“…The benefits of using a phospholipid bilayer nanoconstruct, as shown in Figures 1 (A), 1 (B), and 1 (C), include dual loading of hydrophilic and hydrophobic drugs, improved bioavailability to target site cell and tissue, stability of encapsulated drugs, pharmacological inactivity and minimal toxicity of phospholipids [29,40]. Several investigations have shown the benefits of encapsulating curcumin in different cancer types such as pancreatic adenocarcinoma, osteosarcoma, liver cancer etc [41][42][43][44]. Different types of lipid based nanosystems, such as long circulating PEGylated, cationic liposomes and so on, have shown promise due to the flexibility of altering its properties by changing the composition and concentration of lipids [41,45,46].…”