Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

Decalonne, Marie; Santos, Sandra Dos; Gimenes, Rémi; Goube, Florent; Abadie, Géraldine; Aberrane, Saïd; Ambrogi, Vanina; Baron, R.; Barthelemy, Patrick; Bauvin, I.; Belmonte, Olivier; Benabid, Emilie; Ammar, Rafik Ben; Yahia, Salma Ben Hadj; Berrouane, Yasmina; Berthelot, Philippe; Beuchée, Alain; Bille, Emmanuelle; Bolot, Pascal; Bordes-Couecou, S.; Bouissou, Antoine; Bourdon, Sandra; Bourgeois-Nicolaos, Nadège; Boyer, Sophie; Cattöen, C.; Cattoir, Vincent; Chaplain, C.; Chatelet, Céline; Claudinon, Aurore; Chautemps, Nathalie; Cormier, H.; Coroller-Bec, Céline; Cotté, Benjamin; Chillaz, Carole De; Dauwalder, Olivier; Davy, Aude; Delorme, Martine; Demasure, M.; Desfrère, Luc; Drancourt, Michel; Dupin, Clarisse; Faraut-Derouin, Véronique; Florentin, Arnaud; Forget, Virginie; Fortineau, Nicolas; Foucan, Tania; Frange, Pierre; Gambarotto, Karine; Gascoin, Géraldine; Gibert, Laure; Gilquin, Jacques; Glanard, Audrey; Grando, J.; Gravet, Alain; Guinard, Jérôme; Héry-Arnaud, Geneviève; Huart, C.; Idri, N.; Jellimann, Jean-Marc; Join‐Lambert, Olivier; Joron, S.; Jouvencel, P.; Kempf, Marie; Ketterer-Martinon, S.; Khecharem, Mouna; Klosowski, S; Labbé, F.; Lacazette, Adeline; Lapeyre, Fabrice; Larché, Jérôme; Larroude, Peggy; Pourhiennec, Anne Le; Saché, Nolwenn Le; Ledru, Sylvie; Lefebvre, A.; Legeay, Clément; Lémann, F.; Lesteven, Claire; Levast-Raffin, Marion; Leyssene, D.; Ligi, Isabelle; Lozniewski, Alain; Lureau, Pierre; Mallaval, Franck-Olivier; Malpote, Edith; Marret, Stéphane; Martres, Pascale; Ménard, Guillaume; Menvielle, Laura; Mereghetti, Laurent; Merle, V.; Minery, Pascale; Morange, Virginie; Mourdie, Julien; Muggeo, Anaëlle; Nakhleh, Jean; Noulard, Marie-Noëlle; Olive, Claude; Patural, Hugues; Penn, Pascale; Petitfrere, Manuel; Pozetto, Bruno; Rivière, Brigitte; Robine, Audrey; Roques, Christine; Ruimy, Raymond; Siali, A.; Soive, Stéphanie; Slimani, Souad; Trentesaux, Anne-Sophie; Trivier, Dominique; Vandenbussche, C.; Villeneuve, Laurent; Werner, Evelyne; Vu, Stéphane Le; Mee-Marquet, Nathalie van der

doi:10.1007/s10096-020-03925-5

Cited by 15 publications

(11 citation statements)

References 13 publications

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“…Previous reports demonstrated that S. epidermidis and S. capitis were detected in the GI tract and from aerosols after dental procedures 19–21 . S. capitis , mostly detected in CS, is a sepsis causative microorganism that occurs due to bacterial translocation from the intestine, 22 causing severe infections, especially in children susceptible to infection. Furthermore, 16S rRNA gene sequencing in DE without WCP identified Micrococcus sp.…”

Section: Discussionmentioning

confidence: 99%

Bacterial exposure risk to the endoscopist's face while performing endoscopy

et al. 2023

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Objectives Gastrointestinal endoscopy increases the risk of bacterial exposure to endoscopists. However, before 2019, most endoscopists did not pay attention to microorganism transmission from patients. This study aimed to investigate the incidence of bacterial exposure to endoscopists’ faces during gastrointestinal endoscopic procedures using the bacterial culture method. Methods This was a single‐centered, retrospective study including endoscopists who performed various gastrointestinal endoscopy procedures at the Division of Endoscopy, Hirosaki University Hospital between August 31 and October 6, 2020. Endoscopists wore surgical masks and affixed pre‐sterilized films over them. Following the gastrointestinal endoscopic procedures, attached microbes were collected from the endoscopists’ surface films using sterilized swabs. Collected microorganisms were cultured on tryptic soy agar and 5% sheep blood agar, and the incidence of bacterial exposure was determined by bacterial culture positivity. Cultured bacteria were identified by gram staining and 16S rRNA gene sequencing. Results Bacterial culture positivity was 12.6%, and it was significantly higher in therapeutic than in diagnostic endoscopy. Notably, therapeutic endoscopy increased bacterial culture positivity in colonoscopy, but not in esophagogastroduodenoscopy. Staphylococci, including Staphylococcus epidermidis and Staphylococcus capitis, were the most commonly found bacteria in samples identified through 16S rRNA gene sequencing. Conclusions The risk of bacterial exposure to the endoscopist's face was increased in colonoscopy treatment procedures. Therefore, endoscopists should be aware of the significant risk of microbial infection from scattering fluid that comes from the endoscopy's working channel.

