Star-shaped polymers having PEO arms

Łapienis, Grzegorz

doi:10.1016/j.progpolymsci.2009.04.006

Cited by 223 publications

(167 citation statements)

References 372 publications

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“…In aqueous environments, they spontaneously aggregate into micelle-like aggregates via hydrophobic-hydrophobic interactions [4]. Polymeric nano-aggregates can be formed from a diverse range of architectures including block copolymers [5], graft polymers [6], star shaped polymers [7] and dendrimers [8].…”

Section: Introductionmentioning

confidence: 99%

Poly(allylamine) Magnetomicelles for Image Guided Drug Delivery

Barnett¹,

Lees²,

Curtis³

et al. 2013

PNT

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Section: Introductionmentioning

confidence: 99%

Poly(allylamine) Magnetomicelles for Image Guided Drug Delivery

Barnett¹,

Lees²,

Curtis³

et al. 2013

PNT

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“…Segmented stars are those bearing at least two kinds of segments (block) either as pure arms or as block copolymer arms. A number of synthetic strategies have been developed, based on "living" controlled polymerization methods that have led to a variety of star copolymers, consisting of two different monomers, and terpolymers (comprising three types of repeating units), exhibiting specific block/arm topologies [8][9][10][11][12][13][14][15][16][17]. Schematic representation of a number of different segmented stars is shown in Scheme 1; the aqueous solution properties of which are demonstrated in the present review.…”

Section: Star-shaped Topologiesmentioning

confidence: 99%

Water-Soluble Stimuli Responsive Star-Shaped Segmented Macromolecules

Iatridi

Tsitsilianis

2011

Polymers

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Star shaped segmented macromolecules constitute an interesting class of polymeric materials whose properties differ remarkably from those appearing in their linear counterparts. This review highlights the work done in the last decade, dealing with the self-assembly of star-shaped block copolymers and terpolymers of various topologies in aqueous media. This article focuses on a specific class of star shaped macromolecules designated as stimuli responsive. These stars bearblock/arms undergo sharp phase transitions upon responding to stimuli, such as temperature, pH, ionic strength and so forth. These transitions impose dramatic transformations on the morphology and, accordingly, in the functionality of the nanostructured associates. The number of arms, the specific functionality and topology of the different arm/blocks and the overall macromolecular architecture of the star polymer, significantly influence their behavior in terms of self-assembly and responsiveness.

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“…If poly(ethylene oxide) (PEO) is used as the shell, "stealth"-behavior can be observed, also known as "PEGylation", preventing the recognition of such materials by our immune system. This renders such approaches suitable for the preparation of long-circulating polymer-based drug nanocontainers [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…For the synthesis of star-shaped block copolymers, mainly two approaches have been employed, the divergent ("core-first") and the convergent ("arm-first") method [20,[23][24][25][26][27]. The divergent approach uses a multifunctional initiator, but typically not all initiation sites are easily accessible, which drastically influences the number of arms and the overall degree of polymerization.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the core block, PEO-based materials of different architectures have been thoroughly investigated concerning solution behavior [35,36] or the possibility of being scaffolds in medical applications [19,20,22]. The outer block, poly(2-ethyl-2-oxazoline) (PEtOx), is water-soluble and non-toxic, and the pseudo-peptide character of this material has been shown to induce similar "stealth" behavior, as observed for PEO [19,22,[37][38][39].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) (PEO-b-PEtOx) Star Block Copolymers

et al. 2013

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Abstract:We demonstrate the synthesis of star-shaped poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) [PEO m -b-PEtOx n ] x block copolymers with eight arms using two different approaches, either the "arm-first" or the "core-first" strategy. Different lengths of the outer PEtOx blocks ranging from 16 to 75 repeating units were used, and the obtained materials [PEO 28 -b-PEtOx x ] 8 were characterized via size exclusion chromatography (SEC), nuclear magnetic resonance spectroscopy (NMR), and Fourier-transform infrared spectroscopy (FT-IR) measurements. First investigations regarding the solution behavior in water as a non-selective solvent revealed significant differences. Whereas materials synthesized via the "core-first" method seemed to be well soluble (unimers), aggregation occurred in the case of materials synthesized by the "arm-first" method using copper-catalyzed azide-alkyne click chemistry.

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Star-shaped polymers having PEO arms

Cited by 223 publications

References 372 publications

Poly(allylamine) Magnetomicelles for Image Guided Drug Delivery

Poly(allylamine) Magnetomicelles for Image Guided Drug Delivery

Water-Soluble Stimuli Responsive Star-Shaped Segmented Macromolecules

Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) (PEO-b-PEtOx) Star Block Copolymers

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