Statins and the Risk for Coronary in-Stent Restenosis in Diabetic Patients

Abstract

Diabetes mellitus is considered to be an independent risk factor for the progression of coronary artery disease, due to the associated pro-atherosclerotic status, and also an important predictor of poor outcomes after both coronary artery bypass grafting and percutaneous coronary intervention. Even in the contemporary era of newer-generation stents and despite remarkable technological advances, in-stent restenosis is still a major problem. The aim of our study was to identify risk factors for restenosis in the first year after stent deployment in 95 diabetic patients with coronary heart disease. Our results suggest that a larger stent diameter and the use of statins positively influence the risk of in-stent restenosis in the first year after stent implantation. Systemic statin therapy should be considered in all interventional treated diabetic patients, in order to reduce the risk of in-stent restenosis, particularly in high-risk patients. RezumatDiabetul zaharat este considerat a fi un factor de risc independent pentru progresia bolii coronariene ischemice (BCI), datorită statusului pro-aterosclerotic și, de asemenea, un predictor important al prognosticului terapiilor de reperfuzie coronariană. Chiar și în epoca contemporană, a stenturilor de "nouă generație" și în ciuda progreselor tehnologice remarcabile, restenozarea in-stent rămâne o problemă semnificativă. Scopul studiului nostru a fost identificarea factorilor de risc pentru restenoză în primul an după instalarea stentului la un grup de 95 de pacienți diabetici cu BCI. Rezultatele noastre sugerează că diametrul mai mare al stentului și utilizarea statinelor influențează favorabil riscul de restenozare in-stent în primul an după implantare. Terapia sistemică cu statine trebuie luată în considerare la toți pacienții diabetici cu intervenție, pentru a reduce riscul de restenozare in-stent.

Coronary Computed Tomography Angiography-Derived Modified Duke Index Is Associated with Peri-Coronary Fat Attenuation Index and Predicts Severity of Coronary Inflammation

“…Additionally, this approach enhances prognostic accuracy beyond what traditional risk factors provide, highlighting the critical role of inflammation in comprehensive cardiovascular risk evaluation [34]. Beside inflammation, we should also take into account that CAD displays some differences regarding risk factors and pharmacological treatment, which may influence the outcome [35,36].…”

Cytomegalovirus Infection and Cardiovascular Risk in a Monocentric Romanian Adult Patient Group

“…The cholesterol-lowering drugs like statins may be important during treatments for reactivations of CMV infection, especially in the elderly and patients with other associated diseases like diabetes, in order to decrease the associated cardiovascular complications [16,34]. Moreover, severe cardiovascular adverse events are decreased by 50% in diabetic patients under the treatment with statins due to their pleiotropic effects including lipid-lowering, anti-inflammatory, antioxidant, antithrombotic and antimitotic effect [27]. The study aims to highlight the impact of chronic cytomegalovirus infection on health status and assess the cardiovascular risk in chronically infected patients and the importance of monitoring these patients for initiating the optimal therapeutic approach.…”

Ascorbate Inhibits the Endothelium-Dependent Hyperpolarization Mediated Relaxation in Resistance Arteries

“…Very few studies on ASC and EDH-mediated EDR have used isolated rabbit iliac artery [14], isolated perfused bovine ciliary bed [24,25], and isolated perfused rat mesenteric arterial bed [25]. Given the sustained broad interest in EDH-mediated EDR [13] and our sustained interest in endothelial function and dysfunction [9,19,[30][31][32] and in various aspects of oxidative stress [20,22,34,35], we decided to test the effect of ASC upon EDH-mediated EDR in isolated small mesenteric arteries. One previous study has examined EDH-mediated EDR in isolated small mesenteric arteries [33], but ours differs in some aspects, and we discuss their relevance.…”