State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal study

D’Angelo, Cristina; Mirijello, Antonio; Leggio, Lorenzo; Ferrulli, Anna; Carotenuto, Vincenzo; Icolaro, Nadia; Miceli, Antonio; D’Angelo, Vincenzo; Gasbarrini, Giovanni; Addolorato, Giovanni

doi:10.3171/jns/2008/108/2/0281

Cited by 111 publications

(81 citation statements)

References 27 publications

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“…This is in concordance with Goebel et al, who were able to show that patients with meningiomas developed psychological comorbidities similar to patients with high-grade gliomas [17], but in contrast to their findings, supported by results of others [11,23], we found scores to improve in both groups over time with earlier peak BDI scores in patients with extraaxial tumors (3 vs. 6 months) and significant changes over time in patients with intraaxial tumors (p = 0.001).…”

Section: Depression After Surgerysupporting

confidence: 89%

“…has been published to date investigating anxiety and depression in patients with meningiomas after surgical resection [17]. Litofsky et al and D'Angelo et al investigated the course of depressive symptoms and anxiety after glioma surgery [11,23]. Knowing that suicidal ideation (SI) increases in patients with cancer compared to the general population [34,49], especially in cancers associated with physical impairment and dismal prognosis [2,3], one might assume that the incidence of SI in patients with malignant brain tumors is high.…”

Section: Introductionmentioning

confidence: 97%

“…Most common among cancer patients are adjustment disorder, anxiety, and depression [11,38,41]. Over the past years, it has been shown that they can substantially influence patients' prognosis [9,26].…”

Section: Introductionmentioning

confidence: 99%

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Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

et al. 2016

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Section: Depression After Surgerysupporting

confidence: 89%

Section: Introductionmentioning

confidence: 97%

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Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

et al. 2016

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“…Owing to the high integration of the brain structures, it is difficult, and perhaps incorrect, to tailor a psychiatric disorder, or even a psychiatric symptom, to a discrete brain area: it appears that, opposite to some neurological findings, the appearance of a psychological suffering is to be addressed to a set of incorrect integrative operations between different brain areas, rather than to a focused lesion. Anyway, it must be reported that this is not always true: there are cases of a depressive disorder caused by a focused neurological damage, such as a tumor, or a surgical wound, but even in those cases, the same symptomatology, as far as it can be depicted from the clinical observation, can be associated with wounds that lay in diverse parts of the brain [D'Angelo et al, 2008]. Moreover, non-responsive OCD disorders can be treated by cingulotomy or focused deep brain stimulation, but these treatments usually cannot predict the 100% of reduction of symptoms [Rauch et al, 2001[Rauch et al, , 2006Sachdev et al, 2001;Guarnieri et al, 2005], suggesting that the mechanism that leads to OCD only partially lays within a single brain area.…”

mentioning

confidence: 99%

Focus on HTR2C: A possible suggestion for genetic studies of complex disorders

Drago

Serretti

2009

American J of Med Genetics Pt B

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HTR2C is one of the most relevant and investigated serotonin receptors. Its role in important brain structures such as the midbrain, the lateral septal complex, the hypothalamus, the olfactory bulb, the pons, the choroid plexus, the nucleus pallidus, the striatum and the amygdala, the nucleus accumbens and the anterior cingulated gyrus candidate it as a promising target for genetic association studies. The biological relevance of these brain structures is reviewed by way of the focus on HTR2C activity, with a special attention paid to psychiatric disorders. Evidence from the genetic association studies that dealt with HTR2C is reviewed and discussed alongside the findings derived from the neuronatmic investigations. The reasons for the discrepancies between these two sets of reports are discussed. As a result, HTR2C is shown to play a pivotal role in many different psychiatric behaviors or psychiatric related disrupted molecular balances, nevertheless, genetic association studies brought inconsistent results so far. The most replicated association involve the feeding behavior and antipsychotic induced side effects, both weight gain and motor related: Cys23Ser (rs6318) and -759C/T (rs3813929) report the most consistent results. The lack of association found in other independent studies dampens the clinical impact of these reports. Here, we report a possible explanation for discrepant findings that is poorly or not at all usually considered, that is that HTR2C may exert different or even opposite activities in the brain depending on the structure analyzed and that mRNA editing activity may compensate possible genetically controlled functional effects. The incomplete coverage of the HTR2C variants is proposed as the best cost-benefit ratio bias to fix. The evidence of brain area specific HTR2C mRNA editing opens a debate about how the brain can differently modulate stress events, and process antidepressant treatments, in different brain areas. The mRNA editing activity on HTR2C may play a major role for the negative association results.

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“…It is true that some groups have found women with brain tumours to be more likely than men to become depressed [2,3]. However other researchers have not, including one of the authors of the review [4][5][6].…”

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confidence: 99%

Female gender is not a proven risk factor for depression in glioma

et al. 2009

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We read Litofsky and Resnick's timely and useful review of depression in brain tumour patients with interest [1]. The authors identified screening for depression as an issue requiring future study. Because screening is often targeted at high-risk groups, it is important to study the risk factors for depression in brain tumour patients.The authors state that female gender is a risk factor for depression in glioma. It is true that some groups have found women with brain tumours to be more likely than men to become depressed [2,3]. However other researchers have not, including one of the authors of the review [4][5][6].We sent a questionnaire to the GP of each glioma patient on our hospital database (Edinburgh, UK), asking whether their patient had suffered depression both before and since the diagnosis of glioma. The diagnosis of depression was based on the clinical judgement of each GP. Response rate was 68% (100/147; 55% male). A pre-glioma (past medical) history of depression was significantly more likely in women (12/45 women compared with 3/55 men; P = 0.004, Fisher's Exact Test). However following glioma presentation the sex difference in depression disappeared and men were equally as likely as women to experience depression (12/55 and 12/45 respectively; P = 0.64).Female gender is not a proven risk factor for depression in glioma. Since general population surveys consistently report that depression is twice as common in women [7], studies reporting a more equal sex distribution for depression in brain tumours may even suggest a relatively increased risk for men.We agree that depression in glioma is a fertile field for research. For now we suggest that men and women with glioma should be considered at equal risk of developing depression, and that efforts should therefore be made to include them equally in any proposed screening programmes.

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State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal study

Abstract: Patients affected by brain tumors frequently experience affective disorders. After brain surgery, a depressive state can develop. The psychometric assessment could be useful in these patients for quick recognition of psychological disorders.

Cited by 111 publications

References 27 publications

Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

Focus on HTR2C: A possible suggestion for genetic studies of complex disorders

Female gender is not a proven risk factor for depression in glioma

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