Startreaktionen des posttraumatischen Schocks — Reperfusionsschaden

Schlag, G.; Redl, Heinz

doi:10.1007/978-3-642-75920-8_8

Cited by 2 publications

(1 citation statement)

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“…activated neutrophils and by the endothelial intraOxygen-derived free radicals are increasingly recog-cellular route by the hypoxanthine/xanthine oxidase 1 ) nized as the major cause of mono or multiple organ system. Many experimental data show the beneficial failure, and for reperfusion injury in different organs effect of an antioxidant treatment to prevent or to (1)(2)(3). These radicals are produced extracellularly by minimize oxidant-mediated tissue damage; such antioxidants include allopurinol, oxypurinol, tungsten, Superoxide dismutase 1 ), catalase 1 ), dimethyl sulphox-) Enzymes , .…”

Section: Introductionmentioning

confidence: 99%

Effect of Ascorbic Acid on Neutrophil Functions and Hypoxanthine/Xanthine Oxidase-Generated, Oxygen-Derived Radicals

Dwenger

Funck²,

Lueken³

et al. 1992

Clinical Chemistry and Laboratory Medicine

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Summary:The effect of ascorbic acid on neutrophil functions was investigated.The chemiluminescence of isolated neutrophils, stimulated with N-fonnyl-L-methionyl-L-leucyl-L-phenylalanine, latex, lipopolysaccharide from Escherichia coli, zymosan A, or 4 -phorbol 12 -myristate 13a-acetate was inhibited up to 99% by the dose-dependent oxygen radical scavenging activity of 6 mmol/1 ascorbic acid. The chemiluminescence of neutrophils in blood, stimulated with 4 -phorbol 12 -myristate 13a-acetate, or with zymosan A was inhibited 35% or 48%, respectively, by 6 mmol/1 ascorbic acid.Ascorbic acid, up to 6 mmol/1, did not inhibit the release of -N-acetylglucosaminidase and elastase from isolated neutrophils activated by the above stimulatory agents.During neutrophil/nylon fibre interaction ascorbic acid reduced the oxygen radical production dose-dependently (77% inhibition of the chemiluminescence response at 6 mmol/1 ascorbic acid), whereas the adherence was unaffected. Hypoxanthine/xanthine oxidase-generated oxygen radicals were scavenged by ascorbic acid in a dose-dependent manner (99% inhibition of the chemiluminescence response at 100 μιηοΐ/ΐ ascorbic acid).From these results, ascorbic acid can highly be recommended for animal experiments and clinical studies in patients with trauma, shock and sepsis and for studies to prevent or reduce reperfusion injuries.

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Section: Introductionmentioning

confidence: 99%