Statin treatment decreases serum angiostatin levels in patients with ischemic heart disease

Tykhomyrov, А. A.; Nedzvetsky, V. S.; Bardachenko, N.; Grinenko, T. V.; Kuryata, Olexandr

doi:10.1016/j.lfs.2015.05.008

Cited by 7 publications

(8 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, patients with psoriasis had a significantly higher level of angiostatin than controls. Moreover, we found a significant and moderate correlation between CRP and angiostatin among psoriasis patients, which agrees with previous studies carried among patients with ischaemic heart disease 28 …”

Section: Discussionsupporting

confidence: 93%

Assessment of selected angiogenesis markers in the serum of middle‐aged male patients with plaque psoriasis

Socha

Kiciński

Feldo

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Local angiogenesis accompanies inflammation in psoriasis‐affected skin. To determine the serum concentrations of selected pro‐ and anti‐angiogenic factors and their interrelationships in patients with plaque psoriasis. The study included 41 men diagnosed with psoriasis, aged 43.5 ± 11.7 years. The Psoriasis Area and Severity Index score was 23.4 ± 5.2 points. The control group consisted of 38 healthy, age‐matched men. The levels of pro‐angiogenic cytokines and angiogenesis inhibitors, including fibroblast growth factor 1 (FGF‐1), vascular endothelial growth factor A (VEGF‐A), endostatin, and angiostatin, were determined from the serum of patients and controls using enzyme‐linked immunosorbent assays. Compared with controls, patients with psoriasis had a significantly lower concentration of FGF‐1 (P = .01) but higher concentrations of endostatin (P = .04) and angiostatin (P = .02). The concentration of VEGF‐A was also higher in patients with psoriasis but not significantly (P = .25). The concentration of C‐reactive protein (CRP) was significantly higher among patients with psoriasis than controls (P < .0001). Among controls, CRP concentrations did not correlate significantly with the concentrations of FGF‐1, VEGF‐A, endostatin, or angiostatin. Among patients with psoriasis, CRP concentrations correlated moderately with the concentrations of VEGF‐A (r = .35; P = .02) and angiostatin (r = .31; P = .04). The concentration of VEGF‐A correlated positively with PASI (r = .05; P = .0009) and BSA values (r = .39; P = .01). Psoriasis is associated with an altered systemic balance between pro‐angiogenic and anti‐angiogenic factors. The increase in serum angiogenesis inhibitors may be associated with unfavorable changes in the development of coronary collateral circulation. However, the clinical significance of this has not yet been established.

show abstract

Section: Discussionsupporting

confidence: 93%

Assessment of selected angiogenesis markers in the serum of middle‐aged male patients with plaque psoriasis

Socha

Kiciński

Feldo

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Local and systemic angiostatin up-regulation takes place in hyperglycemia, metabolic syndrome, several autoimmune disorders, and inflammatory processes, thereby sustaining associated vascular complications [28,4749]. Our recent data are in line with the abovementioned reports because we have revealed that simvastatin lipidlowering treatment of patients with ischemic heart disease results in the dramatic decrease of serum angiostatin that correlates significantly with the antiinflammatory and antiathero genic effects of statin therapy [30]. There is lack of information about angiostatin production and its role in nervous tissue.…”

Section: Dynamics Of Clinical and Laboratory Parameters In Patients Wsupporting

confidence: 85%

“…The most recent study of ElAshmawy et al [29] has demonstrated that elevated levels of another angiogenesis suppressor, endostatin, are associated with coronary artery calcification in type 2 diabetic patients. In our previous studies, we have shown the possibility of pharmacological targeting of circulating angiosta-tin levels by Larginine and simvastatin in patients with coronary heart disease and chronic heart failure [30,31]. To our knowledge, no prior studies have exami ned effects of CDPcholine on angiostatin levels in ischemic stroke associated with atrial fibrillation.…”

Section: Fig 1 Cytidine Diphosphate-choline (Cdp-choline or Citicomentioning

confidence: 99%

Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke

Tykhomyrov¹,

Kushnir²,

Nedzvetsky³

et al. 2019

Ukr.Biochem.J.

