State-independent and -dependent structural alterations in limbic-cortical regions in patients with current and remitted depression

Guo, Xiong; Dong, Daifeng; Cheng, Chang; Jiang, Yali; Sun, Xiaoqiang; He, Jiayue; Li, Chuting; Gao, Yidian; Zhong, Xue; Zhao, Hanqing; Wang, Xiang; Yao, Shuqiao

doi:10.1016/j.jad.2019.07.065

Cited by 27 publications

(24 citation statements)

References 94 publications

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“…Moreover, the integrity and coordinated function of medial PFC indeed plays an important role in the cognitive function of attention ( 75 ). A previous study reported that the dorsolateral prefrontal cortex (including the caudal MFC), supplementary motor area, and posterior cingulate cortex participated in the dorsal attention network, which would be active during attention-demanding tasks ( 76 ). Therefore, though narrowly escaping statistical significance, the decreased GMV in the right MFC may be crucial for the attention/vigilance function in MDD patients.…”

Section: Discussionmentioning

confidence: 99%

Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study

Zhang

Xiao

et al. 2021

Front. Psychiatry

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Objective: Numerous studies indicate that schizophrenia (SCZ) and major depressive disorder (MDD) share pathophysiological characteristics. Investigating the neurobiological features of psychiatric-affective disorders may facilitate the diagnosis of psychiatric disorders. Hence, we aimed to explore whether patients with SCZ and patients with MDD had the similar or distinct cognitive impairments and GMV alterations to further understand their underlying pathophysiological mechanisms.Methods: We recruited a total of 52 MDD patients, 64 SCZ patients, and 65 healthy controls (HCs). The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery was used to assess cognitive functions. In addition, voxel-based morphometry (VBM) analysis was used to evaluate the gray matter volume (GMV) by using MRI scanning. One-way ANOVA and post-hoc tests were used to find the differences among the MDD, SCZ, and HCs. Finally, we explored the correlation between structural alterations and cognitive functions.Results: Compared with that of HCs, processing speed was impaired in both patients with SCZ and patients with MDD (F = 49.505, p < 0.001). SCZ patients displayed impaired cognitive performance in all dimensions of cognitive functions compared with HCs (p < 0.001, except social cognition, p = 0.043, Bonferroni corrected). Whole-brain VBM analysis showed that both SCZ and MDD groups had reductions of GMV in the medial superior frontal cortex (cluster-level FWE p < 0.05). Patients with SCZ exhibited declining GMV in the anterior cingulate cortex and right middle frontal cortex (MFC) compared with HCs and MDD patients (cluster-level FWE p < 0.05). The mean values of GMV in the right MFC had a positive correlation with the attention/vigilance function in patients with MDD (p = 0.014, partial. r = 0.349, without Bonferroni correction).Conclusions: In total, our study found that MDD and SCZ groups had common cognitive impairments and brain structural alterations, but the SCZ group exhibited more severe impairment than the MDD group in both fields. The above findings may provide a potential support for recognizing the convergent and divergent brain neural pathophysiological mechanisms between MDD and SCZ.

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Section: Discussionmentioning

confidence: 99%

Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study

Zhang

Xiao

et al. 2021

Front. Psychiatry

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“…A recent SBM study revealed that patients with current episodes of MDD showed increased SA in the left precuneus and right pericalcarine gyrus compared to remitted MDD. 55 Moreover, one twin study demonstrated widespread SA reduction in an occipitotemporal cluster in subjects with high anxiety-depression score. 18 Our finding is partly supported by previous research that showed larger SA in the left lateral occipital cortex and postcentral area in MDD patients with a history of suicide attempt(s) compared to non-attempters.…”

Section: Surface Areamentioning

confidence: 99%

“…Biophysical limitations during SA alteration can cause network disruption. 55,76 The SOG is functionally connected to other regions of the occipital lobe and PCC, comprising the lateral vi-sual cortical network. 50,77,78 The adjacent L-MOG has shown decreased activity in several MDD studies, [79][80][81] and left inferior longitudinal fasciculus, a white matter tract that connects the SOG to the limbic system, 50,82 showed disrupted integrity in drug-naïve MDD.…”

