Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers

Lin, Cheng‐Jui; Chen, Wan-Ming; Shia, Ben‐Chang; Wu, Szu‐Yuan

doi:10.1111/1759-7714.15009

Cited by 2 publications

(1 citation statement)

References 53 publications

(130 reference statements)

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“…Previous studies have indicated an association between statin use and a low risk of IS in HNC patients after RT. [42][43][44] A study indicated that oral antithrombotic therapy did not significantly mitigate the risk of IS. 45 In this study, we discovered that NPC patients with CAS and non-NPC patients with VAS were at elevated risks of IS.…”

Section: Discussionmentioning

confidence: 99%

Vertebral and Carotid Artery Stenosis after Irradiation Both Raise Ischemic Stroke Risk in Head and Neck Cancer Patients

Jiang,

Chang,

Huang

et al. 2024

Preprint

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Purpose: To study the risk of ischemic stroke (IS) following carotid (CAS) or vertebral artery stenosis (VAS) in head and neck cancer (HNC) patients after radiation therapy (RT). Methods: We included HNC patients who received RT between 2010 and 2023. They underwent regular head and neck imaging monitoring to evaluate cancer recurrence at the department of radiation-oncology and vascular examinations at the department of neurology. Patients were initially divided into nasopharyngeal carcinoma (NPC) and non-NPC groups. The primary outcome was the occurrence of IS after RT, and the secondary outcomes included the development of >50% CAS or >50% VAS after RT. Cox regression and Kaplan?Meier analyses were conducted to compare the outcomes of the study groups. Further analysis was conducted based on the presence or absence of >50% CAS or >50% VAS during the follow-up period. Results: Of the 1,423 HNC patients, 19%, 6.8%, and 2.3% developed >50% CAS, >50% VAS, and IS during a 58-month follow-up. Compared with the NPC group, the non-NPC group exhibited a higher incidence of >50% CAS (25.4% vs. 10.7%, p<0.001) and >50% VAS (8.8% vs. 4.3%, p<0.001), but similar risks of IS. In patients with HNC, >50% CAS (adjusted hazard ratio [HR]=3.21, 95% confidence interval [CI]=1.53-6.71), and >50% VAS (adjusted HR=2.89, 95% CI=1.28-6.53) were both the independent predictors of IS. In the patients with NPC, >50% CAS was an independent predictor of anterior circulation IS (adjusted HR=4.39, 95% CI=1.17-16.47). By contrast, >50% VAS emerged as a predictor of posterior circulation IS in both the NPC (adjusted HR=15.02, 95% CI=3.76-60.06) and non-NPC groups (adjusted HR=13.59, 95% CI=2.21-83.46). Conclusion: HNC patients with >50% CAS or >50% VAS after RT had an increased risk of IS within their corresponding vascular territory. CAS is a major predictor of IS in NPC patients, whereas VAS is a major predictor of IS in both NPC and non-NPC patients.

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Section: Discussionmentioning

confidence: 99%

Vertebral and Carotid Artery Stenosis after Irradiation Both Raise Ischemic Stroke Risk in Head and Neck Cancer Patients

Jiang,

Chang,

Huang

et al. 2024

Preprint

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Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers

et al. 2023

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BackgroundBetel nut chewing involves the chewing of areca nuts or betel quid (areca nuts wrapped in betel leaves), which is associated with an increased risk of esophageal squamous cell carcinoma (ESCC). Statins have anticancer properties. We investigated the association between statin use and ESCC risk in betel nut chewers.MethodsThe study included 105 387 betel nut chewers matched statin users and nonusers. Statin use was defined as the use of ≥28 cumulative defined daily doses (cDDDs) of statin. The primary outcome was incidence of ESCC.ResultsThe incidence rate of ESCC was significantly lower in statin users than in nonusers (2.03 vs. 3.02 per 100 000 person‐years). Statin users had a lower incidence rate ratio of 0.66 for ESCC (95% confidence interval [CI]: 0.43–0.85) relative to nonusers. After potential confounders were adjusted for, statin use was determined to be associated with a reduced risk of ESCC (adjusted hazard ratio [aHR], 0.68; 95% CI: 0.51–0.91). A dose–response relationship was observed between statin use and ESCC risk; the aHRs for statin use at 28–182 cDDDs, 183–488 cDDDs, 489–1043 cDDDs, and > 1043 cDDDs were 0.92, 0.89, 0.66, and 0.64, respectively.ConclusionStatin use was revealed to be associated with a reduced risk of ESCC in betel nut chewers.

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Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers

Cited by 2 publications

References 53 publications

Vertebral and Carotid Artery Stenosis after Irradiation Both Raise Ischemic Stroke Risk in Head and Neck Cancer Patients

Vertebral and Carotid Artery Stenosis after Irradiation Both Raise Ischemic Stroke Risk in Head and Neck Cancer Patients

Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers

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