2014
DOI: 10.1371/journal.pone.0103909
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Abstract: Experimental studies suggested that statins attenuate vascular AT1 receptor responsiveness. Moreover, the augmented excessive pressor response to systemic angiotensin II infusions in hypercholesterolemic patients was normalized with statin treatment. In 12 hypercholesterolemic patients, we tested the hypothesis that statin treatment attenuates angiotensin II-mediated vasoconstriction in hand veins assessed by a linear variable differential transducer. Subjects ingested daily doses of either atorvastatin (40 mg… Show more

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Cited by 4 publications
(2 citation statements)
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“…The role of statins on RAS components also have been observed in clinical trials as showed by Schindler et al (2014) that identified, for the first time, an increase of Ang-1-7 level in hypercholesterolemic subjects after atorvastatin treatment. Altogether, those responses suggest an important role of statins on RAS components, including a decrease in Ang-II and, apparently, an upregulation in the ACE2/Ang-1-7 axis.…”
Section: The Role Of Statins On Ras Components and Atherosclerosismentioning
confidence: 89%
“…The role of statins on RAS components also have been observed in clinical trials as showed by Schindler et al (2014) that identified, for the first time, an increase of Ang-1-7 level in hypercholesterolemic subjects after atorvastatin treatment. Altogether, those responses suggest an important role of statins on RAS components, including a decrease in Ang-II and, apparently, an upregulation in the ACE2/Ang-1-7 axis.…”
Section: The Role Of Statins On Ras Components and Atherosclerosismentioning
confidence: 89%
“…For example, treatment of cholesterol-fed rabbits with atorvastatin increased the expression of ACE2 in the heart and kidney [ 84 ]. Treatment of rats with rosuvastatin after vascular balloon injury upregulated the expression of ACE2 and then the formation of Ang (1-7) [ 85 ]. In a clinical trial, it was shown that atorvastatin treatment of hypercholesterolemic subjects increased Ang (1-7)levels [ 86 ].…”
Section: Effect Of Statins On Ras Pathwaysmentioning
confidence: 99%