Section: Surface Areamentioning

confidence: 99%

Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness

Lee

Kang

et al. 2021

Psychiatry Investig

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Objective Advances in surface-based morphometric methods have allowed researchers to separate cortical volume into cortical thickness (CTh) and surface area (SA). Although CTh alterations in major depressive disorder (MDD) have been observed in numerous studies, few studies have described significant SA alterations. Our study aimed to measure patients’ SAs and to compare it with their CTh to examine whether SA exhibits alteration patterns that differ from those of CTh in drug-naïve patients with MDD.Methods A total of 71 drug-naïve MDD patients and 111 healthy controls underwent structural magnetic resonance imaging, and SA and CTh were analyzed between the groups.Results We found a smaller SA in the left superior occipital gyrus (L-SOG) in drug-naïve patients with MDD. In the CTh analysis, the bilateral fusiform gyrus, left middle occipital gyrus, left temporal superior gyrus, and right posterior cingulate showed thinner cortices in patients with MDD, while the CTh of the bilateral SOG, right straight gyrus, right posterior cingulate, and left lingual gyrus were increased.Conclusion Compared with the bilateral occipito-temporal changes in CTh, SA alterations in patients with MDD were confined to the L-SOG. These findings may improve our understanding of the neurobiological mechanisms of SA alteration in relation to MDD.

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“…Recent research evidence shows that occipital cortex folding in patients with depression is abnormally increased, and it is highly positively correlated with the course and the severity of the disease, suggesting that occipital dysplasia may be a predictor of the course of depression ( Schmitgen et al, 2019 ). In addition, functional magnetic resonance imaging (fMRI) and PET studies have found reduced occipital blood perfusion in patients with depression ( Oda et al, 2003 ; Brockmann et al, 2009 ; Nagafusa et al, 2012 ; Qiu et al, 2014 ) and thickening of the occipital cortex ( Ge et al, 2019 ) and high gray matter volume ( Rubin-Falcone et al, 2018 ) in patients with first-episode, medication-naive depression. Voxel-based morphometric analysis has shown reduced occipital cortex volumes ( Peng et al, 2016 ; Zhang H. et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Improved Pre-attentive Processing With Occipital rTMS Treatment in Major Depressive Disorder Patients Revealed by MMN

Guan

Liu

Guo

et al. 2021

Front. Hum. Neurosci.

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ObjectivesTo investigate the improvement effect of occipital repetitive transcranial magnetic stimulation (rTMS) combined with escitalopram oxalate tablets on pre-attentive processing in patients with first-episode, medication-naive depression.MethodsPatients who were hospitalized between January and December 2019 were selected. They were randomly allocated to real occipital rTMS stimulation group with 27 cases receiving intermittent theta-burst (iTBS) and sham stimulation group with 24 cases over 20 days. The rTMS treatment target is located at the Oz point of the occipital region. Both groups took escitalopram oxalate tablets, and the average daily drug dose was 15.294 ± 5.041 mg. Hamilton Depression Rating Scale (HAMD) was used to assess the symptoms of depression before and after treatment, and mismatch negativity (MMN) was used to assess the improvement of pre-attentive processing before and after treatment.ResultsAfter 20 days of treatment, the total score of HAMD (13.495 ± 3.700) in both groups was significantly lower than that before treatment [21.910 ± 3.841, F(1, 49) = 46, 3.690, p < 0.001]. After treatment, the latency of MMN in the real stimulation group (182.204 ± 31.878 ms) was significantly lower than that in the sham stimulation group (219.896 ± 42.634 ms, p < 0.001), and the amplitude of MMN in the real stimulation group (−7.107 ± 3.374 ms) was significantly higher than that in the sham stimulation group (−2.773 ± 3.7 32 ms, p < 0.001).ConclusionOccipital rTMS treatment can enhance the early therapeutic effect and effectively improve the pre-attentive processing of patients with depression and provide a scientific basis for the new target of rTMS therapy in clinical patients with depression.

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State-independent and -dependent structural alterations in limbic-cortical regions in patients with current and remitted depression

Cited by 27 publications

References 94 publications

Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study

Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study

Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness

Improved Pre-attentive Processing With Occipital rTMS Treatment in Major Depressive Disorder Patients Revealed by MMN

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