State-of-the-art approach in selective curable tumors: bone sarcoma

Bielack, Stefan; Carrle, Dorothe

doi:10.1093/annonc/mdn436

Cited by 25 publications

(18 citation statements)

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“…Osteosarcoma is the most common primary bone tumor in dogs and humans (1)(2)(3) and is characterized by both aggressive local tissue infiltration and a very high metastatic rate. Despite the use of neoadjuvant and adjuvant chemotherapy, the 5-year survival rate is only 60% in humans and the 2-year survival rate is only 20% in dogs, illustrating that new therapeutics are needed (1).…”

Section: Introductionmentioning

confidence: 99%

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Expression and Function of Survivin in Canine Osteosarcoma

et al. 2012

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Osteosarcoma has a high mortality rate and remains in need of more effective therapeutic approaches. Survivin is an inhibitor of apoptosis family member protein that blocks apoptosis and drives proliferation in human cancer cells where it is commonly elevated. In this study, we illustrate the superiority of a canine osteosarcoma model as a translational tool for evaluating survivin-directed therapies, owing to the striking similarities in gross and microscopic appearance, biologic behavior, gene expression, and signaling pathway alterations. Elevated survivin expression in primary canine osteosarcoma tissue correlated with increased histologic grade and mitotic index and a decreased disease-free interval (DFI). Survivin attenuation in canine osteosarcoma cells inhibited cell-cycle progression, increased apoptosis, mitotic arrest, and chemosensitivity, and cooperated with chemotherapy to significantly improve in vivo tumor control. Our findings illustrate the utility of a canine system to more accurately model human osteosarcoma and strongly suggest that survivin-directed therapies might be highly effective in its treatment. Cancer Res; 72(1); 249-59. Ó2011 AACR.

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Section: Introductionmentioning

confidence: 99%

“…Despite the use of neoadjuvant and adjuvant chemotherapy, the 5-year survival rate is only 60% in humans and the 2-year survival rate is only 20% in dogs, illustrating that new therapeutics are needed (1).…”

Section: Introductionmentioning

confidence: 99%

Expression and Function of Survivin in Canine Osteosarcoma

et al. 2012

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“…The shortest distance to the lesion is not necessarily the optimal route. 3,4,[10][11][12][13][14][15][16] The biopsy tract should be carefully planned according to the site of the definitive surgery so that it will be included and removed en bloc with the resection specimen to avoid local recurrence. The biopsy tract should be considered contaminated with tumor, must not tra-n guest editorial verse more than 1 anatomical compartment, and should be away from neurovascular bundles.…”

Section: The Radiologist's Perspectivementioning

confidence: 99%

“…Additional appropriate biopsy specimens can be taken from suspicious sites, as the exact staging of the disease has an impact on treatment and outcome. 5,[10][11][12][13][14][15][16] If an infection is suspected, antibiotics should be discontinued at least 48 hours, ideally 2 to 3 weeks, before biopsy, and tissue samples should also be sent for microbiological culture. The accuracy of percutaneous disk biopsy for suspected spondylodiscitis is less than 47%; in this setting, both disk and adjacent subchondral bone should be included in the specimen.…”

Section: The Radiologist's Perspectivementioning

confidence: 99%

“…Adequate samples of representative areas must be obtained for histology. 5,[10][11][12][13][14][15][16] For intraosseous bone lesions, the optimal shape of the cortical window to avoid a pathological fracture should be oblong with rounded ends. 16 Open biopsy can be combined with frozen-section histological analysis to ensure that diagnostic material has been obtained, and if the diagnosis of a benign lesion is made, complete curettage of the tumor can be performed.…”

Section: A B N Guest Editorialmentioning

confidence: 99%

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How Should Musculoskeletal Biopsies Be Performed?

Mavrogenis¹,

Angelini²,

Errani³

et al. 2014

Orthopedics

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Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells

et al. 2013

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Antitumor effects of hybrid liposomes (HL) composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether (C12(EO)23) on the metastatic growth of murine osteosarcoma (LM8) cells were investigated in vitro and in vivo. Remarkable inhibitory effects of HL-23 on the growth of LM8 cells were obtained through the induction of apoptotic cell death in vitro. It was also indicated that HL-23 should dramatically suppress the invasion of LM8 cells and the formation of filopodia on the cell surface in vitro. Furthermore, significantly high therapeutic effects were observed in the homograft mouse models of LM8 cells with lung metastasis after the treatment with HL-23 in vivo. That is, the histological analysis demonstrated that the primary tumor growth of LM8 cells implanted subcutaneously into the mice was inhibited along with the induction of apoptosis. In addition, it was found that HL-23 significantly decreased the lung metastasis of LM8 cells in the mouse models through the inhibition of primary tumor invasion. These results suggest that HL-23 could be a novel agent for the chemotherapy of osteosarcoma.

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State-of-the-art approach in selective curable tumors: bone sarcoma

Cited by 25 publications

References 0 publications

Expression and Function of Survivin in Canine Osteosarcoma

Expression and Function of Survivin in Canine Osteosarcoma

How Should Musculoskeletal Biopsies Be Performed?

Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells

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