Star-like dextran-polyacrylamide polymers: Prospects of use in nanotechnologies

Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin

“…The choice of this copolymer among the series of the branched samples synthesized is based on our previous research. Namely, this sample was the most efficient polymer matrix for the Ag sol in situ synthesis [24,25,29].…”

“…The details of the synthesis, identification, and analysis of the internal polymer structure were described in [25,27]. The theoretical number of grafting sites per polysaccharide backbone for the sample we used as a polymer nanocarrier in the present work was equal to 5, and the related dextran-graftpolyacrylamide copolymer was referred as D70-g-PAA.…”

“…As a nanocarrier, we used a branched copolymer obtained by grafting polyacrylamide (PAA) chains onto dextran ( = 7 × 10 4 g/mol −1 ) backbone [25], by using the ceric-ion-reduce initiation method. This redox process initiates free radical sites exclusively on the polysaccharide backbone, thus preventing from the formation of a polyacrylamide homopolymer.…”

“…The theoretical [22,23] and experimental [24][25][26][27][28][29] studies of branched polymers provide us with a reason to assume that these macromolecules are more efficient in comparison with linear analogs for the nanosystem in situ synthesis, as flocculants and nanocarriers for drugs, because of a higher local concentration of functional groups capable of reacting with some substances. It was proved by our recent research devoted to the encapsulation of cis-Pt into a branched star-like polymer with dextran core and grafted polyacrylamide-co-polyacrylic acid arms.…”

“…It was reported [25] that Ag sol synthesized in situ in a polymer solution Dextran-graft-(Polyacrylamide-co-Polyacrylic acid) was stable in time. The binary Polymer/AgNPs and ternary Polymer/AgNPs/cis-Pt nanosystems were tested for cytotoxic effects [29].…”