Stasis dermatitis-like leukaemic infiltration in a patient with myelodysplastic syndrome

Abstract

We report a case of leukaemia cutis presenting as stasis dermatitis-like eruption in a patient with myelodysplastic syndrome progressing to acute myelogenic leukaemia.

Extensive cutaneous manifestations: Presenting feature of chronic myelocytic leukemia in second blast crisis

“…[23] Other unusual manifestations include erythema nodosum, erythema annulare centrifugum, pyoderma gangrenosum, lesions mimicking urticaria, guttate psoriasis, vitiligo, stasis dermatitis and subungual leukemia cutis. [378] LC may also occur within established scars and within recent areas of trauma. [9] It is important to bear in mind the varied clinical presentations of LC so as to facilitate its early diagnosis and timely treatment.…”

Cutaneous manifestations in relation to immunologic parameters in a cohort of primary myelodysplastic syndrome patients

“…Among the cutaneous manifestations seen in MDS, leukaemia cutis represents an important finding because it can be used as a surrogate marker of early transformation of the haematologic disease 8,21 . Skin infiltration as a site of extra‐medullary involvement identifies patients needing early initiation of chemotherapy for acute leukaemia, which in MDS is associated with poor prognosis and refractoriness to treatment 21,22 . The temporal association between leukaemia cutis and acute leukaemia is highly variable.…”

“…8,21 Skin infiltration as a site of extra-medullary involvement identifies patients needing early initiation of chemotherapy for acute leukaemia, which in MDS is associated with poor prognosis and refractoriness to treatment. 21,22 The temporal association between leukaemia cutis and acute leukaemia is highly variable. In the setting of established acute leukaemia, it tends to develop late.…”

“…Regarding MDS, leukaemia cutis frequently develops before or concomitantly with identifiable leukaemic transformation in blood or in the bone marrow. 8,22 According to Longacre, the interval between skin biopsy diagnosis and the appearance of leukaemia varied from 3 weeks to 20 months (average, 6 months). 23 In our cohort, leukaemia cutis preceded the MDS diagnosis by 2 months.…”

Leukemia Cutis in a patient with Chronic Myeloid Leukemia

“…(2,3)Other unusual manifestations include erythema nodosum, erythema annulare centrifugum, pyoderma gangrenosum and lesions mimicking urticaria, guttate psoriasis, vitiligo, stasis dermatitis and subungual leukemia cutis. (3,7,8)It may also occur within established scars and within recent areas of trauma. (9) The varied clinical presentations of LC must be borne in mind so as to facilitate early diagnosis and timely treatment.…”