Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin

Kutsevol, N.; Naumenko, A. P.; Chumachenko, V.; Yeshchenko, Oleg A.; Kuziv, Yuliia; Pavlenko, Vadim A.

doi:10.15407/ujpe63.6.513

Cited by 7 publications

(6 citation statements)

References 39 publications

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“…A significant increase in the toxic properties of three-component nanocomposite 1 and nanocom- Similar effects of decreasing the efficiency of polymer nanosystems loaded with active components toward a damage of cancer cells were revealed, when the number of these components increased [12,18]. As was reported in [12], the water-soluble polymer nanocarriers such as dextran-graft-(polyacrylamideco-polyacrylic acid) loaded with chemotherapeutic substances Cisplatin demonstrated a high toxicity to cancer cells.…”

Section: Resultsmentioning

confidence: 56%

“…However, it is difficult to predict the behavior of multicomponent nanosystems, because the adding of any additional component or some temperature changes can provoke the aggregation. It can lead to the loss of a biological activity of the nanocomposite [18].…”

Section: Resultsmentioning

confidence: 99%

“…However, when the copolymers were conjugated to both nanosilver and Cisplatin, such a nanosystem displayed a less cytotoxic effect compared to the conjugates of Dextran-graft-polyacrylamide and Cisplatin [12]. Such effect was caused by the aggregation in a multicomponent system [13].…”

Section: Introductionmentioning

confidence: 98%

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Experimental Approach to the Creation of Efficient Multicomponent Nanocomposites for Antitumor Therapy

et al. 2020

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Water-soluble polymers with special characteristics can be used as carriers in which the active ingredients are entrapped, encapsulated, adsorbed, or chemically attached. The understanding of the processes occurring during the formation of multicomponent nanosystems is the urgent task for the synthesis of antitumor nanocomposites. Gold nanoparticles (AuNPs), photosensitizer Chlorine e6 (Ce6), and Doxorubicin (Dox) are currently used for the photodynamic therapy and chemotherapy. We have been focused on the study of three-component nanosystems Polymer/AuNPs/Ce6, and four-component nanosystems Polymer/AuNPs/Ce6/Dox at physiological temperatures (37 ∘C). The star-like copolymer with Dextran core and grafted Polyacrylamide chains in nonionic and anionic forms are used as a matrix for the synthesis of nanocomposites. The nanosystems are characterized by the dynamic light scattering and transmission electron microscopy. The increasing of the aggregation processes for the four-component nanosystem Polymer/AuNPs/Ce6/Dox in comparison with the three-component one Polymer/AuNPs/Ce6 is registered. These nanosystems are tested in vitro against the subline of breast carcinoma MCF-7/S – sensitive to cytostatics. It is demonstrated that the increase of the aggregation process occurring in four-component systems leads to the loss of the antitumor activity of multicomponent drugs.

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Section: Resultsmentioning

confidence: 56%

Section: Resultsmentioning

confidence: 99%

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Experimental Approach to the Creation of Efficient Multicomponent Nanocomposites for Antitumor Therapy

et al. 2020

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“…In our previous work, it was shown that LCST depends on the polymer molecular structure [9]. It was shown [10,11], that the incorporation of an additional component into the polymer nanocarrier results in a change in the hydrophilic-hydrophobic balance of the polymer macromolecule. This process can lead to a significant aggregation of the polymer resulted in a loss of the pharmakinetic efficacy of the nanocomposite with incorporated antitumor drugs such as cisplatin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Dextran-Poly(N-Isopropylacrylamide) Copolymer as a Potential Temperature-Dependent Nanocarrier for Photosensitizers with Different Properties

et al. 2020

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Thermosensitive polymer poly-N-isopropylacrylamide (PNIPAM) having a conformational transition in the interval of physiological temperatures was discussed last years as a novel drug delivery system. Chlorin e6 (Ce6) is a photosensitizer used in the photodynamic anticancer therapy. The comparative study of the encapsulation of Ce6 and its derivative, dimethylether of chlorine e6 (DME Ce6), into a water-soluble star-like PNIPAM-based copolymer to prevent the aggregation of a photosensitizer in the water medium is carried out. The photophysical properties of the copolymer/photosensitizer complexes as functions of the temperature in the region of the conformational transition of the polymer matrix have been studied and discussed. It is shown that Ce6 at low temperatures interacts weakly with the polymer phase. As a result, the absorption and fluorescence properties of Ce6 in aqueous and polymer solutions are practically identical. Fluorescence characteristics of Ce6 in a copolymer solution remain unchanged, when it is heated, which indicates the lack of a possibility for this sensitizer to bind in the bulk of the polymer phase. Following fluorescence data, all DME Ce6 molecules are bound with the polymer matrix, when a temperature is higher than the Lower Critical Solution Temperature (LCST) of the polymer. The formed complexes are quite stable. In the presence of serum proteins, the molecules of the photosensitizer remain associated for a long time with the polymer. At temperatures below LCST, DME Ce6 is not bound by the polymer. Moreover, the cooling of a solution of DME Ce6/polymer complexes leads to the rapid dissociation of photosensitizer molecules with subsequent aggregation or binding to biological structures in an aqueous medium. The obtained results show that the possibility of using the polymer PNIPAM as a temperature-dependent nanocarrier strongly depends on the properties of the loaded drug.

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“…This can shorten the treatment time and decrease the drug dosage. In this respect, PNIPAM has been proposed as a stimuli responsive carrier of NPs [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Laser-Driven Aggregation in Dextran–Graft–PNIPAM/Silver Nanoparticles Hybrid Nanosystem: Plasmonic Effects

et al. 2020

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The laser-induced aggregation in the thermosensitive dextran grafted-poly(N-isopropylacrylamide) copolymer/Ag nanoparticles (D–g–PNIPAM/AgNPs) hybrid nanosystem in water has been observed. The laser-induced plasmonic heating of Ag NPs causes the Lower Critical Solution Temperature (LCST) conformation transition in D–g–PNIPAM/AgNPs macromolecules which shrink during the transition. The shrinking decreases sharply the distance between the silver nanoparticles that launches the aggregation of Ag NPs and the appearance of plasmonic attractive optical forces acting between the nanoparticles. It has been shown that the approach of the laser wavelength to the surface plasmon resonance in Ag nanoparticles leads to a significant strengthening of the observed aggregation, which proves its plasmon nature. The laser-induced transformations in the D–g–PNIPAM/AgNPs nanosystem have been found to be essentially irreversible that differs principally them from the temperature-induced transformations. Such fundamental difference proves the crucial role of the optical forces arising due to the excitation of surface plasmons in Ag NPs.

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Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin

Cited by 7 publications

References 39 publications

Experimental Approach to the Creation of Efficient Multicomponent Nanocomposites for Antitumor Therapy

Experimental Approach to the Creation of Efficient Multicomponent Nanocomposites for Antitumor Therapy

Evaluation of a Dextran-Poly(N-Isopropylacrylamide) Copolymer as a Potential Temperature-Dependent Nanocarrier for Photosensitizers with Different Properties

Laser-Driven Aggregation in Dextran–Graft–PNIPAM/Silver Nanoparticles Hybrid Nanosystem: Plasmonic Effects

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