Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

Hickmann, Anne‐Katrin; Nadji-Ohl, Minou; Haug, Markus; Hopf, Nikolai J.; Ganslandt, Oliver; Giese, Alf; Renovanz, Mirjam

doi:10.1007/s00701-016-2844-y

Cited by 22 publications

(27 citation statements)

References 44 publications

(78 reference statements)

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“…The average percentage of men in the total sample was 51.3%. 17 studies assessed for depression or depressive symptoms using Hospital Anxiety and Depression Scale (HADS-D) [ 4 , 7 , 13 , 14 , 21 , 33 , 35 , 39 – 43 , 45 , 46 , 49 – 51 ], 6 used Beck Depression Inventory (BDI) [ 5 , 6 , 23 , 44 , 52 , 54 , 57 ], 2 used the Zung Self-Rating Depression Scale (Zung SDS) [ 51 , 58 ], 2 used Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition (DSM-IV) [ 12 , 47 ], 10 used other methods [ 19 , 20 , 22 , 24 , 34 , 36 , 37 , 48 , 53 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…6 studies were excluded because they are in lack of available raw data on prevalence of depression or their main focus is not on the outcome and effect of depression or depressive symptoms [ 39 , 50 , 52 , 53 , 55 , 70 ]. After analyzing the remaining 6 longitudinal studies [ 6 , 7 , 20 , 40 , 51 , 54 ], brain tumor patients presented with a slightly higher prevalence of depression in the follow-up period (Relative Increase Ratio:1.35, 95% CI(1.04, 1.76)) (P = 0.025) (Table 3 ). Sensitivity analysis for the secondary analysis revealed that Angelo’s study has substantial influence on the final result [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…But the prevalence is comparably lower than that in patients with diabetes and breast cancer, partly due to its rapid disease progression [ 72 – 76 ]. Brain tumor patients with depression or depressive symptoms are reported to have worse health related quality of life (HRQoL), elevated risk of suicide, more medical complications and worse survival [ 5 , 20 , 44 , 54 , 57 ]. Unfortunately, only part of patients with depression are properly treated [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Association between depression and brain tumor: a systematic review and meta-analysis

et al. 2017

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BackgroundPatients with brain tumor are in risk of depression or depressive symptoms, but the estimated prevalence varies between studies. The aim of this study is to get a proper summarized estimate of depression prevalence in brain tumor patients.MethodsLiterature search on Pubmed, PsycINFO, and Cochrane library from January 1981 through October 2016. The prevalence of depression or depressive symptoms in brain tumor patients was estimated by screening scales and analyzed using stratified meta-analysis and subgroup analysis. The prevalence of depression level or symptoms during the follow-up periods was detected by secondary analysis.ResultsAmong the 37 studies included in this meta-analysis, 25 used a cross-sectional design and 12 used longitudinal study. The pooled prevalence was 21.7% (971/4518 individuals, 95 % confidence interval (CI) 18.2%–25.2%) for overall sample. Lower prevalence was detected in studies with sample size ≥100 than <100, lower grade tumor than high grade tumor, studies using clinician-rated depression scales than self-rated or non-depression-specific ones, and in patients from UK, Germany and Italy than USA. After analyzing 6 longitudinal studies, prevalence of depression remained no change in the follow-up periods. No significant differences were observed between study designs and tumor types.ConclusionsThe estimated prevalence of depression or depressive symptoms among brain tumor patients was 21.7%, affected by depression assessment type, sample size, tumor grade and country. Diagnosis and treatment of co-morbid depression in brain tumor patients need to be addressed in future studies for better life quality and oncology management.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between depression and brain tumor: a systematic review and meta-analysis

et al. 2017

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“…In contrast, employment status was found to be significantly associated with functional status. A follow-up study conducted by Hickmann et al 32 reported a parallel trend of unemployment as the functional status declines. Though none of the studies have reported any definite association between unemployment and reduced functional status among similar populations, trends and figures explained by previous studies, as well as common sense, support this relationship, especially in countries without unemployment benefits or without adequate labour laws safeguarding employee rights during illnesses.…”

Section: Discussionmentioning

confidence: 97%

Depression among adult patients with primary brain tumour: a cross-sectional study of risk factors in a low–middle-income country

et al. 2020

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ObjectiveThe prevalence of depression among patients with primary brain tumour ranges from 15% to 40% globally. Several individual and clinical factors contribute to the development of depression. However, their association with depression in Pakistani setting has not yet been assessed. Thus, we aim to study the factors associated with depression among adult patients with primary brain tumour at a tertiary care hospital in Karachi, Pakistan.Study designA prospective cross-sectional study.SettingThis study was conducted at a tertiary care hospital of Karachi, Pakistan.ParticipantsThis study included 132 patients with confirmed diagnosis of primary brain tumour (initially diagnosed on MRI of the brain with contrast and later confirmed on histology of surgical specimen) in various stages of treatment.Primary outcomeThe primary outcome of this study was to assess depression and its associated factors among adult patients with primary brain tumour. Depression was assessed using a validated screening tool Patient Health Questionnaire-9 (PHQ-9). Scores of 10–27 on PHQ-9 were indicative of screen positive for depressive symptoms. A set of the structured pre-tested questions was used to evaluate patient-related, tumor-related and treatment-related factors.ResultsFifty-one (39%, CI: 33.33–46.94) patients in our study screened positive for depressive symptoms on PHQ-9. There was a significant association between depressive symptoms and Karnofsky Performance Scores (KPS) (prevalence ratio: 3.25 and CI: 1.87–5.62) after controlling covariates. Propensity scores predicted a positive association between KPS (functional status) and unemployment, treatment stage, and tumour recurrence. Tumor-related and treatment-related factors including tumour grade, location, type and hemispheric lateralisation were found insignificant.ConclusionDepression is common in patients with primary brain tumour. Impaired functional status has a direct impact on depression in these patients. Incorporating the psychosocial domain earlier in the course of treatment needs to be considered for better neuro-oncology management of patients with primary brain tumour.

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“…Brain tumours may be accompanied by a number of comorbidities. While brain tumours may directly affect patients’ cognition, mobility, communication, perception and other neurological functions, these comorbidities may also greatly affect patients’ quality of life 2 8–10. Among these comorbidities, depression is the most common 2 8.…”

Section: Discussionmentioning

confidence: 99%

Temporal glioblastoma presenting as catatonia

Franssen

Sienaert

2019

BMJ Case Rep

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The objective of this article is to describe the possible association of catatonia and temporal brain lesions. This is a case presentation of a 57-year-old man presenting with depression, with catatonia secondary to a temporal glioblastoma. He was referred to hospital because for a sudden deterioration in depressed state. He was diagnosed with catatonia and treated successfully with lorazepam. During his admission, he became increasingly disinhibited, and an MRI scan revealed an intracranial mass in the right temporal lobe, with uncal herniation and a mass effect. Surgical resection of the entire tumour was successful. Histological examination revealed a glioblastoma multiforme requiring additional chemoradiotherapy. Postoperatively, catatonic signs and symptoms were not detectable. A postsurgical frontal syndrome with disinhibition and logorrhoea was present and gradually normalised over the course of several weeks. Catatonia can be the presenting symptom of a temporal brain tumour, and should therefore prompt the physician to a thorough medical investigation.

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Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

Cited by 22 publications

References 44 publications

Association between depression and brain tumor: a systematic review and meta-analysis

Association between depression and brain tumor: a systematic review and meta-analysis

Depression among adult patients with primary brain tumour: a cross-sectional study of risk factors in a low–middle-income country

Temporal glioblastoma presenting as catatonia

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