Staphylococcus pseudintermedius, both commensal and pathogen

Chrobak-Chmiel, Dorota; Golke, Anna; Dembele, K.; Ćwiek, Karolina; Kizerwetter-Świda, Magdalena; Rzewuska, Magdalena; Binek, M.

doi:10.21521/mw.6042

Cited by 5 publications

(13 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adaptation to different hosts allows them to spread effectively (Gortazar et al 2014). Pathogens that until recently were considered to be typically animal, causing only diseases in animals or constituting their microbiota, can now also cause human infections, including life-threatening ones (Van Hoovels et al 2006;Chrobak-Chmiel et al 2018;Gonzalez-Martin et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Pathogenic potential and antimicrobial resistance of Staphylococcus pseudintermedius isolated from human and animals

2022

View full text Add to dashboard Cite

Crossing of interspecies barriers by microorganisms is observed. In recent years, Staphylococcus pseudintermedius—a species formerly thought to be animal—has also been isolated from human clinical materials. Many virulence factors are responsible for the colonization, which is the first step an infection, of the new host organism. We analyzed the factors influencing this colonization as well as susceptibility to antibiotics in fourteen S. pseudintermedius strains isolated from clinical cases from humans and animals. The occurrence of genes responsible for binding elastin, fibronectin, and fibrinogen and some phenotypic features, although different between strains, is comparable in both groups. However, the animal isolates had more genes coding for virulence factors. All isolates tested had the exfoliating toxin gene and the leukotoxin determining genes, but only the human strains had enterotoxin genes. The assessment of antibiotic resistance of strains of both groups indicates their broad resistance to antibiotics commonly used in veterinary medicine. Antibiotic resistance was more common among animal isolates. The multilocus sequence typing analysis of the studied strains was performed. The results indicated a large diversity of the S. pseudintermedius population in both studied groups of strains. Equipped with important virulence factors, they showed the ability to infect animals and humans. The clonal differentiation of the methicillin-susceptible strains and the multidrug resistance of the strains of both studied groups should be emphasized. The considerable genetic diversity of strains from a limited geographical area indicates the processes of change taking place within this species. Thus, careful observation of the ongoing process of variation is necessary, as they may lead to the selection of S. pseudintermedius, which will pose a significant threat to humans.

show abstract

Section: Introductionmentioning

confidence: 99%

Pathogenic potential and antimicrobial resistance of Staphylococcus pseudintermedius isolated from human and animals

2022

View full text Add to dashboard Cite

show abstract

“…schleiferi ( S. schleiferi ) has been implicated in a number of infections in humans and companion animals [12345]. Although coagulase-positive Staphylococcus pseudintermedius has most frequently been recognized as a causative pathogen for canine pyoderma and otitis [678], the pathogenic potential of S. schleiferi and other coagulase-negative staphylococci (CoNS) in dogs has been underestimated. Furthermore, the recent emergence of S. schleiferi among clinically healthy dogs and dogs with otitis externa and/or pyoderma has become a significant global issues in veterinary medicine due its high antimicrobial resistance and variety of virulence factors [239].…”

Section: Introductionmentioning

confidence: 99%

Carriage ofStaphylococcus schleiferifrom canine otitis externa: antimicrobial resistance profiles and virulence factors associated with skin infection

Lee

Hwang

et al. 2019

J Vet Sci

View full text Add to dashboard Cite

The recent emergence of Staphylococcus schleiferi in dogs with otitis externa or skin and soft tissue infections has become a significant zoonotic issues. In the current study, we investigated 1) the carriage rates of S. schleiferi among major staphylococci in healthy dogs and dogs with otitis externa, 2) antibiotic susceptibility profiles of S. schleiferi, particularly methicillin resistance (MR), and 3) virulence factors associated with skin and soft tissue infections such as ability to form biofilm, resistance to cationic antimicrobial peptides (CAMPs), and carriage of staphylococcal enterotoxin genes. Among the 21 S. schleiferi isolates, 5 isolates (24%) were determined to be methicillin-resistant (MRSS). Staphylococcal cassette chromosome mec (SCC mec ) typing revealed the presence of SCC mec type V in 4 MRSS isolates and type VII in one MRSS. Higher levels of antibiotic resistance, especially multidrug resistance, were observed in MRSS isolates compared to the methicillin-susceptible S. schleiferi (MSSS) isolates. In addition, MRSS isolates exhibited enhanced ability to form biofilm under static condition and all the 5 MRSS isolates carried three or more enterotoxin genes. However, there were no significant differences in resistance to CAMPs between MRSS and MSSS isolates. These findings suggest that coagulase-negative S. schleiferi is becoming more prevalent in canine otitis externa cases. Our results also highlight the presence of multidrug-resistant MRSS isolates with enhanced biofilm production and carriage of multiple enterotoxins.

show abstract

“…In dogs with atopic dermatitis (AD), a superficial pyoderma associated with Staphylococcus pseudintermedius is very commonly observed. 1 In general, antimicrobial drugs and topical therapies are used routinely to control the pyoderma. However, since the emergence of multidrug-resistant (MDR) and meticillin/oxacillin resistant (MR) S. pseudintermedius (MRSP) worldwide, current treatment options reveal limitations in the choice of antimicrobial drugs.…”

Section: Introductionmentioning

confidence: 99%

“…In dogs with atopic dermatitis (AD), a superficial pyoderma associated with Staphylococcus pseudintermedius is very commonly observed 1 . In general, antimicrobial drugs and topical therapies are used routinely to control the pyoderma.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial

Hsiao¹,

Imanishi

Iyori³

2021

Veterinary Dermatology

View full text Add to dashboard Cite

Background Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. Objective The antimicrobial effect of olanexidine was evaluated using minimal inhibitory concentration (MIC) towards Staphylococcus pseudintermedius. Furthermore, its clinical efficacy in canine superficial pyoderma was assessed in a randomized, single‐blinded study. Animals Twenty‐eight client‐owned dogs with atopic dermatitis and superficial pyoderma. Methods and materials The MIC of olanexidine was determined for S. pseudintermedius isolates (n=73) by serial dilution of 96‐well broth microdilution method. Regarding the clinical trial, all recruited dogs were randomized into two groups; one treated with 1.5% olanexidine spray once daily and the other with a 3% chlorhexidine shampoo once a week for 2 times, respectively. Clinical assessment was performed at days 0 and 14 according to the guidelines of the Japanese Society of Antimicrobials for Animals. Results The MIC values for methicillin‐resistant S. pseudintermedius (MRSP) and methicillin‐sensitive S. pseudintermedius (MSSP) were 0.23 μg/ml and 0.24 μg/ml (P =0.9), respectively. In clinical trial, olanexidine and chlorhexidine showed substantial improvement in clinical presentation compared to the baseline. Conclusions and clinical importance Olanexidine showed comparable efficacy to chlorhexidine (P=0.73). Moreover, the MIC against S. pseudintermedius indicated high bactericidal activity, which was supported by the topical effectiveness of olanexidine.

show abstract

Staphylococcus pseudintermedius, both commensal and pathogen

Cited by 5 publications

References 112 publications

Pathogenic potential and antimicrobial resistance of Staphylococcus pseudintermedius isolated from human and animals

Pathogenic potential and antimicrobial resistance of Staphylococcus pseudintermedius isolated from human and animals

Carriage ofStaphylococcus schleiferifrom canine otitis externa: antimicrobial resistance profiles and virulence factors associated with skin infection

Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial

Contact Info

Product

Resources

About