Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study

Ma, Mengying; Zhang, Yuyanan; Xiao, Zeping; Yan, Hao; Zhang, Dai; Yue, Weihua

doi:10.3389/fpsyt.2021.705998

Cited by 8 publications

(4 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it is not surprising that cognitive impairments are a common endophenotype in both illnesses, and the results of the present study lend support to this conclusion. A previous study reported similar cognitive abnormalities in relation to information processing speed and similar reductions in the gray matter volume in the right medial superior frontal cortex associated with executive functions between patients with schizophrenia and major depressive disorder [81]. These results could be consistent with our finding of the absence of any difference in the subjective difficulty with Planning/Organization as assessed by the PDQ, which is thought to reflect executive functions, between patients with schizophrenia spectrum disorders and major depressive disorder in the present study.…”

Section: Discussionsupporting

confidence: 53%

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders

Uchino

Okubo

Takubo

et al. 2023

JPM

View full text Add to dashboard Cite

Background: In schizophrenia spectrum disorders (SSD), social cognition mediates the relationship between neurocognition and social functioning. Although people with major depressive disorder (MDD) also exhibit cognitive impairments, which are often prolonged, little is known about the role of social cognition in MDD. Methods: Using data obtained through an internet survey, 210 patients with SSD or MDD were selected using propensity score matching based on their demographics and illness duration. Social cognition, neurocognition, and social functioning were evaluated using the Self-Assessment of Social Cognition Impairments, Perceived Deficits Questionnaire, and Social Functioning Scale, respectively. The mediation effects of social cognition on the relationship between neurocognition and social functioning were examined in each group. Invariances of the mediation model across the two groups were then analyzed. Results: The SSD and MDD groups had mean ages of 44.49 and 45.35 years, contained 42.0% and 42.8% women, and had mean illness durations of 10.76 and 10.45 years, respectively. In both groups, social cognition had significant mediation effects. Configural, measurement, and structural invariances across the groups were established. Conclusion: The role of social cognition in patients with MDD was similar to that in SSD. Social cognition could be a common endophenotype for various psychiatric disorders.

show abstract

Section: Discussionsupporting

confidence: 53%

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders

Uchino

Okubo

Takubo

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

“…Not only do schizophrenia and major depressive disorder share common symptoms, they also reportedly share a common genetic background [61][62][63]. Therefore, it is not surprising that cognitive impairments are a common endophenotype for both illnesses [64], and the results of the present study support this conclusion. This commonality may be applicable not only to major depressive disorder and schizophrenia, but also to various other mental illnesses.…”

Section: Discussionsupporting

confidence: 78%

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia

Uchino¹,

Okubo²,

Takubo³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: In schizophrenia (SZ), social cognition mediates the relationship between neurocognition and social functioning. Although people with major depressive disorder (MDD) also exhibit cognitive impairments, which are often prolonged, little is known about the role of social cognition in MDD. Methods: Using data obtained through an internet survey, 210 patients with SZ or MDD were selected using propensity score matching based on their demographic information and illness duration. Social cognition, neurocognition, and social functioning were evaluated using the Self-Assessment of Social Cognition Impairments, Perceived Deficits Questionnaire, and Social Functioning Scale, respectively. The mediation effects of social cognition on the relationship between neurocognition and social functioning were examined in each disease group. Invariances of the mediation model across the two groups were then analyzed. Results: The SZ and MDD groups had mean ages of 44.49 and 45.35 years, contained 42.0% and 42.8% women, and had mean illness durations of 10.76 and 10.45 years, respectively. In both groups, social cognition had significant mediation effects. Configural, measurement, and structural invariances across the groups were established. Conclusion: The role of social cognition in patients with chronic depression was similar to that in schizophrenia. Social cognition could be a common endophenotype for various psychiatric disorders.

show abstract

“…Several previous studies have used the MCCB to evaluate the levels of cognition in patients with schizophrenia due to its ideally psychometric properties (27,(66)(67)(68). In the past decades, many studies used MCCB to investigate the relationship between the cognitive performance and brain structural and functional alterations in the patients with schizophrenia (69)(70)(71)(72)(73)(74)(75) (64,66). GDS method can be described briefly as follows: demographically corrected T-scores were converted to deficit scores according to the following criteria: T > 39 = 0 (normal), 39 ≥ T ≥ 35 = 1 (mild impairment), 34 ≥ T ≥ 30 = 2 (mild to moderate impairment), 29 ≥ T ≥ 25 = 3 (moderate impairment), 24 ≥ T ≥ 20 = 4 (moderate to severe impairment), T < 20 = 5 (severe impairment).…”

Section: Participants and Proceduresmentioning

confidence: 99%

Baseline global brain structural and functional alterations at the time of symptom onset can predict subsequent cognitive deterioration in drug-naïve first-episode schizophrenia patients: Evidence from a follow-up study

Zhuo

Chen

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

Alterations in the global brain gray matter volume (gGMV) and global functional connectivity density (gFCD) play a pivotal role in the cognitive impairment and further deterioration in schizophrenia. This study aimed to assess the correlation between alterations in the gGMV and gFCD at baseline (ΔgGMV and ΔgFCD), and the subsequent alterations of cognitive function in schizophrenia patients after 2-year antipsychotic treatment. Global-brain magnetic resonance imaging scans were acquired from 877 drug-naïve, first-episode schizophrenia patients at baseline and after two years of antipsychotic treatment with adequate dosage and duration, and 200 healthy controls. According to ΔgGMV at baseline, schizophrenia patients were divided into mild, moderate, and severe alteration groups. The MATRICS consensus cognitive battery and Global Deficit Score (GDS) were used to assess cognitive impairment. We found that ΔgGMV and ΔgFCD at baseline were significantly correlated with the severity of the cognitive deterioration (ΔGDS). The correlation coefficient indicated a significant positive correlation between baseline ΔgFCD and subsequent cognitive deterioration, with a relatively stronger relation in the mild alteration group (r = 0.31). In addition, there was a significant positive correlation between baseline ΔgGMV and subsequent cognitive deterioration, with a stronger relation in the moderate and severe alteration groups (r = 0.303; r = 0.302, respectively). Our results showed that ΔgGMV and ΔgFCD are correlated with the severity of cognitive deterioration after completion of a 2-year antipsychotic treatment in schizophrenia patients. These findings suggest that baseline alterations in gGMV and gFCD hold potential for predicting subsequent cognitive decline in schizophrenia.

show abstract

Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study

Cited by 8 publications

References 75 publications

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia

Baseline global brain structural and functional alterations at the time of symptom onset can predict subsequent cognitive deterioration in drug-naïve first-episode schizophrenia patients: Evidence from a follow-up study

Contact Info

Product

Resources

About