Biochemical Pharmacology volume 81, issue 8, P1054-1064 2011 DOI: 10.1016/j.bcp.2011.01.022 View full text
Giulia Maria Camerino, Maria Antonietta Pellegrino, Lorenza Brocca, Claudio Digennaro, Diana Conte Camerino, Sabata Pierno, Roberto Bottinelli

Abstract: AbstractStatins and fibrates can cause myopathy. To further understand the causes of the damage we performed a proteome analysis in fast-twitch skeletal muscle of rats chronically treated with different hypolipidemic drugs. The proteomic maps were obtained from extensor digitorum longus (EDL) muscles of rats treated for 2-months with 10mg/kg atorvastatin, 20mg/kg fluvastatin, 60mg/kg fenofibrate and control rats. The proteins differentially expressed were identified by mass spectrometry and further analysed b…

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