Cutaneous manifestations in relation to immunologic parameters in a cohort of primary myelodysplastic syndrome patients

Dalamaga, Maria; Karmaniolas, Konstantinos; Matekovits, Athina; Migdalis, Ilias; Papadavid, E.

doi:10.1111/j.1468-3083.2007.02520.x

Cited by 52 publications

(44 citation statements)

References 30 publications

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] The specific lesions are comprised of a dermal infiltrate of malignant hematopoietic cells, also known as leukemia cutis. [1][2][3][4] These skin lesions are rare, linked to a rapid progression of MDS, indicate blastic transformation to acute leukemia, and infer a poor prognosis. [1][2][3][4][5] The nonspecific cutaneous eruptions are more common and include neutrophilic dermatoses, cutaneous vasculitis, and cutaneous infections.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Recognizing these skin manifestations is important as they can precede blood or bone marrow transformation to leukemia and are associated with a poor prognosis. [1][2][3][4][5] Interstitial granulomatous dermatitis (IGD) is a heterogeneous inflammatory reaction pattern associated with a variety of systemic illnesses and conditions including connective tissue disorders, vasculitides, infections, drug reactions, and lymphoproliferative disorders, such as lymphoma [31][32][33][34] and multiple myeloma, 35 but less commonly with leukemia. 36,37 We report a case of a cutaneous IGD-like eruption presenting as a nonspecific cutaneous manifestation of MDS, with subsequent development into acute myeloid leukemia with leukemia cutis.…”

Section: Introductionmentioning

confidence: 99%

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A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

Cornejo

Lum²,

Izumi³

2013

The American Journal of Dermatopathology

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Cutaneous manifestations associated with myelodysplastic syndromes (MDS) are uncommon and can occur as specific or nonspecific lesions. Recognizing these cutaneous manifestations is important as they can precede blood or bone marrow transformation to leukemia. Granulomatous reactions have rarely been described as nonspecific lesions of MDS. These rare cases histologically resembled granuloma annulare, sarcoid, and a generalized dermal interstitial granulomatous dermatitis (IGD) which were not associated with leukemic infiltration. The authors report an interesting case of an IGD-like eruption evolving over the course of MDS with eventual progression to systemic leukemia. IGD is an inflammatory reaction that refers to a varied spectrum of histologic patterns and is associated with a variety of systemic illnesses and hypersensitivity reactions, including lymphoma and leukemia. In patients with MDS, surveillance for leukemia is a critical component of their follow-up care. Normally, this surveillance occurs through serial peripheral blood smears and bone marrow studies. IGD-like eruptions are a cutaneous reaction pattern that may serve as an additional clinical indicator of leukemic progression in patients with MDS. Although primarily a reactive pattern, this entity can rarely harbor leukemic blasts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

Cornejo

Lum²,

Izumi³

2013

The American Journal of Dermatopathology

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“…Several other studies have also found AICs to be associated with younger age [17,18], high-risk disease features [17,19,20], and hypergammaglobulinemia [19]. Female gender correlated with AICs in some reports [12,21].…”

Section: Does Autoimmunity Correlate With Specific Clinical Charactermentioning

confidence: 92%

Autoimmunity and Inflammation in Myelodysplastic Syndromes

Wolach

Stone²

2016

Acta Haematol

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Autoimmune and inflammatory conditions (AICs) are encountered in up to 25% of patients with myelodysplastic syndromes (MDS). A wide range of AICs have been reported in association with MDS and can range from limited clinical manifestations to systemic diseases affecting multiple organs. Vasculitides, connective tissue diseases, and inflammatory arthritis are frequently reported in different studies; noninfectious fever and constitutional symptoms at presentation are common. Associations between AICs and specific MDS characteristics vary by study, but the available data suggest that AICs cluster more often in younger patients with higher-risk MDS. In general, AICs do not seem to confer worse survival, although certain AICs may be associated with adverse outcome (e.g. vasculitis) or progression of MDS (Sweet's syndrome). Nonetheless, these complications may have a significant impact on quality of life and affect the timing and type of MDS-directed therapy. The mainstay of management of these complications in the short term relies on immunosuppressive drugs. Increasing evidence suggests that hypomethylating agents may be effective in treating these complications and reduce steroid dependence. While the pathogenesis of AICs is incompletely understood, growing appreciation of cellular immune deregulation, cytokine hypersecretion, and the genetic heterogeneity underlying MDS may improve our understanding of common pathways linking MDS, inflammation, and autoimmunity.

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“…Umgekehrt findet sich therapieunabhän-gig eine erhöhte Inzidenz von MDS/AML im Kontext primärer Autoimmunerkrankungen [7,8]. Unter den AIM bei MDS dominieren vaskulitische Syndrome, insbesondere in kutaner Manifestation [9]. …”

Section: Mds-assoziierte Autoimmunphänomeneunclassified

Myelodysplastisches Syndrom, akute Leukämie und Stammzelltransplantation

et al. 2017

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Cutaneous manifestations in relation to immunologic parameters in a cohort of primary myelodysplastic syndrome patients

Abstract: Most MDS patients with cutaneous manifestations belong to the high-risk MDS subgroup and present hypergammaglobulinemia. Early biopsy of skin lesions in myelodysplasia is indicated.

Cited by 52 publications

References 30 publications

A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

A Cutaneous Interstitial Granulomatous Dermatitis-Like Eruption Arising in Myelodysplasia With Leukemic Progression

Autoimmunity and Inflammation in Myelodysplastic Syndromes

Myelodysplastisches Syndrom, akute Leukämie und Stammzelltransplantation

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