in Mice

Mirhadi¹

2011

American Journal of Animal and Veterinary Sciences

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“…In this study PTZinduced seizure threshold in control mice was 35.48±1.39 mg kg −1 and pitavastatin increased PTZinduced seizure threshold in a dose dependently manner. Anti-nociceptive and anti-inflammatory effects of statins have been shown in different experimental animal models of pain and inflammatory and clinical studies (Dantas et al, 2010;Massaro et al, 2010;Nezic et al, 2009;Sparrow et al, 2001;Weitz-Schmidt et al, 2001), but so fare effects of statins on epilepsy are very limited (Rangel et al, 2005;Lee et al, 2008). Results of this study showed that pitavastatin has beneficial neuroprotective effects on PTZ seizure model in mice that in agreement with a recent study that reported an effective neuroprotective action of statins after an acute brain injury and epilepsy (Daimon et al, 2004;Lee et al, 2008;Rangel et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant Effect of Pitavastatin in Mice Induced by Pentylenetetrazole

Mirhadi¹

2011

American Journal of Animal and Veterinary Sciences

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Problem statement:The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipidlowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of pitavastatin on PTZ-induced seizure threshold in mice. Approach: Mice were divided into 9 groups randomly: the first group received saline normal (ip) (control group); the second group received Carboxymethylcellulose (CMC) 0.5% (ip) (vehicle group) and the next groups received respectively different doses of pitavastatin (1, 5, 10, 20, 40, 80 and 100 mg kg daily . Intraperitoneal injection of pitavastatin showed significant (p<0.05) increase of PTZ-induced seizure threshold in a dose dependently manner. Conclusion: According to our results, pitavastatin has anticonvulsant effects on mice. Nevertheless, new studies must be carried out in order to determine the beneficial effects of statins in treatment of epilepsy.

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“…Hypercholesterolemia is correlated with increases in platelet reactivity (Opper et al, 1995). These abnormalities are associated with increases in the cholesterol/phospholipid ratio in platelets.…”

Section: Atorvastatin and Platelets Functionmentioning

confidence: 99%

“…These abnormalities are associated with increases in the cholesterol/phospholipid ratio in platelets. Additional potential mechanisms include increases in thromboxane A2 (TXA2) biosynthesis (Notarbartolo et al, 1995), platelet α 2 -adrenergic receptor density (Baldassarre et al, 1997) and platelet cytosolic calcium (Le Quan Sang et al, 1995). Atorvastatin had a marked reduction effect on platelet aggregation (Tekten et al, 2004).…”

Section: Atorvastatin and Platelets Functionmentioning

confidence: 99%

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Pharmacological Effects of Atorvastatin in Platelet Function and Plaque Rupture

Natarajan¹,

Kanna²,

Sahl³

et al. 2016

J App Pharm Sci

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Platelets are a prime reason for causing cardiovascular disease (CVD). After atherosclerotic plaque rupture, platelets can form pathogenic, formation of blood clot which leads to various cardiovascular events. The beneficial effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A) reductase inhibitors reduces CVDs clinically. The objective of this review is the pharmacological benefit of atorvastatin in CVD by platelets and plaque rupture due to high levels of cholesterol.

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Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability

Cited by 104 publications

References 43 publications

Effect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in Mice

Effect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in Mice

Anticonvulsant Effect of Pitavastatin in Mice Induced by Pentylenetetrazole

Pharmacological Effects of Atorvastatin in Platelet Function and Plaque Rupture

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