Starch-based coatings for colon-specific delivery. Part II: Physicochemical properties and in vitro drug release from high amylose maize starch films

Structure and colon-targeted releasing property of resistant octenyl succinate starch

“…Recent research on the utilization of the metabolic activity and the colonic microenvironment has attained great value in the design of novel colon-targeted delivery systems based on polysaccharides (de Vos, Faas, Spasojevic, & Sikkema, 2010). Polysaccharides which can avoid digestion and are poorly permeable for the bioactive components in the upper gastrointestinal tract (GIT) but can be digested by the enzymes produced by the colonic microbiota or permeable for the bioactive components after arrival in the colon were identified as key carriers for colonic drug delivery systems (Freire, Podczeck, Veiga, & Sousa, 2009;Kosaraju, 2005). A variety of polysaccharides has been investigated, but the most successful to date is resistant starch (RS).…”

Preparation and in vitro Release Mechanisms of Modified Pectin Matrix Tablets for Colon-Targeted Drug Delivery

“…The surface morphology of the pectin was analyzed using previously reported methods, with slight modification (Varshosaz et al 2012;Meneguin et al 2014). The surface characteristics of the pectin and MAP were analyzed using a scanning electron microscope (Hitachi, S-3400N, Tokyo, Japan).…”

“…The FTIR analysis of the tablets was carried out as previously described by Newton et al (2012), with slight modification. A Spectrum One spectrophotometer (Nexus 470 FTIR, Tianjin, China) equipped with a universal attenuated total reflectance device was used.…”

“…To overcome these issues, much of the recent work in the field has focused on novel colontargeted delivery systems based on polysaccharides (de Vos et al 2010;Rudzinski et al 2016;Seeli and Prabaharan 2017). Polysaccharides may be effective carriers for colonic delivery systems because many can avoid digestion by the bioactive components in the upper gastrointestinal tract, but can then be digested by the enzymes produced by colonic microbiota or by the bioactive components of the colon (Freire et al 2009;Gadalla et al 2016).…”

Mechanical properties and total hydroxycinnamic derivative release of starch/glycerol/Melissa officinalis extract films

“…The evolution in the polymeric area fostered the development of new pharmaceutical drug delivery systems, which can maintain the active principle in the target site for a longer period, for example through use of bioadhesive gels and transdermic films. Polymeric films have a number of advantages for chronic treatment, because they typi-cally promote gradual and prolonged release of the active principles, leading to better patient adherence to treatment (Freire et al, 2009;Vila Jato, 1995;Veiga, 1988).…”