Static and dynamic otolith reflex function in people with Parkinson’s disease

Hawkins, Kim; Chiarovano, Elodie; Paul, Serene S.; MacDougall, Hamish G.; Curthoys, Ian S.

doi:10.1007/s00405-020-06446-1

Cited by 7 publications

(9 citation statements)

References 40 publications

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“…The pooled OR of mVEMP was 7.52 ( n = 171; 95% CI = 1.93 to 29.25) with low heterogeneity ( I 2 = 0%) ( Figure 2 ). One study met the inclusion criteria of our meta-analysis, but it was excluded for duplicating the patients of another included study, which was presented with more detailed data [ 26 , 32 ]. The Begg’s tests of the absence rates in the various kinds of VEMPs were not significant, which is consistent with a low or moderate risk of publication bias ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

“… Forest plot of absent VEMP responses in patients with PD: ( A ) the absence rate of cVEMP [ 6 , 7 , 11 , 15 , 22 , 25 , 26 , 27 ]; ( B ) the absence rate of oVEMP [ 7 , 11 , 15 , 26 ]; ( C ) the absence rate of mVEMP [ 11 , 15 ]. …”

Section: Figurementioning

confidence: 99%

“… ( A ) Meta-analysis of cVEMP P13 latency in patients with PD compared with healthy controls [ 6 , 7 , 8 , 11 , 13 , 14 , 15 , 16 , 17 , 22 , 23 , 24 , 25 , 26 , 27 ]; ( B ) meta-analysis of oVEMP P15 latency in patients with PD compared with healthy controls [ 7 , 8 , 11 , 13 , 14 , 15 , 23 , 26 ]; ( C ) meta-analysis of peak-to-peak amplitude of cVEMP in patients with PD compared with healthy controls [ 8 , 11 , 13 , 15 , 16 , 17 , 23 , 24 , 26 , 27 ]; ( D ) Forest plot of AAR of cVEMP in patients with PD compared with healthy controls [ 7 , 8 , 11 , 23 ]. …”

Section: Figurementioning

confidence: 99%

“… Forest plot of absent VEMP responses in patients with PD who fell within 1 year compared with patients with PD who did not fall within 1 year: ( A ) the absence rate of cVEMP [ 13 , 26 ]; ( B ) the absence rate of oVEMP [ 13 , 26 ]. …”

Section: Figurementioning

confidence: 99%

“… ( A ) Sub-group analysis of peak-to-peak amplitude based on age [ 8 , 11 , 13 , 15 , 16 , 17 , 23 , 24 , 26 , 27 ]; ( B ) sub-group analysis of P15 latency based on age [ 7 , 8 , 11 , 23 ]; ( C ) sub-group analysis of peak-to-peak amplitude based on Hoehn and Yahr stage [ 8 , 11 , 13 , 15 , 23 , 26 , 27 ]. …”

Section: Figurementioning

confidence: 99%

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Assessment of Vestibular-Evoked Myogenic Potentials in Parkinson’s Disease: A Systematic Review and Meta-Analysis

2022

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(1) Background: The brainstem plays an essential role in the early stage of Parkinson’s disease (PD), but it is not widely tested in clinical examinations of PD. Vestibular-evoked myogenic potentials (VEMPs) are recognized as fundamental tools in the assessment of brainstem function. The aim of our meta-analysis was to assess the abnormal findings of VEMPs in patients with PD. (2) Methods: Up to 14 February 2022, PubMed, Embase, and Web of Science were searched to evaluate VEMPs in patients with PD in comparison with respective controls. The study protocol was registered at PROSPERO (CRD42022311103). (3) Results: A total of 15 studies were finally included in our meta-analysis. The absence rates of VEMPs in patients with PD were significantly higher than those of control groups (cVEMP: OR = 6.77; oVEMP: OR = 13.9; mVEMP: OR = 7.52). A delayed P13 latency, a decreased peak-to-peak amplitude, and an increased AAR of cVEMP, and a delayed oVEMP P15 latency were also found in patients with PD. (4) Conclusions: Our meta-analysis indicates abnormal VEMP findings in patients with PD, revealing the dysfunction of the brainstem in PD. VEMP tests, especially cVEMP tests, could be a helpful method for the early detection of PD.

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Section: Resultsmentioning

confidence: 99%