State of the art report on wet granulation technology

Abstract

Granulation technologies are commonly used in the production of granular powders and tablets. The main purpose of this technology is to obtain granules, due to which the pharmaceutical substance dosing uniformity and an increase in tapped density essential during transportation and storage are achieved. In addition, it allows minimizing dust formation, thus increasing the safety of the production process. The article presents the results of a theoretical study of recent advances in wet granulation technology, namely, a brief description of the modifications of this technology, accompanied by schematic illustrations of the key stages of the process, as well as the advantages and limitations. of these modifications. The prerequisite for the emergence of alternative modifications of wet granulation technology was the limitations associated with the instability of pharmaceutical substances and the desire to reduce the time frame of the manufacturing process.