State of the pituitary-thyroid system in pregnant rabbits, fetuses, and newborn rabbits

Turakulov, Ya. Kh.; Salakhova, N. S.; Tashkhodzhaeva, T. P.

doi:10.1007/bf00807508

Cited by 3 publications

(3 citation statements)

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“…The hypocholesterolemia was observed in other pregnant animal species including camel and cow (Nath et al, 2005;Saeed et al, 2009). Hemodilution, reduced secretion of lipoprotein from liver, transport of TC to the fetal blood, increase in its use for biosynthesis of steroid hormones, accumulation in maternal tissues, increased excretion of sterols or bile acids in feces (Vasilenko, 2016), decreased its absorption from food (Zilversmit et al, 1972), and high activity of thyroid gland (Turakulov et al, 1977) may be implicated as causative mechanistic pathways for the pregnancy-related hypolipidemia.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Adenosine Deaminase (Ada) Level in Pregnant Ewes in Relation to Liver Function Test and Some Oxidant Indicator

Abou-Khali

2017

Assiut Veterinary Medical Journal

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Pregnancy represents a major challenge to animal based on the analysis of immunological and metabolic responses. Thus, the aim of this study to assess the potential changes in adenosine deaminase (ADA) enzyme activity level, representative indicators of liver function, and some markers of oxidative stress. This study was conducted on 36 Saidi ewes divided into four equal groups (n=9). The first group (non pregnant) was kept as control, while the other three groups were classified according to the time intervals of pregnancy (4-5, 11-12 and 16-17 weeks). The study showed that ADA level exhibited a bimodal pattern with highly significant increase in early pregnancy, decline in mid pregnancy, and further increase in late pregnancy. A significant increase in total protein (TP) was observed at early pregnancy, and returned to the basal level followed by further significant decrease at the late stage of pregnancy. Albumin (ALB) and triglyceride (TG) undergone significant decreased at the late stage. Mean while, total bilrubin (TB), total cholesterol (TC) and aspartate aminotransferase (AST) remained significantly lower than the pre-pregnancy values. The maximum level of gamma-glutamyl-transferase (GGT) appeared at early pregnancy, and the minimum level was observed at the late period. Malondialdhyde (MDA) has undergone a significant reduction along all time intervals in comparison to its non pregnant value. At the mid and late periods, significant reductions in nitric oxide (NO) levels were observed relative to the non pregnant values. Using Pearson correlation, ADA correlated positively with TP, globulin (GLOB) and GGT, and negatively with TB. In conclusion, the pregnancy in Saidi ewes is marked with biphasic modulation in ADA, impairment in liver functionality and adaptation in the face of oxidative stress at least on the level of lipid peroxidation. In addition, monitoring of the biochemical measurements in the blood of ewes in the different stages of pregnancy gives the basis for carrying out the treatment more effectively, and implementation of preventive measures against the metabolic disorders of ewes in order to reduce the economic losses.

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Section: Discussionmentioning

confidence: 99%

Assessment of Adenosine Deaminase (Ada) Level in Pregnant Ewes in Relation to Liver Function Test and Some Oxidant Indicator

Abou-Khali

2017

Assiut Veterinary Medical Journal

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“…Because our rabbits were mated at 16-18 wk of age, the expected decline in cholesterol levels that occurs during the first 12-13 wk of life cannot account for this change (14), nor is impaired secretion considered to be a likely cause (54). Possible mechanisms for the difference in the magnitude of the change in pregnant rabbits include increased storage of cholesterol in tissues, transfer of maternal cholesterol to the litter, increased excretion in the feces (31), or increased thyroid activity (51,57).…”

Section: Discussionmentioning

confidence: 99%

“…But others reported that triglycerides progressively increased throughout pregnancy and that cholesterol concentrations fell during the first 8-12 wk of gestation and then rose linearly until parturition (3,35). Increased cholesterol levels are thought to reflect increased production of sex steroids (9,52), whereas increased triglycerides may relate to the nutritional requirements of the mother and fetus (9,52 (31), or increased thyroid activity (51,57). Cholesterol levels are known to be inversely related to thyroid function (26), although in pregnant women, increased cholesterol levels and increased thyroid function have been reported to occur (7).…”

Section: Methodsmentioning

confidence: 99%

Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

et al. 1999

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Hematology and serum chemistry parameters were analyzed in 2 groups of pregnant rabbits to assess changes in these parameters over the course of gestation. These data were used to generate a historical control reference range for embryofetal development regulatory toxicology studies. During the 28-day gestation period, the following major changes were observed. Red blood cell counts, hemoglobin, and hematocrit increased slightly up to day 13

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Development of the response of rabbit fetal tissues to thyroxine

Salakhova¹,

Mirmakhmudova²,

Gainutdinov³

et al. 1978

Bull Exp Biol Med

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State of the pituitary-thyroid system in pregnant rabbits, fetuses, and newborn rabbits

Cited by 3 publications

References 1 publication

Assessment of Adenosine Deaminase (Ada) Level in Pregnant Ewes in Relation to Liver Function Test and Some Oxidant Indicator

Assessment of Adenosine Deaminase (Ada) Level in Pregnant Ewes in Relation to Liver Function Test and Some Oxidant Indicator

Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

Development of the response of rabbit fetal tissues to thyroxine

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