Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7

Silva, Gabriela M.; França-Falcão, Maria S.; Calzerra, Natália Tabosa Machado; Luz, Mickael Sousa da; Gadelha, Danilo D. A.; Balarini, Camille M.; Queiroz, Thyago M.

doi:10.3389/fphys.2020.01067

Cited by 44 publications

(46 citation statements)

References 85 publications

(115 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It also plays a role in the adhesion of mononuclear cells to the arterial endothelium and recruitment of mononuclear cells by stimulating the increase in CAM expression of TNF-α, which is released as a result of stimulation of AT1R with AngII, in combination with IL-6 [35]. One study reported that AngII induced monocyte chemotactic protein-derived protein expression (MCPIP1) via an AMPK/p38 MAPK-dependent pathway [36]. Increased MCPIP1 expression contributes to atherosclerotic plaque formation by triggering apoptosis in macrophages [37].…”

Section: Atherosclerosismentioning

confidence: 99%

Role of the Renin-Angiotensin-Aldosterone System in Various Disease Processes: An Overview

Gelen¹,

Kükürt²,

Şengül³

2021

Renin-Angiotensin Aldosterone System

View full text Add to dashboard Cite

The renin-angiotensin-aldosterone system is a physiological system that plays an important role in the regulation of blood pressure and body water-electrolyte balance, in which the kidney, liver and lungs play a role in its activation. This system comes into play in various diseases such as the cardiovascular, renal, pulmonary and nervous system where blood pressure and fluid-electrolyte balance may change. The purpose of this study, which is presented in line with this information, is to explain the working principle of this system, how this system is activated, how it comes into play in the mentioned diseases, and what kind of results occur.

show abstract

Section: Atherosclerosismentioning

confidence: 99%

Role of the Renin-Angiotensin-Aldosterone System in Various Disease Processes: An Overview

Gelen¹,

Kükürt²,

Şengül³

2021

Renin-Angiotensin Aldosterone System

View full text Add to dashboard Cite

show abstract

“…Endothelial damage and inflammation allow for the migration of monocytes and macrophages to the site of injury and the formation of foam cells. [13][14][15]. Additionally, stimulation of inflammatory mediators also promotes smooth muscle cell (SMC) thickening, stiffness of vessels and forms a fibrous cap on the atherosclerotic plaque (Figure 2) [16].…”

Section: Atherosclerosis and Endothelial Dysfunctionmentioning

confidence: 99%

“…It occurs due to the gradual buildup of atherosclerotic plaque within the wall of arteries leading to reduced oxygen delivery to cardiac myocytes. It comprises a clinical spectrum based on the degree of luminal narrowing and the activation of the atherosclerotic plaque [13,14]. The RAAS plays a vital role in the pathogenesis of CAD.…”

Section: Ischemic Heart Diseasementioning

confidence: 99%

See 1 more Smart Citation

The Role of the Renin-Angiotensin-Aldosterone System in Cardiovascular Disease: Pathogenetic Insights and Clinical Implications

Capric¹,

Chandrakumar²,

Celenza-Salvatore³

et al. 2021

Renin-Angiotensin Aldosterone System

View full text Add to dashboard Cite

Increased attention has been placed on the activation of the renin-angiotensin-aldosterone system (RAAS) and pathogenetic mechanisms in cardiovascular disease. Multiple studies have presented data to suggest that cardiac and arterial stiffness leading to adverse remodeling of both the heart and vasculature leads to the various pathological changes seen in coronary artery disease, heart failure (with preserved and reduced ejection fractions), hypertension and renal disease. Over-activation of the RAAS is felt to contribute to these structural and endocrinological changes through its control of the Na+/K+ balance, fluid volume, and hemodynamic stability. Subsequently, along these lines, multiple large investigations have shown that RAAS blockade contributes to prevention of both cardiovascular and renal disease. We aim to highlight the known role of the activated RAAS and provide an updated description of the mechanisms by which activation of RAAS promotes and leads to the pathogenesis of cardiovascular disease.

show abstract

“…Two G protein-coupled receptors mediate the effects of Ang- [1][2][3][4][5][6][7][8]. Excessive Ang- [1][2][3][4][5][6][7][8] activity at the angiotensin type 1 receptor (AT 1 R) leads to hypertension, inflammation, atherogenesis and tissue fibrosis (72,95). The angiotensin type 2 receptor (AT 2 R) plays a counter-regulatory role in AT 1 R actions, especially in the female (90,91).…”

Section: Introductionmentioning

confidence: 99%

Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19

Stanic

Maddox

Souza

et al. 2021

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting-enzyme-2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin-system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin-type-1-receptor. Therefore, we conducted Ovid MEDLINE and Embase database searches of basic science studies investigating the impact of the biological variable of sex on ACE2 expression and regulation from 2000, the year ACE2 was discovered, through December 31, 2020. Out of 2131 publications, we identified 853 original research articles on ACE2 conducted in primary cells, tissues and/or whole mammals excluding humans. The majority (68.7%) of these studies that cited the sex of the animal were conducted in males, while 11.2% were conducted solely in females; 9.26% compared ACE2 between the sexes, while 10.8% did not report the sex of the animals used. General findings are that sex-differences are tissue-specific and when present, are dependent-upon gonadal state. Renal, cardiac and adipose ACE2 is increased in both sexes under experimental conditions that model co-morbidities associated with worse COVID-19 outcomes including hypertension, obesity, and renal and cardiovascular diseases; however, ACE2 protein was generally higher in the males. Studies in Ace2- knockout-mice indicate ACE2 plays a greater role protecting the female from developing hypertension than the male. Studying the biological variable of sex in ACE2 research provides an opportunity for discovery in conditions involving RAS-dysfunction and will shed light on sex-differences in COVID-19-severity.

show abstract

Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7

Cited by 44 publications

References 85 publications

Role of the Renin-Angiotensin-Aldosterone System in Various Disease Processes: An Overview

Role of the Renin-Angiotensin-Aldosterone System in Various Disease Processes: An Overview

The Role of the Renin-Angiotensin-Aldosterone System in Cardiovascular Disease: Pathogenetic Insights and Clinical Implications

Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19

Contact Info

Product

Resources

About