Giulia Maria Camerino, Maria Antonietta Pellegrino, Lorenza Brocca, Claudio Digennaro, Diana Conte Camerino, Sabata Pierno, Roberto Bottinelli
AbstractStatins and fibrates can cause myopathy. To further understand the causes of the damage we performed a proteome analysis in fast-twitch skeletal muscle of rats chronically treated with different hypolipidemic drugs. The proteomic maps were obtained from extensor digitorum longus (EDL) muscles of rats treated for 2-months with 10mg/kg atorvastatin, 20mg/kg fluvastatin, 60mg/kg fenofibrate and control rats. The proteins differentially expressed were identified by mass spectrometry and further analysed b…
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