View full text Add to dashboard Cite

Ischemic stroke is considered as one of the most frequent and severe complications of atrial fibrillation. The present study was undertaken to examine whether post-insult treatment with cytidine diphosphate-choline (CDP-choline, or citicoline) affects serum levels of the angiogenesis inhibitor angiostatin and neurospecific proteins as markers of brain damage in patients with cerebral ischemia associated with atrial fibrillation. Thirty-three patients with a diagnosis of acute ischemic stroke received citicoline sodium by intravenous infusions (1,000 mg daily for 14 days) in addition to the standard treatment (basic group). Twentyfive patients with the same pathologies, who received only standard therapy, were enrolled in the study as a control group. Serum content of angiostatin and neurospecific proteins, namely neurofilament heavy subunit (NF-H) and glial fibrillary acidic protein (GFAP), was measured by immunoblotting at the basal level and after the treatment. Citicoline treatment caused significant decreases in serum levels of angiostatin (by 40% vs. basal level, P < 0.05), GFAP (by 61%, P < 0.01), and the NF-H subunit (by 19%, P < 0.05) and had no effect on the serum albumin content. In contrast, there were no statistically significant differences between baseline levels of the studied protein markers and their content after the treatment period in the control group. These findings indicate for the first time that CDP-choline protects both astrocytes and neurons and improves angiogenic capacity through down-regulation of angiostatin in post-ischemic patients with atrial fibrillation after acute ischemic stroke. Further studies are needed to test associations between serum levels of these biomarkers, clinical outcomes, and treatment efficacy of stroke. K e y w o r d s: atrial fibrillation, ischemic stroke, citicoline, angiostatin, neurofilaments (NFs), glial fibrillary acidic protein (GFAP).I schemic stroke is a complex multifactorial and polygenic disease. It is generally accepted that one of the major risk factors for ischemic stroke is atrial fibrillation [1]. Past studies indicate that fibrillation of the atrium produces stasis of blood, which causes thrombus formation and embolism in the brain [2,3]. More recent investigations suggest that the pathogenesis of stroke in atrial fibrillation is more complicated and involves other factors in addition to the dysrhythmia [4,5]. It is well acknowled ged that atrial fibrillation is the most prevalent car-diac arrhythmia, affecting approximately 12% of the population worldwide. Being an independent risk factor for stroke, atrial fibrillation is associated with high mortality, morbidity, and socioeconomic burden [6]. Therefore, stroke prevention with appropriate prophylaxis remains central to management of both atrial fibrillation and its neurological complications. However, the search for effective neuroprotectors remains frustrating, and the current therapeutic protocols remain suboptimal. Ideally, sufficient protection must be provided to the ischemic brain a...

show abstract

“…Protein samples (50 μg/track) were run in 518% denaturing polyacrilamide gels (PAAG) and transferred onto nitrocellulose membrane (GE Healthcare, Amersham Bioscience) with 0.45 μm pore diameter by means of electroblot. After transferring, membranes were blocked in 5% m/v nonfat dry milk for 90 min at 37 °C and probed with primary antibody, which were obtained as described previously [15,18]. Briefly, isolated and purified product of Plg limited digesting by porcine elastase, which comprises the first three kringle domains (K1-3), was used as an antigen for rabbit immunization.…”

Section: Methodsmentioning

confidence: 99%

“…AS suppresses angiogenesis by inhibiting endothelial cell proliferation, migration and can even promote endothelial apoptosis [1113]. As a rule, AS circulates in abundance in plasma of patients with different cancers and inflammatory states, however, the changes in blood concentrations of this molecule are not always consistent with the alterations of their tissue levels [14,15]. To our knowledge, no reports have examined content of Plg/AS in the breast benign neoplasms.…”

Section: It Is Known That Benign Breast Tissue Exhibit Relatively Lowmentioning

confidence: 99%

Plasminogen and angiostatin levels in female benign breast lesions

Tykhomyrov¹,

Вовчук²,

Grinenko³

2015

Ukr.Biochem.J.

View full text Add to dashboard Cite

Statin treatment decreases serum angiostatin levels in patients with ischemic heart disease

Cited by 7 publications

References 47 publications

Assessment of selected angiogenesis markers in the serum of middle‐aged male patients with plaque psoriasis

Assessment of selected angiogenesis markers in the serum of middle‐aged male patients with plaque psoriasis

Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke

Plasminogen and angiostatin levels in female benign breast lesions

Contact Info

Product

Resources

About