Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats

Jansone, Baiba; Dzirkale, Zane; Jēkabsons, Kaspars; Piļipenko, Vladimirs; Beitnere, Ulrika; Māgure, Ingrīda; Skumbiņš, Raimonds; Klētnieks, Uģis; Vanaga, Ilona; Muceniece, Ruta; Kluša, Vija

doi:10.1515/prolas-2016-0003

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…Polyprenols are a well-known class of natural substances that have mostly been studied for their anti-inflammatory [1], hepatoprotective [2], and immunomodulating functions [3]. Recently, polyprenols were also tested in muscle strength and coordination experiments in combination with widely used drugs statins, reducing their side effects in vivo and in patients [4,5]. Polyprenols are hydrophobic molecules of natural long-chain isoprenoid alcohols.…”

Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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The needles of conifer trees are one of the richest sources of natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) were observed in the ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram of Siberian fir with the most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% of the total polyprenol yield). Abies sibirica L. polyprenol solubility and incorporation efficiency into liposomes were studied in various commercially available lecithin mixtures (Phosal IP40, Phosal 75SA, and Lipoid P45). The resulting multilamellar polyprenol liposomes were morphologically characterized by Light and Transmission Electron Microscopy, and the liposome size was discovered to be polymodal with the main peak at 1360 nm (90% of the volume). As polyprenols are fully soluble only in lipids, a liposomal formulation based upon co-solubilization and a modified ethanol injection method of polyprenols into the ethanol-phospholipid system was developed for the entrapment and delivery of polyprenols for potential commercial applications in food supplement and cosmetic industries.

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Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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“…Their hepatoprotective abilities are described as well (Swiezewska et al, 2005;Yang et al, 2011). Polyprenols protect muscles from statin-induced muscle damage in rats by improving their muscle strength and power (Jansone et al, 2016). Similar effects were found in statin-using patients, for whom a combination of polyprenols and CoQ10 increased creatine phosphokinase (CFK) levels and improved muscle symptoms associated with statin-induced myopathy (Latkovskis et al, 2016).…”

Section: Introductionmentioning

confidence: 90%

Polyprenol Liposomes Improve the Efficiency of Oxygen Usage in Well-Trained Amateur Athletes

Ušacka

Plakane

Vanaga

et al. 2022

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Polyprenols are natural substances that are known for their role as cell membrane protectors from peroxidation. However, there is a lack of information about their effect on the performance of athletes. Therefore, we studied the effects of polyprenol on athlete performance. A total of 30 male floorball players participated in this study, 16 of whom were taking 30 mg polyprenol liposome caps and 14 of whom were not. All of the participants underwent VO2max exhaustive incremental cycling testing, before and after the use of polyprenols. VO2peak and other cardiorespiratory variables were measured to evaluate cardiorespiratory adaptation. For the polyprenol users (PU) the oxygen pulse (O2/HR) increased by 0.9 ml/beat, while in the control group (C) decreased by 0.4 ml/beat from before to after the use of polyprenols (p < 0.05). The diastolic pressure (Pdia) decreased by 4 mmHg for the PU, while it increased by 10 mmHg in the C (p < 0.05). The stroke volume (SVc) in the PU increased by 2.9 ml, while that in the C decreased by 7.4 ml (p < 0.05). In conclusion, polyprenols improved oxygen consumption efficiency by increasing SVc and O2/HR.

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“…It is best suited to measure skeletal muscle coordination and endurance (Hoffman and Winder, 2016). The protocol used was according to Jansone et al (2016).The set up was constructed using a stainless steel wire (90 cm length, 2.5 mm in diameter), fixed horizontally between two vertical supports and 60 cm above a soft padded surface. The WHT was carried out on day 35 for groups 1-3 and day 42 for group 4.…”

Section: Wire Hang Test (Wht)mentioning

confidence: 99%

Rosuvastatin ameliorates anxiety but impairs skeletal muscle performance by malondialdehyde and calcium depletion in high fat diet-fed swiss albino mice

Abi,

Matthias,

Saater

2024

J. Afr. Assoc. Physiol. Sci

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Background: The high intake of high calorie, high fat diets (HFD) with an associatedsedentary lifestyle has been linked with a number of neurobehavioral and neuromusculardisorders. This study aimed at investigating the effect of a lipid lowering drug -Rosuvastatin (ROS) on anxiety-like behavior and muscle strength in HFD-fed mice.Methods: The animals were grouped into four (n=5); Group 1 (normal chow and water adlibitum); Group 2 (HFD ad libitum); Group 3 (HFD + ROS); Group 4 (HFD for 5 weeksthen ROS for 1 week). Thereafter, mice were subjected to elevated plus maze (EPM) testand wire hanging test (WHT). Animals were then killed and brain samples homogenizedand assayed for neurotransmitters and antioxidants. The blood samples were assayed forcalcium, uric acid and Malondialdehyde (MDA).Results: The HFD significantly (p<0.05) heightened anxiety in the mice which wasameliorated by ROS. Muscle strength was however decreased with ROS. Brain levels ofdopamine and serotonin were not significantly affected (p<0.05) by ROS likewisesuperoxide dismutase (SOD) and Catalase. Serum calcium and MDA were significantlyreduced by ROS.Conclusions: High fat diet induced anxiety in the animals and improved muscle enduranceon exertion. Rosuvastatin ameliorated the anxiety but reduced muscle strength and theproposed mechanism is suppression of MDA and Calcium functions respectively

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Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats

Abstract: # Corresponding author Contributed by Vija KluðaPolyprenols (PPs)

Cited by 9 publications

References 36 publications

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Polyprenol Liposomes Improve the Efficiency of Oxygen Usage in Well-Trained Amateur Athletes

Rosuvastatin ameliorates anxiety but impairs skeletal muscle performance by malondialdehyde and calcium depletion in high fat diet-fed swiss albino mice

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