STAT5A encoding gene maps to Chromosome 19 in cattle and goat and to Chromosome 11 in sheep

Goldammer, Tom; Meyer, Lutz; Seyfert, Hans‐Martin; Brunner, Ronald M.; Schwerin, Manfred

doi:10.1007/s003359900547

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…A single STAT5 gene was initially identified in sheep, but subsequently two forms of STAT5 (STAT5A and STAT5B) encoded by two different but chromosomally linked genes have been identified in mouse, human, rat, and cattle cells (Hou et al 1995;Kazansky et al 1995;Lin et al 1996;Liu et al 1995;Mui et al 1995;Ripperger et al 1995;Silva et al 1996, Goldammer et al 1997. The genes encoding STAT5A and STAT5B are highly homologous, being *90% identical in coding sequence.…”

Section: Introductionmentioning

confidence: 96%

Analysis of STAT5A/AvaI Gene Polymorphism in Four Italian Cattle Breeds

Dario

Ciotola

et al. 2009

Biochem Genet

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The STAT5A/AvaI polymorphism was investigated with PCR-RFLP in a sample of 339 cattle belonging to four breeds: Italian Friesian, Jersey, Italian Brown, and Podolica reared in south Italy. All three possible genotypes for the C/T polymorphism were identified. In these breeds, PCR-RFLP showed the predominance of the TT genotype in Italian Brown and Jersey cows; in Podolica and Italian Friesian CT is the most frequent genotype. The frequency of the T allele ranged from 0.55 to 0.81 in the analyzed populations. The distribution of genotypic and allelic frequencies at this locus was significantly different among the four populations based on a chi2 test (P < 0.001), suggesting that the molecular characteristics of the STAT5A gene could be significantly affected by the breed selection. Gene heterozygosity, gene homozygosity, effective allele number, fixation index, and polymorphism information content (PIC) were calculated. The observed heterozygosity, as well as the Ne and PIC values, indicates high genetic variability in the Podolica breed. Podolica could be considered an interesting reservoir of genetic diversity for a species under high selective pressure elsewhere.

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Section: Introductionmentioning

confidence: 96%

Analysis of STAT5A/AvaI Gene Polymorphism in Four Italian Cattle Breeds

Dario

Ciotola

et al. 2009

Biochem Genet

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“…Initially a single STAT5 gene was identified in sheep but subsequently two forms of STAT5 (STAT5A and STAT5B), encoded by two different genes, have been identified in mouse, human, rat and cattle cells (Hou et al, 1995;Kazansky et al, 1995;Liu et al, 1995;Mui et al, 1995;Ripperger et al, 1995;Lin et al, 1996;Silva et al, 1996;Goldammer et al, 1997). The genes encoding STAT5A and STAT5B are highly homologous, being~90% identical in coding sequence; the two isoforms differ by few amino acids in the carboxylic end of the protein molecule corresponding to COOH-terminal transcription activation domains (Moriggl et al, 1996).…”

Section: Introductionmentioning

confidence: 98%

STAT5A/AvaI polymorphism in Podolica bulls and its effect on growth performance traits

et al. 2009

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“…STAT5 exists in two isoforms -A and B, which differ by a few amino acids in the carboxylic end of the protein molecule; separate genes code both of them (Seyfert et al, 2000). In goat, the STAT5A gene was located at chromosome 19 (Goldammer et al, 1997). Antoniou et al (1999) described two SSCP variants of the gene fragment that encodes the SH2 domain in bovine STAT5A protein.…”

Section: Dgat1mentioning

confidence: 99%

Polymorphism identification in goat DGAT1 and STAT5A genes and association with milk production traits

An¹,

Hou²,

Zhao³

et al. 2013

CZECH J ANIM SCI

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Polymorphisms of DGAT1 and STAT5A genes in Xinong Saanen and Guanzhong goat breeds were investigated. PCR-RFLP, SSCP, and DNA sequencing were used to identify three SNPs: DQ380250:g.407_408insC in the DGAT1 gene, AJ237937:g.6798C>T and g.6852C>T in the STAT5A gene. In DGAT1 g.407_408insC locus, the frequencies of C -allele were 0.79-0.85, and frequencies of C + allele were 0.21-0.15. At STAT5A g.6852C>T locus, frequencies of C allele were 0.70-0.72, and frequencies of T allele were 0.30-0.28. Compared with goats with DGAT1 C -C -, those with C -C + genotype had greater milk fat (P < 0.05). The goats with STAT5A CT had greater milk yield than those with CC genotype (P < 0.05). The results showed that does with C -C -CT and C -C + CT yielded more milk than those with C -C -CC (P < 0.05). In addition, does with C -C + CT had the highest milk fat in comparison with other combination genotypes (P < 0.05).

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STAT5A encoding gene maps to Chromosome 19 in cattle and goat and to Chromosome 11 in sheep

Cited by 13 publications

References 16 publications

Analysis of STAT5A/AvaI Gene Polymorphism in Four Italian Cattle Breeds

Analysis of STAT5A/AvaI Gene Polymorphism in Four Italian Cattle Breeds

STAT5A/AvaI polymorphism in Podolica bulls and its effect on growth performance traits

Polymorphism identification in goat DGAT1 and STAT5A genes and association with milk production traits

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