Ischämie-/Reperfusions-Syndrom - Das Serummyoglobin im Verlauf und seine Wertigkeit als Prognoseparameter

Fricke, P.M.; Weiß, G.; Lippert, H.

doi:10.1007/s003900200004

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In the previous study performed by Fricke et al, they indicated that the level of Mb could predict the extent of impairment after revascularization ( 32 ). When Mb was more than 20,000 µg/L, there was an obvious correlation with organ failure.…”

Section: Discussionmentioning

confidence: 98%

“…Thus, the pathophysiological of Mb predicting utility for EAD after LT was unclear. A previous study discovered that the level of serum Mb peaked a few hours after reperfusion during surgery ( 32 ), and quick reperfusion may help reduce Mb release into the bloodstream. Clinically, serum myoglobin can be partially removed by continuous renal replacement therapy and hemoperfusion.…”

Section: Discussionmentioning

confidence: 99%

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Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation

Zhang

Han

et al. 2022

Front. Surg.

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BackgroundEarly allograft dysfunction (EAD) is a common postliver transplant complication that has been associated with graft failure and risk for poor prognosis. There are many risk factors for the incidence of EAD after liver transplantation (LT). This study investigated whether elevated postoperative myoglobin (Mb) increases the incidence of EAD in liver transplanted recipients.MethodsA total of 150 adult recipients who measured Mb within 3 days after liver transplantation between June 2019 and June 2021 were evaluated. Then, all patients were divided into two groups: the EAD group and the non-EAD group. Univariate and multivariate logistic regression analyses were performed, and receiver operating characteristic curves (ROCs) were constructed.ResultsThe incidence of EAD was 53 out of 150 patients (35.3%) in our study. Based on the multivariate logistic analysis, the risk of EAD increased with elevated postoperative Mb (OR = 1.001, 95% CI 1.000–1.001, P = 0.002). The Mb AUC was 0.657, and it was 0.695 when combined with PCT. When the subgroup analysis was conducted, the AUC of serum Mb prediction was better in patients whose preoperative model for end-stage liver disease score ≤ 15 or operative time ≥ 10 h (AUC = 0.751, 0.758, respectively, or 0.760, 0.800 when combined with PCT).ConclusionElevated Mb significantly increased the risk of postoperative EAD, suggesting that postoperative Mb may be a novel predictor of EAD after liver transplantation.The study was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR2100044257, URL: http://www.chictr.org.cn).

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation

Zhang

Han

et al. 2022

Front. Surg.

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Prognostic value of serum myoglobin in patients after cardiac surgery

et al. 2007

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Relation between Serum Pro-Brain Natriuretic Peptide, Myoglobin, CK Levels and Morbidity and Mortality in High Voltage Electrical Injuries

et al. 2010

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Objective In our study, in addition to evaluating the relation between Pro-Brain natriuretic peptide (Pro-BNP), myoglobin and creatinine kinase (CK) levels and morbidity and mortality, we aimed at identifying the demographic characteristics of patients admited to emergency service after exposure to high electrical voltage. Methods In this prospective study, 48 emergency service patients exposed to high electric voltage were included; 19 healthy individuals were included as the control group. Their blood samples and electrocardiographies (ECG) were taken at the time of recourse upon their written approval. Demographic data and laboratory data were checked and compared among the patient group. We investigated the correlation between inpatients that had special clinical manifestations (escaratomy, fasciotomy, exitus, myoglobulinuria, third-degree burn, arrhythmia and etc.) and serum Pro-BNP, myoglobin and CK levels. Results When serum Pro-BNP, myoglobulin and CK levels were compared for the special clinical manifestations; the pro-BNP levels were statistically significantly higher in patients who had arrhythmia than in those without arrhythmia, and significantly higher in patients who died than in those who healed (respectively p= 0.002 and p=0.007). In contrast, serum CK and myoglobin levels were not statistically significant. The serum CK and myoglobin levels were statistically significantly higher in patients who had third-degree burn than the others (p<0.001). Conclusion Serum pro-BNP level is a marker that can be used for mortality and morbidity with patients exposed to high voltage electrical injuries.

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Ischämie-/Reperfusions-Syndrom - Das Serummyoglobin im Verlauf und seine Wertigkeit als Prognoseparameter

Cited by 3 publications

References 11 publications

Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation

Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation

Prognostic value of serum myoglobin in patients after cardiac surgery

Relation between Serum Pro-Brain Natriuretic Peptide, Myoglobin, CK Levels and Morbidity and Mortality in High Voltage Electrical Injuries

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