Plasminogen and angiostatin levels in female benign breast lesions

Tykhomyrov, А. A.; Вовчук, И. Л.; Grinenko, T. V.

doi:10.15407/ubj87.05.103

Cited by 2 publications

(2 citation statements)

References 34 publications

(37 reference statements)

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“…It is worth to underline, that the formation of β-stacked protein aggregates in the living body in itself leads to severe consequences associated with the disruption of the normal functioning of a number of biological systems. A special group of tumor-producing substan ces are the tumors' restrictors, that more or less effectively block the interactions essential for metastasis and invasion [27,28]. Similarly to biofilms, the reaching of the three-dimensional tumor's size causes the cells' differentiation, formation of feeding vessels and changes in the character and intensity of the local metabolism.…”

Section: Too Much Coincidences To Be Casualmentioning

confidence: 99%

Tumors and biofilms: too much coincidences to be casual

Verevka

Voroshylova

2018

Biopolym. Cell

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Section: Too Much Coincidences To Be Casualmentioning

confidence: 99%

Tumors and biofilms: too much coincidences to be casual

Verevka

Voroshylova

2018

Biopolym. Cell

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“…There are many studies on angiostatin. Tykhomyrov's research found that angiostatin is an effective angiogenesis inhibitor and anti-inflammatory molecule, which plays a vital role in the pathophysiology of non-cancerous breast diseases (6). The expression and significance of Liang angiostatin, vascular endothelial growth factor and matrix metalloproteinase-9 in cerebral ischemiareperfusion was measured in diabetic rats (7).…”

Section: Introductionmentioning

confidence: 99%

Experimental study on anti angiogenesis of recombinant mouse angiostatin gene in mice with gallbladder carcinoma

Wang

Jiang

Zhu

2022

Cell Mol Biol (Noisy-le-grand)

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Gallbladder cancer is one of the gastrointestinal tumors with an extremely poor prognosis. Its incidence rate is gradually increasing worldwide, and the rate of radical resection surgery is extremely low. Not sensitive to radiotherapy and chemotherapy, with a very poor prognosis. This study aimed to investigate whether the recombinant mouse angiostatin gene transfected anti-angiogenic gallbladder cancer cells can express angiostatin protein with the activity of inhibiting the growth of vascular endothelial cells and the inhibitory effect on the growth of gallbladder cancer. The recombinant mouse angiostatin gene eukaryotic expression plasmid was transfected into the gallbladder cancer cell line by applying liposome LIPOFECTAMINE 2000, and its activity was detected by vascular endothelial cell proliferation analysis. The results show that angiostatin can inhibit the growth of transplanted gallbladder cancer, and as the number of injections increases, the inhibition rate of gallbladder cancer growth also increases. At the end of the experiment, the total inhibition rate of gallbladder cancer growth reached 95% 5%, 20%, 30%, 40% gradually increase. Therefore, angiostatin has potential clinical application value in gene therapy of gallbladder cancer.

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Plasminogen and angiostatin levels in female benign breast lesions

Cited by 2 publications

References 34 publications

Tumors and biofilms: too much coincidences to be casual

Tumors and biofilms: too much coincidences to be casual

Experimental study on anti angiogenesis of recombinant mouse angiostatin gene in mice with gallbladder carcinoma

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