Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

Wells, Monique Y.; Decobecq, Catherine P.-M.; Decouvelaere, Danièle M.; Justice, Corinne; Guittin, Pierre

doi:10.1177/019262339902700315

Cited by 48 publications

(68 citation statements)

References 50 publications

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“…RBC, Hb and Ht decreased on Days 7, 14, 17 and 21 compared with non-pregnant rats, and the degree of decrease correlated with the course of pregnancy. These changes were consistent with the results of previous studies on pregnant rats (LaBorde et al, 1999;Papworth and Clubb, 1995;De Rijk et al, 2002;Kim et al, 2000;Katoh et al, 1992), rabbits (Wells et al, 1999), and womanemia, can be attributed to the normal plasma volume increase termed as hemodilution that occurs during pregnancy (Papworth and Clubb, 1995;De Rijk et al, 2002;Kim et al, 2000;Katoh et al, 1992;Baylis, 1980) and Table 1 to a decrease in the lifespan of erythrocytes (Lurie and Danon, 1992). Reticulocyte increased on Days 7, 14 and 17; this change might be a compensatory response to anemia; however, it was on the same level as that of non-pregnant -ciency anemia was induced in pregnant rats at the end of pregnancy, similar to pregnant women (Haram et al, 2001).…”

Section: Resultssupporting

confidence: 93%

Time-course changes of hematology and clinical chemistry values in pregnant rats

Honda¹,

Honda²,

Kokubun³

et al. 2008

J. Toxicol. Sci.

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Section: Resultssupporting

confidence: 93%

Time-course changes of hematology and clinical chemistry values in pregnant rats

Honda¹,

Honda²,

Kokubun³

et al. 2008

J. Toxicol. Sci.

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“…A variety of factors can affect the haematological and biochemical parameters of an animal, including breed, gender, diet, age, reproductive status and seasonal variations (Wells et al, 1999;Ozegbe, 2001). The haematological and biochemical parameters obtained in this study were within the normal ranges for rabbit species (Archetti et al, 2008;Özkan et al, 2012).…”

Section: Haematological Findingssupporting

confidence: 65%

“…On the other hand, Wells et al (1999) reported a decrease in TP and albumin in pregnant rabbits, and this is thought to reflect an increased blood volume.…”

Section: Haematological Findingsmentioning

confidence: 98%

Rabbit dietary supplementation with pale purple coneflower. 1. Effects on the reproductive performance and immune parameters of does

Dabbou

Rotolo

Kovitvadhi

et al. 2016

Animal

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Echinacea pallida (EPAL), also known as pale purple coneflower, is a herbaceous flowering plant with immune-enhancement and antioxidative properties. The effect of EPAL on the reproductive performance, serum biochemistry and haematological parameters of rabbit does has been studied here. A total of 100, 21-week-old Grimaud rabbit does, were randomly assigned to two groups. One group was fed a basal diet supplemented with 3 g EPAL/kg diet (Echinacea group, E), while the other was fed the basal diet without the supplementation (control group, C). The reproductive performance of the does was not affected by the treatment ( P > 0.05). The haematological parameters of pregnant rabbits showed that there was no interaction between gestation day and treatment. The EPAL supplementation induced a reduction (−47.3%) in the basophil cell rate (0.55% and 0.29%, for the control and treatment groups, respectively; P = 0.049). The gestation day significantly affected most of the haematological parameters ( P < 0.05). The white blood cell counts declined progressively after day 14. The mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, red cell distribution width, mean platelet volume and eosinophils increased steadily throughout the study, and reached a maximum value on day 28. The red blood cells, haemoglobin, haematocrit, mean corpuscular volume and neutrophils increased slightly up to day 14, and then subsequently decreased progressively until day 28. The lymphocytes and platelet distribution width decreased until day 14, and then increased to a maximum value on day 28. No significant effect of gestation day or treatment was observed on the blood serum chemistry. As far as the immune parameters are concerned, no significant differences were observed between groups, while a significant effect of gestation day was observed for lysozymes (6.02 v. 7.99 v. 1.91; for 0, 14 and 28 days, respectively; P = 0.014). In conclusion, a lack of effect of EPAL has been observed. In fact, no impacts of EPAL have been observed on the reproductive or haematological parameters of the does. The effects of dietary supplementation with EPAL on the performances, bacterial community, blood parameters and immunity in growing rabbits are reported in the second part of this study.

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“…Plasma triglycerides (TG) decreased at D 22 then increased at D 30 and even more after parturition. For Wells et al (1999), this parameter measured in the plasma of New Zealand female rabbits increases at D 19 and decreases until D 28 whereas Montoudis et al (1999) demonstrated a reduction in plasma TG content at D 22 followed by an increase at the end of gestation. Cholesterol decreased significantly at the 22 nd day of gestation and it increased in post-partum plasma.…”

Section: Quantification Of Matrix Metalloproteinases Mmp-2 and Mmp-9 mentioning

confidence: 94%

Variations in plasma matrix metalloproteinases and placental pregnancy - associated glycoproteins during gestation in rabbits

Othmani-Mecif¹,

Benazzoug²,

Jacob³

et al. 2010

World rabbit sci.

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Adaptation to pregnancy involves major maternal anatomical, physiological and metabolic modifications to support the mother's metabolic needs and those of the growing foetus. Invasion of embryonic territories and implantation in humans and other mammals is the result of an active biochemical process. The invasive faculty of cytotrophoblastic cells depends on their capacity to secrete proteolytic enzymes such as matrix metalloproteinases (MMPs). Many studies have addressed the variations in MMPs in placental tissues, but few have reported on their measurements in plasma. Furthermore, the Pregnancy-Associated Glycoproteins (PAGs), which are synthesized in the syncytiotrophoblast and used as early markers of pregnancy in domestic and wild animals, have not yet been studied in rabbits. In this study, we attempt to purify PAGs from rabbit placenta using a previously described methodology and to measure their concentrations as well as those of MMP-2 and MMP-9 in the plasma throughout pregnancy. In the course of the work, we noted certain modifications of the biochemical parameters in plasma during gestation, essentially in glycemia and lipemia. We detected proteins immunologically-related to PAGs in placental extracts between D 14 to D 21 . Until now, it has been impossible to develop a homologous RIA in order to measure PAGs in rabbit plasma, as the recovery of PAGs during the purification procedure was very low and PAGs were undetectable in rabbit plasma using heterologous RIAs. Finally, we demonstrated a rise in MMP-2 and -9 at the middle and the end of the gestation. However, the small variations presented by these matrix metalloproteinases preclude the use of plasma levels of these enzymes as early markers of pregnancy progress in the rabbit.

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Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

Cited by 48 publications

References 50 publications

Time-course changes of hematology and clinical chemistry values in pregnant rats

Time-course changes of hematology and clinical chemistry values in pregnant rats

Rabbit dietary supplementation with pale purple coneflower. 1. Effects on the reproductive performance and immune parameters of does

Variations in plasma matrix metalloproteinases and placental pregnancy - associated glycoproteins during gestation in rabbits

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