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Section: Discussionmentioning

confidence: 99%

Bacterial exposure risk to the endoscopist's face while performing endoscopy

et al. 2023

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“…The most common presentation for S. capitis infection in neonates was bacteraemia, with or without the presence of a central venous catheter (CVC) [ 81 ]. In one CoNS bacteraemia study, 50% of cases were catheter-related, and 67.1% of these were linked to CVCs, while other sources included the digestive tract (12.1%) and skin (8.5%) [ 82 ]. In a 2020 study by Adeghate et al [ 83 ], it was noted that gastrointestinal tract colonisation with CoNS was associated with an increased incidence of bacteraemia, with both CoNS and Enterobacterales species [ 83 ].…”

Section: Staphylococcus Capitis Infection and Colonisation I...mentioning

confidence: 99%

“…However, no adult outbreaks have been reported in the peer-reviewed literature [ 91 ]. Most centres in France still routinely use vancomycin to treat bacteraemia, even in the presence of an NRCS-A clone outbreak, as the isolates are phenotypically sensitive to vancomycin, although they are resistant to gentamicin and methicillin [ 82 ].…”

Section: Neonatal Outbreaksmentioning

confidence: 99%

Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

et al. 2023

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In June 2021, a national incident team was formed due to an increased detection of Staphylococcus capitis in samples from hospitalised infants. Staphylococcus capitis has been known to cause outbreaks in neonatal units across the globe, but the extent of the UK spread was unclear. A literature review was undertaken to support case identification, clinical management and environmental infection control. A literature search was undertaken on multiple databases from inception to 24 May 2021, using keywords such as “Staphylococcus capitis”, “NRCS-A”, “S. capitis”, “neonate”, “newborn” and “neonatal intensive care unit” (NICU). After screening, 223 articles of relevance were included. Results show incidences of S. capitis outbreaks have frequently been associated with the outbreak clone (NRCS-A) and environmental sources. The NRCS-A harbours a multidrug resistance profile that includes resistance to beta-lactam antibiotics and aminoglycosides, with several papers noting resistance or heteroresistance to vancomycin. The NRCS-A clone also harbours a novel SCCmec-SCCcad/ars/cop composite island and increased vancomycin resistance. The S. capitis NRCS-A clone has been detected for decades, but the reasons for the potentially increased frequency are unclear, as are the most effective interventions to manage outbreaks associated with this clone. This supports the need for improvements in environmental control and decontamination strategies to prevent transmission.

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“…Recently, isolates have emerged that are also resistant to vancomycin [21]. The NRCS-A clone of S. capitis has emerged as a pathogen within NICUs worldwide, and many isolates show some degree of vancomycin resistance [22,23]. Identification of methicillinresistant S. aureus strains that are also vancomycinintermediate or vancomycin-resistant is similarly concerning.…”

Section: Gram-positivementioning

confidence: 99%

Neonatal bloodstream infections

Hadfield¹,

Cantey²

2021

Current Opinion in Infectious Diseases

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Purpose of review Neonatal bloodstream infections (BSI) are a major contributor to morbidity and mortality within neonatal intensive care units. BSI, including central line-associated BSI, have decreased over the past 15 years but remain common in extremely preterm infants. The purpose of this review is to highlight recent advances in the causes, diagnosis, management, and prevention of neonatal BSI. Recent findings Continued quality improvement efforts and bundles have reduced BSI incidence, and novel approaches are highlighted. An update of emerging pathogens as well as traditional pathogens with novel antimicrobial resistance, which are an increasingly common cause of neonatal BSI, is included. Finally, current and future investigations into serum or noninvasive biomarkers for neonatal BSI are reviewed. Summary Neonatal BSIs continue to decrease due to enhanced infection control and prevention techniques. However, many challenges remain, including emerging bacterial and fungal resistance and the continued need for novel diagnostics that hasten time to pathogen identification and effective treatment. This review of the past 18 months highlights the rapid changes in this area. Ongoing efforts to reduce the morbidity and mortality caused by neonatal BSI must remain a priority.

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Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

Cited by 15 publications

References 13 publications

Bacterial exposure risk to the endoscopist's face while performing endoscopy

Bacterial exposure risk to the endoscopist's face while performing endoscopy

Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

Neonatal bloodstream infections

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