This study explores the challenges of integrating macro, meso, and micro in the articulation of advanced innovation policy and examines, respectively, dimensions of public business support, intermediary organizations, and knowledge transfer. It conducts an integrative review of the pertinent literature and a bibliometric analysis of 440 articles. It reveals three major obstacles that seemingly impede the effective integration of macro, meso, and micro in contemporary policymaking and socioeconomic analyses: entrenched boundaries between different thematic areas, methodological discrepancies, and the relative lack of integrated theoretical models. These factors contribute to the absence of unified functional hubs focused on microlevel interventions. The proposed Institutes of Local Development and Innovation (ILDIs) could mitigate these challenges as they are presented as multilevel policy instruments intended to provide support to businesses—particularly to those facing chronic and structural problems.