Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Paudel, Durga; Uehara, Osamu; Giri, Sarita; Yoshida, Koki; Morikawa, Tetsuro; Kitagawa, Takao; Matsuoka, Hirofumi; Miura, Hiroko; Toyofuku, Akira; Kuramitsu, Yasuhiro; Ohta, Takeshi; Kobayashi, Masanobu; Abiko, Yoshihiro

doi:10.1016/j.jdsr.2022.11.003

Cited by 14 publications

(11 citation statements)

References 102 publications

(177 reference statements)

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“…Firstly, mental issues like depression and anxiety may lead to increased release of stress hormones such as ACTH, catecholamines, and cortisol. The changes in these hormones may directly or indirectly affect the gut microbiota ecosystem through their impact on the gut environment [10]. Most of these hormones can enter the gut through circulation, and some of these hormones like CRF and cortisol can be produced in smaller amounts by the gut enteric neurons, enterochromaffin cells, and epithelial cells.…”

Section: Stress Hormonsmentioning

confidence: 99%

“…Most of these hormones can enter the gut through circulation, and some of these hormones like CRF and cortisol can be produced in smaller amounts by the gut enteric neurons, enterochromaffin cells, and epithelial cells. According to studies, the direct interaction of cortisol with gut microbiota negatively impacts the alpha and beta diversity inside intestines [10]. ACTH, catecholamines, and cortisol can increase the adherence of bacterial to the mucosa on the gut.…”

Section: Stress Hormonsmentioning

confidence: 99%

“…Alteration of serotonin levels can be observed in multiple psychiatric disorders [12]. This may lead to excessive or insufficient generation of certain products [10]. Although the specific mechanism of how serotonin and gut microbiota affect each other is still unclear, the connection of some neurotransmitters and the gut microbiota can still be suggested [12].…”

Section: Neurotransmittersmentioning

confidence: 99%

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Research Progress: Relationship Between Gut Microbiome and Mental Health

Yao

2024

HSET

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The relationship between the gut microbiome and mental health has received much attention recently. Recent studies have demonstrated a dual crosstalk relationship within the gut-brain axis (GBA), but some specific mechanisms of their relationship still need to be further explored. Based on recent GBA-related research, this article summarizes and analyzes the intricate connections within GBA and analyzes the potential of probiotic treatment for mental health (especially depression and anxiety). Through analysis, this paper found that a variety of indicators can be used to monitor the effectiveness of treatment processes, including questionnaires and DNA sequencing of stool samples. The clinical application of probiotics can also help relieve symptoms such as anxiety and insomnia, providing patients with a relatively safe treatment option. The conclusions of this article help to provide a reference for the research progress related to GBA and provide new ideas for further exploring the intrinsic mechanism of GBA.

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Section: Stress Hormonsmentioning

confidence: 99%

Section: Stress Hormonsmentioning

confidence: 99%

Section: Neurotransmittersmentioning

confidence: 99%

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Research Progress: Relationship Between Gut Microbiome and Mental Health

Yao

2024

HSET

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“…From Paudel et al's review on the effect of psychological stress on oral-gut microbiota, it appears that noradrenaline decreases the growth of P. gingivalis and A. actinomycetemcomitans and promotes the growth of Actinomyces naeslundii, Actinomyces gerenscseriae, Eikenella corrodens and Campylobacter gracilis (2022). Moreover, noradrenaline reduces the production of an auto-inducer while increasing the expression of genes of a major virulence factor of P. gingivalis called protease arg-gingipainB [9].…”

Section: Effect On Microbiomementioning

confidence: 99%

Gingival Disease as a Symptom of Stress

Tsobgny Nadia-Flore

2024

Dentistry

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Stress has become the health epidemic of the twenty-first century; its burden we faced is due to social and professional pressure (spouse death, marital separation and loss of job). If stress is supposed to help an organism to go through daily issue and particular emotional issues, it can be a source of health damage, when sustained. Negative effects of stress can go from change in life style to cardiovascular events and cognitive disorders. Periodontal health can also be affected. During chronic stress, T helper 2 (Th2) lymphocytes are responsible for promoting the destruction of periodontal tissue. Wrong stress management is characterized by changes in life style like poor oral hygiene, smoking, diet modification and parafunctions. This contributes to increase dental biofilm and worsen periodontitis. The most clinically relevant effects are wound healing and response to periodontal treatment. Suppression of immune response components during stress prevents the elimination of damaged tissues as well as any new tissue buildup. Moreover, peripheral vasoconstriction and low oxygen resulting from excessive catecholamine during stress compromise wound healing and response to periodontal treatment. This highlights the importance of knowledge about psychological state of patients with periodontitis and the need for coping strategies’ improvement in an emotionally stressed patient to expect good response to treatment.

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“…Porphyromonas gingivalis has the ability to affect the complement system mechanism, which can lead to microbiota dysbiosis [ 33 ]. Porphyromonas gingivalis induces the expression of phospholipase A2-IIA (PLA2-IIA) in oral epithelial cells, which is related to microbiota dysbiosis in the mouth [ 34 ]. The gut and oral microbiome can be altered by psychological stress.…”

Section: Factors Contributing To Microbiota Dysbiosismentioning

confidence: 99%

Insights into Microbiota in Sjögren’s Syndrome

Mieliauskaitė,

Kontenis

2023

Medicina

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Primary Sjögren’s syndrome (pSS) is a heterogeneous chronic autoimmune disorder with multiple clinical manifestations that can develop into non-Hodgkin’s lymphoma in mucosa-associated lymphoid tissue. The pathogenesis of Sjögren’s syndrome (SS) is not completely understood, but it is assumed that pathogenesis of SS is multifactorial. The microbiota plays a notable role in the development of autoimmune disorders, including Sjögren’s syndrome. Molecular mimicry, metabolite changes and epithelial tolerance breakdown are pathways that might help to clarify the potential contribution of the microbiota to SS pathogenesis. This review aims to provide an overview of recent studies describing microbiota changes and microbiota mechanisms associated with Sjögren’s syndrome. Data on the microbiota in SS from PubMed, Web of Science, Scopus and the Cochrane Library databases are summarized. Overall, the microbiota makes a major contribution to the development of Sjögren’s syndrome and progression. Future microbiota studies should improve the management of this heterogeneous autoimmune disease.

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Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Cited by 14 publications

References 102 publications

Research Progress: Relationship Between Gut Microbiome and Mental Health

Research Progress: Relationship Between Gut Microbiome and Mental Health

Gingival Disease as a Symptom of Stress

Insights into Microbiota in Sjögren’s Syndrome

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