State of the Art of Nanobiotechnology Applications in Neglected Diseases

Marcato, Priscyla D.; Teixeira, Zaine; Durán, Nélson; Costa, Fabio T. M.; Brocchi, Marcelo

doi:10.2174/157341309789378069

Cited by 23 publications

(12 citation statements)

References 119 publications

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“…Drug resistance compromises present treatment options and absence of effective vaccination warrants to search for new compounds with anti-leishmanial activity. Nanotechnology is implied in two different directions: the development of nano-liposomal formulations containing conventional anti-leishmanial drugs, for instance, antimonial and amphotericin B liposomes (Duran et al 2009), and the use of nanoparticles of metals or metal oxides, including AgNPs, Ag 2 O and TiO 2 nanoparticles (Allahverdiyev et al 2011a, b, c).…”

Section: Anti-protozoal Activity Of Silver Nanoparticlesmentioning

confidence: 99%

Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects

Rai

Kon

Ingle

et al. 2014

Appl Microbiol Biotechnol

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397

203

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There are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attention of scientists all over the world. The aim of the present review is to discuss broad-spectrum multifunctional activities of silver nanoparticles and stress their therapeutic potential as smart nanomedicine. Much emphasis has been dedicated to the antimicrobial and anticancer potential of silver nanoparticles showing their promising characteristics for treatment, prophylaxis and control of infections, as well as for diagnosis and treatment of different cancer types.

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Section: Anti-protozoal Activity Of Silver Nanoparticlesmentioning

confidence: 99%

Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects

Rai

Kon

Ingle

et al. 2014

Appl Microbiol Biotechnol

Self Cite

397

203

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show abstract

“…Previous studies have attempted to produce novel AMB pharmaceutical formulations with lower toxicity and cheaper cost. Among these are novel polymeric nanocarriers [5,14] that can improve the stability of active substances. A cluster dextrin was evaluated for AMB encapsulation [15] and, although the system displayed self-aggregation as observed with Fungizone® and AmBiosome®, lower hemolytic activity and a higher retention of AMB in plasma was observed than with Fungizone® [15].…”

Section: Introductionmentioning

confidence: 99%

Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

Sombra¹,

Richter²,

Araújo

et al. 2019

International Journal of Biological Macromolecules

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Stable oil nanocapsules based on acetylated Sterculia striata polysaccharide (ASSP) were produced without the use of a surfactant, and derivatives of ASSP with four different degrees of substitution (DS) were synthesised. The data revealed that only derivatives with high DS were able to produce nanocapsules (NC), which exhibited monomodal size distribution profiles with a Z-average particle size,-potential, and polydispersity index (PDI) that were dependent on ASSP DS and concentration. Nanocapsules were loaded with amphotericin B (AMB) with encapsulation efficiencies (EE%) thatwere dependent on drug and ASSP concentrations and DS. A maximum EE% value of 99.2%was achieved, and the loaded AMBwas found to be in amonomeric form, evenwith a concentration one hundredfold higher than that usually observed for commercial AMB aqueous solutions. Loaded nanocapsules show an in vitro controlled release of AMB. As the monomeric AMB state decreased drug toxicity, ASSP nanocapsules loaded with AMB (NC1.68) have potential for use as a drug delivery system. AMB loaded NC 1.68 keeps its activity against 5 strains of Candida albicans tested.

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“…Biogenic synthesis of Ag°nanoparticles is from a long time known for many researchers, and several excellent reviews were published in the last 6 years (Abbasi et al 2014;Faramarzi and Sadighi, 2013;de Lima et al 2012;Durán et al 2009Durán et al , 2010Durán et al , 2014aIngal and Chaudhari, 2013;Keat et al 2015;Mashwani et al 2015;Mittal et al 2014;Moghaddam et al 2015;Natsuki et al 2015;Rai et al 2009). Biogenic synthetic routes have several advantages over traditional chemical or physical ones, since they are environmentally friendly technology (Seabra and Durán, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments

Durán

Nakazato

Seabra

2016

Appl Microbiol Biotechnol

245

127

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The antimicrobial impact of biogenic-synthesized silver-based nanoparticles has been the focus of increasing interest. As the antimicrobial activity of nanoparticles is highly dependent on their size and surface, the complete and adequate characterization of the nanoparticle is important. This review discusses the characterization and antimicrobial activity of biogenic synthesized silver nanoparticles and silver chloride nanoparticles. By revising the literature, there is confusion in the characterization of these two silver-based nanoparticles, which consequently affects the conclusion regarding to their antimicrobial activities. This review critically analyzes recent publications on the synthesis of biogenic silver nanoparticles and silver chloride nanoparticles by attempting to correlate the characterization of the nanoparticles with their antimicrobial activity. It was difficult to correlate the size of biogenic nanoparticles with their antimicrobial activity, since different techniques are employed for the characterization. Biogenic synthesized silver-based nanoparticles are not completely characterized, particularly the nature of capped proteins covering the nanomaterials. Moreover, the antimicrobial activity of theses nanoparticles is assayed by using different protocols and strains, which difficult the comparison among the published papers. It is important to select some bacteria as standards, by following international foundations (Pharmaceutical Microbiology Manual) and use the minimal inhibitory concentration by broth microdilution assays from Clinical and Laboratory Standards Institute, which is the most common assay used in antibiotic ones. Therefore, we conclude that to have relevant results on antimicrobial effects of biogenic silver-based nanoparticles, it is necessary to have a complete and adequate characterization of these nanostructures, followed by standard methodology in microbiology protocols.

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State of the Art of Nanobiotechnology Applications in Neglected Diseases

Cited by 23 publications

References 119 publications

Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects

Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects

Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments

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