State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

Mukhina, A. Yu.; Медведева, О. А.; Svishcheva, M. V.; Shevchenko, A. V.; Efremova, N. N.; Bobyntsev, I. I.; Калуцкий, П. В.; Andreeva, L. A.; Myasoedov, N. F.

doi:10.1007/s10517-019-04496-y

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…Также эффекты тафтцина-ПГП на состояние функций нервной системы могут реализовываться через изменение под его действием состава микробиоты толстой кишки и снижение выраженности стресс индуцированных морфологических изменений в ней [7,9].…”

Section: × * *unclassified

“…Показано, что тафтцин-ПГП оказывал стресслимитирующее действие в условиях хронического иммобилизационного стресса: приводил к нормализации состава кишечной микробиоты, снижению вызванных стрессом воспалительных изменений стенки толстой кишки [7,9,13]. При этом стоит отметить, что в данных исследованиях пептид начинали вводить животным одновременно с началом стрессового воздействия, что можно рассматривать как первый этап определения эффектов тафтцина-ПГП в условиях стресса.…”

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State of nervous system functions of Wistar rats when using peptide taftsin-PGP (selank) in restraint stress

Bobyntsev,

Krivoshlykova,

Medvedeva

et al. 2023

Humans and their Health

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The aim of the study was to investigate the state of functions of the nervous system of Wistar rats upon application of the peptide taftsin-PGP under conditions of chronic stress. Materials and methods. The experiments were performed on 45 male Wistar rats weighing 200-230 g. Selank peptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was injected intraperitoneally at doses of 80, 250 and 750 μg/kg 15 min before stressor exposure. Animals were divided into 5 groups (n = 9): 1 - control (non-stressed animals injected with saline); 2 - stress (stressed animals injected with saline); 3-5 - stress+taftsin-PGP at doses of 80, 250 and 750 µg/kg. Animals were stressed for 28 days; from days 15 to 28, they were injected with selank/saline. The neurotropic effects of selank were evaluated in the elevated plus-maze, open field (OF) and forced swimming tests. To assess the severity of stress response, the concentration of corticosterone in rat serum was evaluated using enzyme immunoassay. Results. It was found that 28-day immobilisation stress caused disturbances of nervous system functions in the form of increased anxiety, horizontal, vertical, locomotor activity, emotionality and expression of depressive behaviour, as well as increased concentration of corticosterone in blood serum of experimental animals. Taftsin-PGP administration against the background of preliminary stressing (from the 15th to the 28th day of the experiment) contributed to a decrease in the severity of stress-induced behavioural changes in rats: at a dose of 750 µg/kg the peptide had anxiolytic effect, 250 µg/kg - antidepressant effect. At the same time, these changes occurred against the background of a significant decrease in serum corticosterone level. Conclusion. Thus, selank corrects stress-induced changes in the state of nervous system functions under 28-day restraint stress.

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State of nervous system functions of Wistar rats when using peptide taftsin-PGP (selank) in restraint stress

Bobyntsev,

Krivoshlykova,

Medvedeva

et al. 2023

Humans and their Health

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“…Alterations in the gut microbiome during psychological stress have been reported previously [8] , [37] . In brief, most animal studies using the chronic stress model showed a significant reduction in bacteria, such as Lactobacillus and Bifidobacterium, at the genus level under different stress conditions [8] , [38] , [39] . Lactobacillus and Bifidobacterium, used as probiotics, have been shown to be effective in improving mental health in humans [40] .…”

Section: Psychological Stress and Gut Microbesmentioning

confidence: 99%

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Paudel

Uehara²,

Giri³

et al. 2022

Japanese Dental Science Review

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“…При этом изменение качественного и количественного состава микробиоты может наблюдаться даже после кратковременного стрессорного воздействия [102]. Ранее нами было показано, что хронический иммобилизационный стресс приводил к изменению состава микробиоты толстой кишки в виде уменьшения количества облигатных микроорганизмов и увеличения условно-патогенных [103][104][105][106], которое было ассоциировано с воспалительными изменениями в стенке толстой кишки [107][108][109]. При этом ежедневное внутрибрюшинное введение тафтцина-ПГП и N-синтетического аналога АКТГ, АКТГ4-7-ПГП корригировало стресс-индуцированные изменения как в микробиоте толстой кишки, так и в ее стенке [104,108,109].…”

Section: влияние метаболических факторов микробиоты на морфофункцио-н...unclassified

On mechanisms of increased intestinal wall permeability under stress

Vorvul¹,

Bobyntsev²,

Медведева³

2022

Humans and their Health

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One of the manifestations of the stress reaction in the colon is an increase in the permeability of its wall due to the development of an inflammatory reaction against the background of changes in neuroendocrine regulation and microbiota state. These processes are accompanied by significant changes in humoral homeostasis and cell activity involved in the development of an inflammatory response in the colon wall. We performed a literature review to analyze and summarize the available research data on the mechanisms of stress-induced changes in the intestine at the molecular, cellular and tissue levels involving the regulatory systems of the body. Scientific information was searched in Web Of Science, Scopus, ScienceDirect, Medline, Russian Science Citation Index (RSCI), as well as in the search engines Google Scholar, PubMed, Semantic Scholar, Taylor & Francis, Wiley Online Library and Bielefeld Academic Search Engine (BASE). Wall permeability has been shown to have a rather complex regulation involving corticotropin-releasing factor, mast cells, dendritic cells, eosinophils, macrophages, Substance P, nerve growth factor, neurotensin, microbiota metabolic factors (serotonin, short-chain fatty acids, indole derivatives and conjugated fatty acids), epigenetic mechanisms, the HES1 (Hairy/Enhancer of Split-1) - GR (glucocorticoid receptor), and the stress-associated polarity signaling pathway. Under stress, there is a change in the functioning of these mechanisms, leading to an increase in the permeability of the intestinal wall. It results in translocation of bacteria from the lumen into the underlying layers which causes activation of the immune response with subsequent development of an inflammatory reaction. The presented data testify to the prospects and validity of the development of methods of correction of stress-induced shifts in the colon by influencing the central and local mechanisms of realization of the stress response and the state of the microbiota.

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State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

Cited by 7 publications

References 4 publications

State of nervous system functions of Wistar rats when using peptide taftsin-PGP (selank) in restraint stress

State of nervous system functions of Wistar rats when using peptide taftsin-PGP (selank) in restraint stress

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

On mechanisms of increased intestinal wall permeability under stress

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